KEGG   PATHWAY: scac04150
Entry
scac04150                   Pathway                                
Name
mTOR signaling pathway - Stomoxys calcitrans (stable fly)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
scac04150  mTOR signaling pathway
scac04150

Organism
Stomoxys calcitrans (stable fly) [GN:scac]
Gene
106083702  large neutral amino acids transporter small subunit 1 [KO:K13780]
106094761  Y+L amino acid transporter 2 [KO:K13780]
106087941  Y+L amino acid transporter 2 [KO:K13780]
106080640  maltase 2 isoform X1 [KO:K06519]
106091039  V-type proton ATPase catalytic subunit A isoform 2-like [KO:K02145] [EC:7.1.2.2]
106083604  V-type proton ATPase catalytic subunit A isoform 1 [KO:K02145] [EC:7.1.2.2]
106080686  V-type proton ATPase catalytic subunit A isoform 2 [KO:K02145] [EC:7.1.2.2]
106082125  V-type proton ATPase subunit B [KO:K02147]
106085191  V-type proton ATPase subunit C [KO:K02148]
106087432  V-type proton ATPase subunit D 1 [KO:K02149]
106089131  V-type proton ATPase subunit D-like [KO:K02149]
106093790  V-type proton ATPase subunit E [KO:K02150]
106082731  V-type proton ATPase subunit F 1 [KO:K02151]
106082883  V-type proton ATPase subunit F-like [KO:K02151]
106087216  V-type proton ATPase subunit G [KO:K02152]
106092989  V-type proton ATPase subunit H [KO:K02144]
106093436  uncharacterized protein LOC106093436 [KO:K20397]
106092808  ragulator complex protein LAMTOR2 homolog [KO:K20398]
106083073  ragulator complex protein LAMTOR3 homolog [KO:K04370]
106090947  ragulator complex protein LAMTOR4 homolog [KO:K20399]
106085102  uncharacterized protein LOC106085102 [KO:K16344]
106092552  folliculin [KO:K09594]
106084446  uncharacterized protein LOC106084446 isoform X1 [KO:K20401]
106090678  ras-related GTP-binding protein A [KO:K16185]
106085307  ras-related GTP-binding protein C [KO:K16186]
106093174  WD repeat-containing protein mio [KO:K20407]
106087089  nucleoporin seh1 [KO:K14299]
106096252  WD repeat-containing protein 24 [KO:K20408]
106095586  WD repeat-containing protein 59 homolog [KO:K20409]
106089792  protein SEC13 homolog [KO:K14004]
106089411  DEP domain-containing protein 5 [KO:K20404]
106095981  nitrogen permease regulator 2-like protein [KO:K20405]
106094431  nitrogen permease regulator 3-like protein [KO:K20406]
106080639  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
106085549  regulatory-associated protein of mTOR-like isoform X1 [KO:K07204]
106089840  target of rapamycin [KO:K07203] [EC:2.7.11.1]
106093276  protein LST8 homolog [KO:K08266]
106085574  TELO2-interacting protein 1 homolog [KO:K20403]
106095569  restin homolog isoform X1 [KO:K10421]
106085316  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
106090097  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
106090081  eukaryotic translation initiation factor 4E-like [KO:K03259]
106090153  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
106093107  eukaryotic translation initiation factor 4B-like [KO:K03258]
106086297  40S ribosomal protein S6 [KO:K02991]
106091816  putative serine/threonine-protein kinase STE20-like [KO:K08271]
106083341  serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
106085253  protein Mo25 [KO:K08272]
106093713  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
106090227  hamartin [KO:K07206]
106093055  tuberin [KO:K07207]
106080544  TBC1 domain family member 7 [KO:K20396]
106091130  GTP-binding protein Rheb homolog [KO:K07208]
106082574  protein wingless [KO:K03209]
106091921  homeotic protein female sterile-like [KO:K00444]
106089088  protein Wnt-5 [KO:K00444]
106087683  protein Wnt-6 [KO:K00445]
106083920  wnt inhibitor of Dorsal protein-like [KO:K00714]
106083930  wnt inhibitor of Dorsal protein-like [KO:K00714]
106087586  protein Wnt-10b [KO:K01357]
106093022  frizzled [KO:K02432]
106089530  frizzled-like [KO:K02432]
106086391  frizzled-4 [KO:K02354]
106094496  frizzled-2 [KO:K02375]
106085728  frizzled-3 [KO:K04690]
106088369  low-density lipoprotein receptor-related protein 6 [KO:K03068]
106086394  segment polarity protein dishevelled [KO:K02353]
106082908  serine/threonine-protein kinase PKH2 isoform X1 [KO:K03083] [EC:2.7.11.26]
106088471  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106094793  probable insulin-like peptide 3 [KO:K04526]
106094794  probable insulin-like peptide 1 [KO:K04526]
106094866  probable insulin-like peptide 3 [KO:K04526]
106094921  probable insulin-like peptide 3 [KO:K04526]
106095269  probable insulin-like peptide 5 [KO:K04526]
106086464  LIRP-like [KO:K04526]
106088789  probable insulin-like peptide 3 [KO:K04526]
106084784  insulin-like receptor [KO:K05087] [EC:2.7.10.1]
106088371  protein enhancer of sevenless 2B [KO:K04364]
106080767  protein son of sevenless [KO:K03099]
106088091  ras-like protein 1 [KO:K07827]
106083012  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
106083022  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106081155  mitogen-activated protein kinase ERK-A [KO:K04371] [EC:2.7.11.24]
106090291  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
106081749  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106080751  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106094275  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
106081609  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106089814  stress-activated map kinase-interacting protein 1 [KO:K20410]
106088531  uncharacterized protein LOC106088531 isoform X1 [KO:K08267]
106094239  rho-related GTP-binding protein RhoC-like [KO:K04513]
106087470  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
106096281  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
106096305  protein kinase C, eye isozyme [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
scac00561  Glycerolipid metabolism
scac04140  Autophagy - animal
KO pathway
ko04150   
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