KEGG ORTHOLOGY: K00458

ORTHOLOGY: K00458

Entry

K00458                      KO

Symbol

ALOX12

Name

arachidonate 12-lipoxygenase [EC:1.13.11.31]

Pathway

map00590

Arachidonic acid metabolism

map01100

Metabolic pathways

map01523

Antifolate resistance

map04726

Serotonergic synapse

map04750

Inflammatory mediator regulation of TRP channels

Reaction

R01596

arachidonate:oxygen 12-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00458  ALOX12; arachidonate 12-lipoxygenase
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00458  ALOX12; arachidonate 12-lipoxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00458  ALOX12; arachidonate 12-lipoxygenase
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K00458  ALOX12; arachidonate 12-lipoxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.31  arachidonate 12-lipoxygenase
     K00458  ALOX12; arachidonate 12-lipoxygenase

Other DBs

GO:

0004052

Genes

HSA:	239(ALOX12)

PTR:	455242(ALOX12) 455243

PPS:	100992721(ALOX12)

GGO:	101140132(ALOX12)

PON:	100435170 100448016

NLE:	100605486(ALOX12)

HMH:	116458265(ALOX12)

MCC:	713748(ALOX12)

MCF:	102136652(ALOX12)

MTHB:

126939829

MNI:

105473015

CSAB:

103242265(ALOX12)

CATY:

105582822(ALOX12)

PANU:

101012932(ALOX12)

TGE:	112609056(ALOX12)

MLEU:

105549914(ALOX12)

RRO:	104673348(ALOX12)

RBB:	108514395(ALOX12)

TFN:	117067814(ALOX12)

PTEH:

111521261(ALOX12)

CANG:

105523575(ALOX12)

CJC:	100400641(ALOX12)

SBQ:	101051396(ALOX12)

CIMI:

108306615(ALOX12)

CSYR:

103263245(ALOX12) 103263247

MMUR:

105878109(ALOX12) 105879294

LCAT:

123650840(ALOX12)

PCOQ:

105819472(ALOX12)

OGA:	100951876(ALOX12) 100961111

MMU:	11684(Alox12) 11685(Alox12e)

MCAL:

110304778(Alox12)

MPAH:

110331792(Alox12)

RNO:	287454(Alox12) 303252(Alox12e)

MCOC:

116077965

ANU:	117701406 117710866(Alox12) 117711132

MUN:

110540751

CGE:	100764620(Alox12)

MAUA:

101839190 101844629

PROB:

127219012 127219013(Alox12)

PLEU:

114693220(Alox12)

MORG:

121456507 121456764

MFOT:

126513995 126514127

AAMP:

119812811 119813474

NGI:	103752172(Alox12)

HGL:	101702123(Alox12)

CPOC:

100719400

CCAN:

109682903(Alox12)

DORD:

105983295 105983533(Alox12)

DSP:	122100378(Alox12)

PLOP:

125365503(Alox12)

NCAR:

124979056 124980537

MMMA:

107158101(Alox12)

OCU:

100340525

OPI:	101518253(ALOX12)

TUP:	102493396(ALOX12) 102494779

GVR:	103587106(ALOX12)

CFA:	479476(ALOX12)

CLUD:

112647510

VVP:

112924805

VLG:

121500195

NPO:	129497890(ALOX12)

AML:	100471037(ALOX12)

UMR:	103660455(ALOX12)

UAH:	113271099(ALOX12)

UAR:	123792172(ALOX12)

ELK:

111161172

LLV:	125086719 125087074

MPUF:

101684639(ALOX12)

MNP:	132003859(ALOX12)

MLK:	131815812(ALOX12)

NVS:	122906679(ALOX12)

ORO:	101379600(ALOX12)

EJU:	114225417(ALOX12)

ZCA:	113907925(ALOX12) 113939134

MLX:	117999898 117999978(ALOX12)

NSU:	110584560(ALOX12)

LWW:	102750079(ALOX12)

FCA:

101094304

PYU:	121016040(ALOX12)

PCOO:

112856976

PBG:

122484839

PVIV:

125151243(ALOX12)

LRUF:

124519666

PTG:	102969788(ALOX12)

PPAD:

109245992

PUC:

125927078

AJU:

106972408

HHV:	120231410(ALOX12)

BTA:	407169(ALOX12) 787450(ALOX12E)

BOM:	102284543(ALOX12)

BIU:	109574004(ALOX12)

BBUB:

102395651(ALOX12)

BBIS:

104993944 104993949(ALOX12)

CHX:	102187263(ALOX12)

OAS:	101113685(ALOX12)

BTAX:

128064757 128065118

ODA:	120866088(ALOX12)

CCAD:

122446320 122446338(ALOX12)

MBEZ:

129542462(ALOX12) 129542473

SSC:	100620614(ALOX12)

CFR:	102504047(ALOX12)

CBAI:

105077467(ALOX12)

CDK:	105103060(ALOX12)

VPC:	102533742(ALOX12)

BACU:

103020542(ALOX12)

BMUS:

118887046(ALOX12)

LVE:	103074060(ALOX12)

OOR:	101279538(ALOX12)

DLE:	111185974(ALOX12)

PCAD:

102977395(ALOX12)

PSIU:

116745598(ALOX12)

NASI:

112390424(ALOX12)

ECB:

100072916

EPZ:	103561430(ALOX12)

EAI:	106844160(ALOX12)

MYB:	102246619 102248372 102248722 102248980 102249269 102249301 102249603 102249899 102254447(ALOX12) 102255394

MYD:	102753778 102755565 102755847 102768484 102769301 102769599

MMYO:

118672025 118672026 118672027 118672028

MLF:	102428351 102428552 102428668 102428965 102429158 102429663 102429971 102432805 102433118 102435623

PKL:	118726716(ALOX12) 118726717 118726718 118726720 118726721 118727040 118727041 118727042

EFUS:

103296941(ALOX12) 103296942 103296943 103296944 103296945 103296946 103296985 103296986 114227056 129147359 129147360

MNA:	107544244(ALOX12)

DRO:	112308919(ALOX12)

SHON:

118979425(ALOX12)

AJM:	119037160(ALOX12)

PHAS:

123809459

MMF:	118634472 118634597 118634882

PPAM:

129072205(ALOX12)

HAI:	109394599(ALOX12)

RFQ:	117013802(ALOX12)

PALE:

102897481(ALOX12)

PGIG:

120612187(ALOX12)

PVP:	105291977(ALOX12)

RAY:	107509504(ALOX12)

MJV:

108401224

TOD:

119232717

SARA:

101547220(ALOX12) 101547484

SETR:

126011028 126027412

LAV:

100656524

TMU:

101341400

ETF:	101643858(ALOX12)

DNM:

101444550

MDO:	100015746(ALOX12) 100015831 100015867 100015906 100015945

GAS:	123243728 123247715

SHR:

AFZ:

PCW:

OAA:

MUO:	115458185(ALOX12)

GSH:	117350677(ALOX12)

DRE:	322732(alox12)

SRX:	107749792 107750578

SANH:

107669199

SGH:

107593795

CCAR:

109050063

CAUA:

113052069 113052070 113052072 113105799

CGIB:

127961063 128017081 128017082

PTET:

122348592(alox12)

LROH:

127167780(alox12)

OMC:	131543981(alox12)

PPRM:

120487640

RKG:	130102666(alox12)

MAMB:

125264591(alox12)

CIDE:

127515195

MASI:

127413609 127446982

TROS:

130570780(alox12)

TDW:	130422185(alox12)

MANU:

129441089(alox12)

IPU:	108267744 108267745(alox12)

IFU:	128610027 128610036

PHYP:

113539915

SMEO:

124387847 124387880 124388151

TFD:	113635137(alox12)

TVC:	132848618(alox12)

TRN:	134311562 134311917 134311918

AMEX:

103037595

CMAO:

118801227 118801228

EEE:

113580793

CHAR:

105889668(alox12)

TRU:

101070898

TFS:	130522950(alox12)

LCO:

104937156

NCC:

104948188

TBEN:

117497588(alox12)

CGOB:

115023433

PGEO:

117463440(alox12)

GACU:

117535413(alox12)

EMAC:

134876050(alox12)

ELY:	117272669(alox12)

EFO:	125884070(alox12)

PLEP:

121962177(alox12)

SLUC:

116043997(alox12)

ECRA:

117934769(alox12)

ESP:

116707176

PFLV:

114545687

GAT:	120822087(alox12)

PPUG:

119222432(alox12)

AFB:	129093703(alox12)

CLUM:

117747621(alox12)

PSWI:

130212060(alox12)

MSAM:

119912247(alox12)

SCHU:

122869982(alox12)

CUD:	121506630(alox12)

ALAT:

119026959(alox12)

MZE:

101479810

ONL:

100698983

OAU:	116321155(alox12)

OLA:

101174953

OML:	112155872(alox12)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122820467(alox12)

PPRL:

129378384(alox12)

CVG:

107103814

CTUL:

119775005(alox12)

GMU:	124880055(alox12)

NFU:	107384708(alox15)

KMR:	108242243(alox12)

ALIM:

106526983

NWH:	119414629(alox12)

AOCE:

111564179

MCEP:

125000804(alox12)

POV:

109637629

SSEN:

122766699(alox12)

HHIP:

117751994(alox12)

HSP:	118102186(alox12)

PPLT:

128430339(alox12)

SMAU:

118302281(alox12)

LCF:	108879679 108895226(alox12)

SDU:

111223569

SLAL:

111667993

XGL:	120797417(alox12)

PEE:	133398110(alox12)

PTAO:

133473005(alox12)

BPEC:

110170766

MALB:

109957267

BSPL:

114849198(alox12)

SJO:	128383885(alox12)

SASA:

100380705(lox12) 106608934

STRU:

115194626 115198574

OTW:	112214522(alox12) 112259738

OMY:	110500350(alox12) 110531448

OGO:	124008639 124013533(alox12)

ONE:	115122959 115133313

OKI:	109882634 109896866

OKE:	118378215 118392202(alox12)

SALP:

111952161

SNH:	120030395 120049296(alox12)

CCLU:

121554183 121571287(alox12)

ELS:

105027651

SFM:

108922837

PKI:

111846328

AANG:

118223344(alox12)

LOC:	102685586(alox12)

PSPA:

121305733 121306538

ARUT:

117426941

PSEX:

120525266(alox12) 120525267 120525269 120525271 120526494 120526784

CMK:	103190915(alox12)

RTP:

109926716

CPLA:

122544334 122544390

HOC:	132835132(alox12) 132835215

LPIC:

MMER:

XEN:

Reference

PMID:2244907

Authors

Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C, Tanabe T, Toh H

Title

Molecular cloning and expression of human arachidonate 12-lipoxygenase.

Journal

Biochem Biophys Res Commun 172:1230-5 (1990)
DOI:10.1016/0006-291X(90)91580-L

Sequence

[hsa:239]

Reference

PMID:12432922

Authors

Yoshimoto T, Takahashi Y

Title

Arachidonate 12-lipoxygenases.

Journal

Prostaglandins Other Lipid Mediat 68-69:245-62 (2002)
DOI:10.1016/S0090-6980(02)00034-5

LinkDB

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