KEGG   PATHWAY: rn00965
Entry
rn00965                     Pathway                                
Name
Betalain biosynthesis
Description
Betalains are water-soluble nitrogen-containing pigments that are present in plants belonging to the order Caryophyllales (such as cactus and amaranth families) and in higher fungi. They contain betalamic acid as the chromophore and are classified into two types: betacyanins and betaxanthins. Betacyanins contain a cyclo-DOPA residue and exhibit red/violet coloration, while betaxanthins contain different amino acids or amino side chains and exhibit a yellow/orange coloration. The condensation of betalamic acid with amino acids (including cyclo-DOPA or amines) in plants is a spontaneous reaction, not an enzyme-catalyzed reaction.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00965  Betalain biosynthesis
rn00965

Module
M00961  Betacyanin biosynthesis, L-tyrosine => amaranthin [PATH:rn00965]
Reaction
R02080  3,4-dihydroxy-L-phenylalanine carboxy-lyase
R04301  S-adenosyl-L-methionine:catechol O-methyltransferase
R08816  UDP-glucose:2,3-dihydro-5,6-dihydroxyindole-2-carboxylate 5-O-beta-D-glucosyltransferase
R08817  UDP-glucuronate:cyclo-DOPA-5-O-glucoside 2'-O-beta-D-glucuronosyltransferase
R08818   
R08819  1-O-feruloyl-beta-D-glucose:amaranthin feruloyltransferase
R08820   
R08821   
R08822  UDP-glucose:betanidin 5-O-beta-D-glucosyltransferase
R08823  1-O-feruloyl-beta-D-glucose:betanin feruloyltransferase
R08824  UDP-glucuronate:betanin beta-D-glucuronosyltransferase
R08825   
R08826  portulacaxanthin-II,dopaxanthin:oxygen oxidoreductase
R08827   
R08828  dopaxanthin:oxygen oxidoreductase
R08829   
R08830  UDP-glucose:betanidin 6-O-beta-D-glucosyltransferase
R08831   
R08832  dopamine:oxygen oxidoreductase
R08833   
R08834   
R08835   
R08836  3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (decyclizing)
R08837   
R13031   
R13032   
Compound
C00082  L-Tyrosine
C00355  3,4-Dihydroxy-L-phenylalanine
C03758  Dopamine
C05587  3-Methoxytyramine
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C08537  Amaranthin
C08538  Betalamic acid
C08539  Betanidin
C08540  Betanin
C08542  Celosianin II
C08543  Dopaxanthin
C08544  Gomphrenin-I
C08552  Lampranthin II
C08557  Miraxanthin-V
C08565  Portulacaxanthin II
C17751  cyclo-Dopa 5-O-glucoside
C17752  cyclo-Dopa-glucuronylglucoside
C17753  Dopaxanthin quinone
C17754  3-Methoxytyramine-betaxanthin
C17755  Dopamine quinone
C17756  2-Descarboxy-cyclo-dopa
C17757  2-Descarboxy-betanidin
C17758  4,5-seco-Dopa
Reference
  Authors
Gandia-Herrero F, Escribano J, Garcia-Carmona F
  Title
Betaxanthins as substrates for tyrosinase. An approach to the role of tyrosinase in the biosynthetic pathway of betalains.
  Journal
Plant Physiol 138:421-32 (2005)
DOI:10.1104/pp.104.057992
Reference
  Authors
Sasaki N, Abe Y, Wada K, Koda T, Goda Y, Adachi T, Ozeki Y
  Title
Amaranthin in feather cockscombs is synthesized via glucuronylation at the cyclo-DOPA glucoside step in the betacyanin biosynthetic pathway.
  Journal
J Plant Res 118:439-42 (2005)
DOI:10.1007/s10265-005-0237-z
Reference
  Authors
Strack D, Vogt T, Schliemann W
  Title
Recent advances in betalain research.
  Journal
Phytochemistry 62:247-69 (2003)
DOI:10.1016/S0031-9422(02)00564-2
Reference
  Authors
Vogt T
  Title
Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis.
  Journal
Planta 214:492-5 (2002)
DOI:10.1007/s00425-001-0685-1
Related
pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko00965   
LinkDB

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