KEGG ORTHOLOGY: K08860

ORTHOLOGY: K08860

Entry

K08860                      KO

Symbol

EIF2AK3, PERK

Name

eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]

Pathway

map04137

Mitophagy - animal

map04140

Autophagy - animal

map04141

Protein processing in endoplasmic reticulum

map04210

Apoptosis

map04214

Apoptosis - fly

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05160

Hepatitis C

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05417

Lipid and atherosclerosis

Disease

H00766

Wolcott-Rallison syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   04137 Mitophagy - animal
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09143 Cell growth and death
   04210 Apoptosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   04214 Apoptosis - fly
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05162 Measles
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05168 Herpes simplex virus 1 infection
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05012 Parkinson disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05014 Amyotrophic lateral sclerosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05020 Prion disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  PEK family [OT]
   K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3

Other DBs

GO:

0004694

Genes

HSA:	9451(EIF2AK3)

PTR:	459388(EIF2AK3)

PPS:	100981333(EIF2AK3)

GGO:	101147776(EIF2AK3)

PON:	100447385(EIF2AK3)

NLE:	100589743(EIF2AK3)

HMH:	116483180(EIF2AK3)

MCC:	699575(EIF2AK3)

MCF:	102117377(EIF2AK3)

MTHB:

126933911

MNI:	105496025(EIF2AK3)

CSAB:

103241350(EIF2AK3)

CATY:

105598836(EIF2AK3)

PANU:

101007255(EIF2AK3)

TGE:	112605118(EIF2AK3)

MLEU:

105553689(EIF2AK3)

RRO:	104674177(EIF2AK3)

RBB:	108518882(EIF2AK3)

TFN:	117062173(EIF2AK3)

PTEH:

111528197(EIF2AK3)

CANG:

105519668(EIF2AK3)

CJC:	100394186(EIF2AK3)

SBQ:	101031964(EIF2AK3)

CIMI:

108310018(EIF2AK3)

CSYR:

103264913(EIF2AK3)

MMUR:

105876638(EIF2AK3)

LCAT:

123637156(EIF2AK3)

PCOQ:

105810299(EIF2AK3)

OGA:	100945512(EIF2AK3)

MMU:	13666(Eif2ak3)

MCAL:

110296130(Eif2ak3)

RNO:	29702(Eif2ak3)

MCOC:

116099053(Eif2ak3)

ANU:	117715254(Eif2ak3)

MUN:	110561216(Eif2ak3)

CGE:	100765343(Eif2ak3)

MAUA:

101843225(Eif2ak3)

PROB:

127235535(Eif2ak3)

PLEU:

114684877(Eif2ak3)

MORG:

121437085(Eif2ak3)

MFOT:

126491041

AAMP:

119808167(Eif2ak3)

NGI:	103740131(Eif2ak3)

HGL:	101713561(Eif2ak3)

CPOC:

100725836(Eif2ak3)

DORD:

106000275(Eif2ak3)

DSP:	122116859(Eif2ak3)

PLOP:

125356191(Eif2ak3)

NCAR:

124975124

MMMA:

107159738(Eif2ak3)

OCU:

100354847

OPI:	101527487(EIF2AK3)

TUP:	102468736(EIF2AK3)

GVR:	103601352(EIF2AK3)

CFA:	475756(EIF2AK3)

CLUD:

112664364(EIF2AK3)

VVP:	112916653(EIF2AK3)

VLG:	121491533(EIF2AK3)

NPO:	129511084(EIF2AK3)

AML:	100479743(EIF2AK3)

UMR:	103671855(EIF2AK3)

UAH:	113242804(EIF2AK3)

UAR:	123799721(EIF2AK3)

ELK:

111148064

LLV:

125108962

MPUF:

101689747(EIF2AK3)

MNP:	132021375(EIF2AK3)

MLK:	131840420(EIF2AK3)

NVS:	122915073(EIF2AK3)

ORO:	101365565(EIF2AK3)

EJU:	114223436(EIF2AK3)

ZCA:	113937908(EIF2AK3)

MLX:	118007879(EIF2AK3)

NSU:	110587178(EIF2AK3)

LWW:	102733786(EIF2AK3)

FCA:	101095973(EIF2AK3)

PYU:	121044477(EIF2AK3)

PCOO:

112864237(EIF2AK3)

PBG:	122497151(EIF2AK3)

PVIV:

125162177(EIF2AK3)

LRUF:

124503015

PTG:	102963843(EIF2AK3)

PUC:

125937418

AJU:

106978143

HHV:	120245547(EIF2AK3)

BTA:	535820(EIF2AK3)

BIU:	109566145(EIF2AK3)

BBUB:

102406027(EIF2AK3)

BBIS:

104984424(EIF2AK3)

CHX:	102185575(EIF2AK3)

OAS:	101110042(EIF2AK3)

BTAX:

128056196(EIF2AK3)

ODA:	120851473(EIF2AK3)

CCAD:

122441770(EIF2AK3)

MBEZ:

129539222(EIF2AK3)

SSC:	100513348(EIF2AK3)

CFR:	102523410(EIF2AK3)

CBAI:

105072126(EIF2AK3)

CDK:	105104181(EIF2AK3)

VPC:	102527204(EIF2AK3)

BACU:

103020488(EIF2AK3)

BMUS:

118906042(EIF2AK3)

LVE:	103068759(EIF2AK3)

OOR:	101282451(EIF2AK3)

DLE:	111187362(EIF2AK3)

PCAD:

102981822(EIF2AK3)

PSIU:

116764185(EIF2AK3)

NASI:

112398926(EIF2AK3)

ECB:	100066488(EIF2AK3)

EPZ:	103549985(EIF2AK3)

EAI:	106838571(EIF2AK3)

MYB:	102256242(EIF2AK3)

MMYO:

118675238(EIF2AK3)

MLF:	102433431(EIF2AK3)

PKL:	118722681(EIF2AK3)

EFUS:

103297430(EIF2AK3)

MNA:	107528720(EIF2AK3)

DRO:	112297566(EIF2AK3)

SHON:

118975617(EIF2AK3)

AJM:	119062169(EIF2AK3)

PDIC:

114496093(EIF2AK3)

PHAS:

123816301(EIF2AK3)

MMF:	118626254(EIF2AK3)

PPAM:

129085559(EIF2AK3)

HAI:	109394047(EIF2AK3)

RFQ:	117033020(EIF2AK3)

PALE:

102894246(EIF2AK3)

PGIG:

120594611(EIF2AK3)

PVP:	105302307(EIF2AK3)

RAY:	107512376(EIF2AK3)

MJV:	108410297(EIF2AK3)

TOD:	119259152(EIF2AK3)

SARA:

101552290(EIF2AK3)

SETR:

126024479(EIF2AK3)

LAV:	100671700(EIF2AK3)

TMU:

101342812

ETF:	101641434(EIF2AK3)

DNM:	101414351(EIF2AK3)

MDO:	100029557(EIF2AK3)

GAS:	123233149(EIF2AK3)

SHR:	100915385(EIF2AK3)

AFZ:

127547478

PCW:	110202783(EIF2AK3)

OAA:	100081193(EIF2AK3)

GGA:	422930(EIF2AK3)

PCOC:

116225691(EIF2AK3)

MGP:	100538521(EIF2AK3)

CJO:	107313985(EIF2AK3)

TPAI:

128080653(EIF2AK3)

LMUT:

125692074(EIF2AK3)

NMEL:

110397823(EIF2AK3)

APLA:

101800258(EIF2AK3)

ACYG:

106033893(EIF2AK3)

CATA:

118248463(EIF2AK3)

AFUL:

116488776(EIF2AK3)

TGU:	100223479(EIF2AK3)

SCAN:

103823471(EIF2AK3)

PMOA:

120509373(EIF2AK3)

OTC:	121335198(EIF2AK3)

PRUF:

121348773(EIF2AK3)

GFR:	102039323(EIF2AK3)

OMA:	130252489(EIF2AK3)

PMAJ:

107203374(EIF2AK3)

CCW:	104690935(EIF2AK3)

CBRC:

103611209(EIF2AK3)

ZAB:	102073196(EIF2AK3)

ZLE:	135447145(EIF2AK3)

ACHL:

103811365(EIF2AK3)

SVG:	106853142(EIF2AK3)

MMEA:

130589245(EIF2AK3)

HRT:	120752906(EIF2AK3)

EGZ:	104126987(EIF2AK3)

NNI:	104018561(EIF2AK3)

PCRI:

104032583(EIF2AK3)

PLET:

104626606(EIF2AK3)

EHS:	104502589(EIF2AK3)

PCAO:

104050947(EIF2AK3)

TALA:

104368383(EIF2AK3)

PADL:

103923526(EIF2AK3)

AFOR:

103907269(EIF2AK3)

ACHC:

115343397(EIF2AK3)

HALD:

104319639(EIF2AK3)

HLE:	104840104(EIF2AK3)

AGEN:

126052990

GCL:

127015534

CCRI:

104155627(EIF2AK3)

CSTI:

104549348(EIF2AK3)

CMAC:

104484752(EIF2AK3)

MUI:	104541698(EIF2AK3)

BREG:

104629086(EIF2AK3)

FGA:	104077426(EIF2AK3)

LDI:	104347286(EIF2AK3)

MNB:	103775938(EIF2AK3)

OHA:	104329641(EIF2AK3)

NNT:	104404230(EIF2AK3)

SHAB:

115610669(EIF2AK3)

DPUB:

104296954(EIF2AK3)

PGUU:

104461655(EIF2AK3)

ACAR:

104517535(EIF2AK3)

CPEA:

104386938(EIF2AK3)

AVIT:

104277583(EIF2AK3)

CVF:	104284250(EIF2AK3)

RTD:	128910264(EIF2AK3)

CUCA:

104054939(EIF2AK3)

TEO:	104381011(EIF2AK3)

BRHI:

104501232(EIF2AK3)

AAM:	106484898(EIF2AK3)

AROW:

112965557(EIF2AK3)

NPD:	112943046(EIF2AK3)

TGT:	104567785(EIF2AK3)

DNE:	112990751(EIF2AK3)

SCAM:

104151413(EIF2AK3)

CMY:	102932471(EIF2AK3)

CCAY:

125636295(EIF2AK3)

DCC:	119854901(EIF2AK3)

CPIC:

101947852(EIF2AK3)

MRV:	120405920(EIF2AK3)

ACS:	100551680(eif2ak3)

ASAO:

132778425(EIF2AK3)

PVT:	110086330(EIF2AK3)

SUND:

121934276(EIF2AK3)

PBI:	103053678(EIF2AK3)

PMUR:

107302385(EIF2AK3)

CTIG:

120302754(EIF2AK3)

TSR:	106550345(EIF2AK3)

PGUT:

117664790(EIF2AK3)

APRI:

131197308(EIF2AK3)

PTEX:

113447249(EIF2AK3)

NSS:	113420096(EIF2AK3)

VKO:	123031874(EIF2AK3)

PMUA:

114581734(EIF2AK3)

PRAF:

128400657(EIF2AK3)

ZVI:	118094363(EIF2AK3)

HCG:	128329384(EIF2AK3)

GJA:	107118588(EIF2AK3)

STOW:

125440475(EIF2AK3)

EMC:	129337398(EIF2AK3)

XLA:	108697591 403386(eif2ak3.S)

XTR:	100190763(eif2ak3)

NPR:	108794954(EIF2AK3)

RTEM:

120924480(EIF2AK3)

BBUF:

120990444(EIF2AK3)

BGAR:

122938666(EIF2AK3)

MUO:	115461322(EIF2AK3)

GSH:	117363850(EIF2AK3)

DRE:	559564(eif2ak3)

SRX:	107733739 107747580

SANH:

107671339(eif2ak3)

SGH:	107556913 107568644

CCAR:

109045292 109089599

CAUA:

113057055 113112896

CGIB:

127970650 128026357

PTET:

122356749(eif2ak3)

LROH:

127175268(eif2ak3)

OMC:	131552683(eif2ak3)

PPRM:

120479726(eif2ak3)

RKG:	130083054(eif2ak3)

MAMB:

125276576(eif2ak3)

CIDE:

127525578

MASI:

127411854 127414221

TROS:

130558935(eif2ak3)

TDW:	130431638(eif2ak3)

MANU:

129415885(eif2ak3)

IPU:

108263654

IFU:	128605489(eif2ak3)

PHYP:

113544906(eif2ak3)

SMEO:

124402539(eif2ak3)

TFD:	113639873(eif2ak3)

TVC:	132847193(eif2ak3)

TRN:	134315102(eif2ak3)

AMEX:

103037696(eif2ak3)

CMAO:

118810293(eif2ak3)

EEE:	113579265(eif2ak3)

CHAR:

105909596(eif2ak3)

TRU:	101068654(eif2ak3)

TFS:	130539788(eif2ak3)

TNG:	GSTEN00019977G001

LCO:	104931193(eif2ak3)

NCC:	104951808(eif2ak3)

TBEN:

117469677(eif2ak3)

CGOB:

115027347(eif2ak3)

PGEO:

117467518(eif2ak3)

GACU:

117558864(eif2ak3)

EMAC:

134881598(eif2ak3)

ELY:	117267120(eif2ak3)

EFO:	125900836(eif2ak3)

PLEP:

121953982(eif2ak3)

SLUC:

116036720(eif2ak3)

ECRA:

117936371(eif2ak3)

ESP:	116686948(eif2ak3)

PFLV:

114547007(eif2ak3)

GAT:	120832780(eif2ak3)

PPUG:

119227633(eif2ak3)

AFB:	129103062(eif2ak3)

CLUM:

117751315(eif2ak3)

PSWI:

130201552(eif2ak3)

MSAM:

119910044(eif2ak3)

SCHU:

122861600(eif2ak3)

CUD:	121525897(eif2ak3)

ALAT:

119034474(eif2ak3)

MZE:	101480980(eif2ak3)

ONL:	100691545(eif2ak3)

OAU:	116322063(eif2ak3)

OLA:	101171373(eif2ak3)

OML:	112145634(eif2ak3)

CSAI:

133462047(eif2ak3)

XMA:	102220027(eif2ak3)

XCO:	114134784(eif2ak3)

XHE:	116708920(eif2ak3)

PRET:

103458264(eif2ak3)

PFOR:

103133060 103149415

PLAI:

106963566(eif2ak3)

PMEI:

106904321(eif2ak3)

GAF:	122846077(eif2ak3)

PPRL:

129377287(eif2ak3)

CVG:	107102124(eif2ak3)

CTUL:

119796208(eif2ak3)

GMU:	124855572(eif2ak3)

NFU:	107373885(eif2ak3)

KMR:	108247269(eif2ak3)

ALIM:

106523590(eif2ak3)

AOCE:

111569316(eif2ak3)

MCEP:

125023797(eif2ak3)

CSEM:

103383108(eif2ak3)

POV:	109641514(eif2ak3)

SSEN:

122782926(eif2ak3)

HHIP:

117756372(eif2ak3)

HSP:	118116960(eif2ak3)

PPLT:

128450328(eif2ak3)

SMAU:

118286030(eif2ak3)

LCF:

108889157

SDU:	111226127(eif2ak3)

SLAL:

111646809(eif2ak3)

XGL:	120795962(eif2ak3)

HCQ:	109511559(eif2ak3)

SSCV:

125980636

SBIA:

133513721(eif2ak3)

PEE:	133412640(eif2ak3)

PTAO:

133488278(eif2ak3)

BPEC:

110157424(eif2ak3)

MALB:

109962460(eif2ak3)

BSPL:

114848549(eif2ak3)

SJO:	128375933(eif2ak3)

SASA:

106611453(eif2ak3)

STRU:

115161813(eif2ak3)

OTW:	112236837(eif2ak3)

OMY:	110504273(eif2ak3)

OGO:	124046837(eif2ak3)

OKI:	109881598(eif2ak3)

OKE:	118383462(eif2ak3)

CCLU:

121555338(eif2ak3)

ELS:	105015862(eif2ak3)

SFM:	108921113(eif2ak3)

PKI:	111835392(eif2ak3)

AANG:

118226796(eif2ak3)

LOC:	102689314(eif2ak3)

PSPA:

121294698(eif2ak3) 121314894

ARUT:

117408518(eif2ak3) 117421266

PSEX:

120528022(eif2ak3)

RTP:	109928820(eif2ak3)

CPLA:

122554077(eif2ak3)

HOC:	132825534(eif2ak3)

LERI:

129702561(eif2ak3)

PMRN:

116940536(EIF2AK3)

LRJ:	133343368(EIF2AK3)

BFO:

BBEL:

SCLV:

LPIC:

DME:	Dmel_CG2087(PEK)

DER:

6552401

DSE:

6613946

DSI:	Dsimw501_GD19618(Dsim_GD19618)

DYA:	Dyak_GE25281

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23641

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ018256

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

VVE:

AROA:

SOY:

AGRG:

CSET:

LDC:

DVV:

APLN:

PPYR:

OTU:

MSEX:

DPL:	KGM_207324A

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

ACOO:

DVT:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM002650

TPAL:

CSEC:

SGRE:

BROR:

IEL:

DMK:	116921813 116921865

PVM:

113830140

PJA:	122261353 122264951

PCHN:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

LSM:

TCF:

PPOI:

RSAN:

RMP:

VDE:

VJA:

DFR:

LPOL:

PMEO:

CEL:	CELE_F46C3.1(pek-1)

CBR:	CBG_17340(Cbr-pek-1)

CRQ:	GCK72_023789

LOA:	LOAG_02433

TSP:

PVUL:

BGT:

GAE:

HRF:	124141303 125378215

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LLON:

HMG:

HSY:

ANI:	ANIA_07321

AFM:	AFUA_2G16620

ACT:	ACLA_075530

NFI:	NFIA_091920

ANG:	An04g08580

AFV:	AFLA_011624

ALUC:

AKAW2_30206S

ACHE:

ACHE_60334S

APUU:

APUU_20285S

POU:	POX_d05014

TMF:	EYB26_002316

TRG:	TRUGW13939_04994

CIM:	CIMG_09469

CPW:	CPC735_018370

ABE:

ARB_03252

TVE:

TRV_02482

AJE:	HCAG_06503

BGH:	BDBG_02782

PNO:	SNOG_07059

PTE:

PTT_19265

ARAB:

EKO05_0001683

CBET:

CB0940_06806

DDI:	DDB_G0268642

PFH:	PFHG_00358

PTI:	PHATRDRAFT_44445

GLA:	GL50803_0012089

» show all

Reference

PMID:16472110

Authors

Schroder M, Kaufman RJ

Title

Divergent roles of IRE1alpha and PERK in the unfolded protein response.

Journal

Curr Mol Med 6:5-36 (2006)
DOI:10.2174/156652406775574569

Reference

PMID:17785458

Authors

Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE

Title

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

Journal

J Biol Chem 282:31675-87 (2007)
DOI:10.1074/jbc.M704491200

Reference

PMID:10026192

Authors

Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN

Title

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.

Journal

J Biol Chem 274:5723-30 (1999)
DOI:10.1074/jbc.274.9.5723

Sequence

[hsa:9451]

LinkDB

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