KEGG   PATHWAY: vko00564
Entry
vko00564                    Pathway                                
Name
Glycerophospholipid metabolism - Varanus komodoensis (Komodo dragon)
Class
Metabolism; Lipid metabolism
Pathway map
vko00564  Glycerophospholipid metabolism
vko00564

Module
vko_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:vko00564]
vko_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:vko00564]
vko_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:vko00564]
Other DBs
GO: 0006650
Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123027512  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
123016798  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
123019259  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
123016958  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
123027642  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
123016763  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
123027092  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
123022700  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
123034396  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
123031741  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
123017805  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
123035166  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
123019088  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
123029462  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
123019311  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
123027202  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
123021579  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
123017222  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
123018591  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
123035487  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
123035389  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
123031377  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
123023417  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
123030044  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
123016998  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
123028454  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
123020334  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
123033745  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
123027082  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
123032370  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
123033143  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
123034969  diacylglycerol kinase delta-like [KO:K00901] [EC:2.7.1.107]
123022766  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
123028863  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
123019282  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
123025633  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
123026099  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
123030270  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
123026910  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
123028828  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
123031961  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
123016633  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
123025600  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123032527  5'-3' exonuclease PLD3-like isoform X1 [KO:K16860] [EC:3.1.4.4]
123026356  PLD4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
123021046  PLD3; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
123025363  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
123032793  acidic phospholipase A2 HTe-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123034721  basic phospholipase A2 sphenotoxin subunit B-like [KO:K01047] [EC:3.1.1.4]
123034725  basic phospholipase A2 Cdr-13-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123034728  basic phospholipase A2 Ceg-N6-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123023193  PLA2G12A; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123018447  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
123025134  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123025419  phospholipase A2, minor isoenzyme-like isoform X1 [KO:K01047] [EC:3.1.1.4]
123030419  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123030949  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
123027870  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123026284  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026285  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026286  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026289  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026290  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123026292  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026293  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
123026366  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
123030607  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
123030608  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
123026805  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
123026807  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123026808  cytosolic phospholipase A2 delta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
123028039  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
123032561  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032562  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032563  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123032564  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123022375  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
123029683  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
123019466  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
123033178  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
123020283  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
123025402  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
123020662  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
123035139  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
123019426  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
123030312  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
123018257  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
123016704  ACHE; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
123021267  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
123023156  CHKB; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
123030558  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
123036805  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
123029511  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
123018762  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
123033079  ethanolamine kinase 1-like [KO:K00894] [EC:2.7.1.82]
123034649  ETNK1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
123031029  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
123018115  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
123032548  phosphoethanolamine N-methyltransferase 3-like [KO:K05929] [EC:2.1.1.103]
123022807  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
123025198  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
123016786  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
123023171  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
123020502  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
123021151  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
123030455  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
123018097  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
123030315  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
123030130  TAFAZZIN; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
123032300  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
123032213  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
vko00010  Glycolysis / Gluconeogenesis
vko00260  Glycine, serine and threonine metabolism
vko00561  Glycerolipid metabolism
vko00562  Inositol phosphate metabolism
vko00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
vko00565  Ether lipid metabolism
vko00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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