KEGG   PATHWAY: rno03320
Entry
rno03320                    Pathway                                
Name
PPAR signaling pathway - Rattus norvegicus (rat)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
rno03320  PPAR signaling pathway
rno03320

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29184  Cd36; platelet glycoprotein 4 [KO:K06259]
499985  Cd36l1; CD36 molecule like 1 [KO:K06259]
120093085  Cd36-ps1; platelet glycoprotein 4-like [KO:K06259]
134486712  platelet glycoprotein 4-like [KO:K06259]
94172  Slc27a1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
311839  Slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
65192  Slc27a2; long-chain fatty acid transport protein 2 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
79111  Slc27a5; long-chain fatty acid transport protein 5 [KO:K08748] [EC:6.2.1.7]
291582  Slc27a6; long-chain fatty acid transport protein 6 [KO:K08749]
24360  Fabp1; fatty acid-binding protein, liver [KO:K08750]
25598  Fabp2; fatty acid-binding protein, intestinal [KO:K08751]
79131  Fabp3; fatty acid-binding protein, heart [KO:K08752]
79451  Fabp4; fatty acid-binding protein, adipocyte [KO:K08753]
140868  Fabp5; fatty acid-binding protein 5 [KO:K08754]
108348948  fatty acid-binding protein 5-like [KO:K08754]
25440  Fabp6; gastrotropin [KO:K08755]
80841  Fabp7; fatty acid-binding protein, brain [KO:K08756]
25747  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
25271  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
361801  Rxrb; retinoic acid receptor RXR-beta [KO:K08525]
83574  Rxrg; retinoic acid receptor RXR-gamma [KO:K08526]
25682  Ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
25664  Pparg; peroxisome proliferator-activated receptor gamma isoform 1 [KO:K08530]
29637  Hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
24450  Hmgcs2; hydroxymethylglutaryl-CoA synthase, mitochondrial precursor [KO:K01641] [EC:2.3.3.10]
25081  Apoa1; apolipoprotein A-I preproprotein [KO:K08757]
25649  Apoa2; apolipoprotein A-II preproprotein [KO:K08758]
24207  Apoc3; apolipoprotein C-III precursor [KO:K08759]
140638  Apoa5; apolipoprotein A-V precursor [KO:K09025]
296371  Pltp; phospholipid transfer protein precursor [KO:K08761]
24552  Me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
361602  Me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
83512  Fads2; acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
83792  Scd2; stearoyl-CoA desaturase 2 [KO:K00507] [EC:1.14.19.1]
246074  Scd; acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
499358  Scd4; stearoyl-CoA desaturase 4 [KO:K00507] [EC:1.14.19.1]
681458  Scd3; acyl-CoA desaturase 3 [KO:K00507] [EC:1.14.19.1]
25428  Cyp7a1; cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
81924  Cyp8b1; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor [KO:K07431] [EC:1.14.14.139]
58852  Nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
301517  Cyp27a1; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
25045  Dbi; acyl-CoA-binding protein [KO:K08762]
59116  Dbil5; diazepam-binding inhibitor-like 5 [KO:K08762]
102553848  acyl-CoA-binding protein-like [KO:K08762]
24539  Lpl; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
94340  Acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
113976  Acsl4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
114024  Acsl3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
117243  Acsl6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
25288  Acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
171410  Acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
301120  Acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
316124  Acsbg3; uncharacterized protein LOC316124 [KO:K15013] [EC:6.2.1.3]
140914  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
171142  Ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
298423  Cyp4a3; cytochrome P450 4A14 [KO:K07425] [EC:1.14.14.80]
50549  Cyp4a1; cytochrome P450 4A10 [KO:K07425] [EC:1.14.14.80]
266674  Cyp4a8; cytochrome P450 4A12 [KO:K07425] [EC:1.14.14.80]
120102953  Cyp4a2l1; cytochrome P450, family 4, subfamily a, polypeptide 2 like 1 [KO:K07425] [EC:1.14.14.80]
24306  Cyp4a2; cytochrome P450 4A2 [KO:K07425] [EC:1.14.14.80]
24157  Acaa1a; 3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 [KO:K07513] [EC:2.3.1.16]
501072  Acaa1b; 3-ketoacyl-CoA thiolase B, peroxisomal precursor [KO:K07513] [EC:2.3.1.16]
25541  Scp2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
83522  Acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
50681  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform 2 [KO:K00232] [EC:1.3.3.6]
252898  Acox2; peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:1.17.99.3]
25757  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
25756  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
308579  Cpt1c; palmitoyl thioesterase CPT1C [KO:K19524] [EC:2.3.1.21]
25413  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial precursor [KO:K08766] [EC:2.3.1.21]
25287  Acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00255] [EC:1.3.8.8]
24158  Acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00249] [EC:1.3.8.7]
362850  Angptl4; angiopoietin-related protein 4 precursor [KO:K08767]
686098  Sorbs1; sorbin and SH3 domain-containing protein 1 [KO:K06086]
25629  Plin1; perilipin-1 [KO:K08768]
298199  Plin2; perilipin-2 isoform 1 [KO:K17284]
363331  Plin4; perilipin-4 isoform X1 [KO:K20254]
501283  Plin5; perilipin-5 [KO:K20255]
246253  Adipoq; adiponectin precursor [KO:K07296]
300339  Mmp1; interstitial collagenase precursor [KO:K01388] [EC:3.4.24.7]
300338  Mmp1b; interstitial collagenase B [KO:K01388] [EC:3.4.24.7]
24860  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
170922  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
81745  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
50522  Ubc; polyubiquitin-C isoform 3 precursor [KO:K08770]
362282  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
361042  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
79223  Gk; glycerol kinase [KO:K00864] [EC:2.7.1.30]
289481  Gk2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
291468  Gykl1; glycerol kinase-like 1 [KO:K00864] [EC:2.7.1.30]
29171  Aqp7; aquaporin-7 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
rno00071  Fatty acid degradation
rno00120  Primary bile acid biosynthesis
rno00564  Glycerophospholipid metabolism
rno04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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