KEGG   PATHWAY: rtem00564
Entry
rtem00564                   Pathway                                
Name
Glycerophospholipid metabolism - Rana temporaria (common frog)
Class
Metabolism; Lipid metabolism
Pathway map
rtem00564  Glycerophospholipid metabolism
rtem00564

Module
rtem_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:rtem00564]
rtem_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:rtem00564]
rtem_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:rtem00564]
Other DBs
GO: 0006650
Organism
Rana temporaria (common frog) [GN:rtem]
Gene
120929080  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
120940311  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
120944295  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
120944098  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
120910380  GPAM; LOW QUALITY PROTEIN: glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
120932999  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
120933157  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
120915721  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
120913233  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
120913832  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
120937408  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120926772  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120936971  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
120935804  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
120940755  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120927350  lysophospholipid acyltransferase 2-like [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120936364  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120937594  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
120937647  dihydroxyacetone phosphate acyltransferase-like isoform X1 [KO:K00649] [EC:2.3.1.42]
120918990  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120919145  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120928354  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
120946103  PLPP3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
120910049  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
120933440  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120918761  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
120940897  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
120936325  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
120947031  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120933176  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120918859  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
120929524  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
120947019  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
120929649  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
120939856  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
120932881  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
120917125  diacylglycerol kinase zeta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
120936502  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
120932135  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
120927217  choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
120933608  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
120936751  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
120913291  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
120917740  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
120937270  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120947188  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120915389  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
120943522  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120916869  basic phospholipase A2 taipoxin alpha chain-like [KO:K01047] [EC:3.1.1.4]
120927691  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
120917655  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120917693  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120946099  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120920799  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
120920948  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
120921142  cytosolic phospholipase A2 delta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120924718  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120924719  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120924720  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120945539  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120945396  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
120935801  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
120917343  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120917619  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120917620  uncharacterized protein LOC120917620 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120940581  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120917451  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120940563  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
120922640  lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
120922804  lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
120940994  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
120917468  PLA2G15; LOW QUALITY PROTEIN: phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
120928277  acyl-protein thioesterase 2-like [KO:K06130] [EC:3.1.1.5]
120926786  acyl-protein thioesterase 2-like [KO:K06130] [EC:3.1.1.5]
120914064  PNPLA7; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
120933208  patatin-like phospholipase domain-containing protein 6 [KO:K14676] [EC:3.1.1.5]
120938026  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
120909089  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
120933450  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
120931571  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120917546  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120919557  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
120927495  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
120936877  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
120941278  ethanolaminephosphotransferase 1-like [KO:K00993] [EC:2.7.8.1]
120936208  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
120932761  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
120918919  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
120917521  phosphomethylethanolamine N-methyltransferase-like isoform X1 [KO:K05929] [EC:2.1.1.103]
120917861  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
120943187  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
120932989  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
120915731  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
120928107  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
120941403  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
120917227  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
120936933  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
120922168  phosphatidylserine decarboxylase proenzyme, mitochondrial-like isoform X1 [KO:K01613] [EC:4.1.1.65]
120919065  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
120938033  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
120913935  tafazzin [KO:K13511] [EC:2.3.1.-]
120937925  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
120943059  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
120916555  MBOAT7; LOW QUALITY PROTEIN: lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
rtem00010  Glycolysis / Gluconeogenesis
rtem00260  Glycine, serine and threonine metabolism
rtem00561  Glycerolipid metabolism
rtem00562  Inositol phosphate metabolism
rtem00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
rtem00565  Ether lipid metabolism
rtem00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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