KEGG ORTHOLOGY: K13097

ORTHOLOGY: K13097

Entry

K13097                      KO

Symbol

TET1

Name

methylcytosine dioxygenase [EC:1.14.11.80]

Reaction

R11030

5-methylcytosine in DNA,2-oxoglutarate:oxygen oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K13097  TET1; methylcytosine dioxygenase
   03041 Spliceosome
    K13097  TET1; methylcytosine dioxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.80  methylcytosine dioxygenase
     K13097  TET1; methylcytosine dioxygenase
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K13097  TET1; methylcytosine dioxygenase
Spliceosome [BR:ko03041]
Complex A
  Other components
   Complex A specific factors
    K13097  TET1; methylcytosine dioxygenase

Genes

HSA:	80312(TET1)

PTR:	450497(TET1)

PPS:	100994141(TET1)

GGO:	101154365(TET1)

PON:	100437556(TET1)

NLE:	100600438(TET1)

HMH:	116458720(TET1)

MCC:	693707(TET1)

MCF:	102122605(TET1)

MTHB:

126963154

MNI:	105466117(TET1)

CSAB:

103216093(TET1)

CATY:

105597454(TET1)

PANU:

101000648(TET1)

TGE:	112631203(TET1)

MLEU:

105549509(TET1)

RRO:	104671664(TET1)

RBB:	108514903(TET1)

TFN:	117082205(TET1)

PTEH:

111537923(TET1)

CANG:

105501199(TET1)

CJC:	100391032(TET1)

SBQ:	101044521(TET1)

CIMI:

108318148

CSYR:

103277271(TET1)

MMUR:

105870223(TET1)

LCAT:

123650420(TET1)

PCOQ:

105821749(TET1)

OGA:	100948153(TET1)

MMU:	52463(Tet1)

MCAL:

110303891(Tet1)

MPAH:

110326536(Tet1)

RNO:	309902(Tet1)

MCOC:

116074342(Tet1)

ANU:	117724126(Tet1)

MUN:	110557208(Tet1)

CGE:	100771765(Tet1)

MAUA:

101839115(Tet1)

PROB:

127224046(Tet1)

PLEU:

114701137(Tet1)

MORG:

121450916(Tet1)

MFOT:

126501692

AAMP:

119823886(Tet1)

NGI:	103733758(Tet1)

HGL:	101703231(Tet1)

CPOC:

100718966(Tet1)

CCAN:

109695221(Tet1)

DORD:

105986303(Tet1)

DSP:	122122308(Tet1)

PLOP:

125346385(Tet1)

NCAR:

124985301

MMMA:

107154838(Tet1)

OCU:

100347430

OPI:	101536242(TET1)

TUP:	102498328(TET1)

GVR:	103585990(TET1)

CFA:	479229(TET1)

CLUD:

112651253(TET1)

VVP:	112923783(TET1)

VLG:	121488027(TET1)

NPO:	129509780(TET1)

AML:	100477952(TET1)

UMR:	103667771(TET1)

UAH:	113259114(TET1)

UAR:	123782899(TET1)

ELK:

111144966

LLV:

125084934

MPUF:

106003357

MNP:	132016327(TET1)

MLK:	131828896(TET1)

NVS:	122900734(TET1)

ORO:	101378605(TET1)

EJU:	114214182(TET1)

ZCA:	113919689(TET1)

MLX:	118018005 118018781

NSU:	110589453(TET1)

LWW:	102734137(TET1)

FCA:	101091562(TET1)

PYU:	121036709(TET1)

PCOO:

112854753(TET1)

PBG:	122492821(TET1)

PVIV:

125148203(TET1)

LRUF:

124506854

PTG:	102959541(TET1)

PPAD:

109264335(TET1)

PUC:

125932682

AJU:

106967141

HHV:	120232488(TET1)

BTA:	513640(TET1)

BOM:	102272998(TET1)

BIU:	109553624(TET1)

BBUB:

102396328(TET1)

BBIS:

104997447(TET1)

CHX:	102186373(TET1)

OAS:	101103534(TET1)

BTAX:

128047853(TET1)

ODA:	120865194(TET1)

CCAD:

122446483(TET1)

MBEZ:

129555778(TET1)

SSC:	100625859(TET1)

CFR:	102511955(TET1)

CBAI:

105066365(TET1)

CDK:	105093883(TET1)

VPC:	102542409(TET1)

BACU:

103004922(TET1)

BMUS:

118883050(TET1)

LVE:

103076185

OOR:	101275716(TET1)

DLE:	111183443(TET1)

PCAD:

102988205(TET1)

PSIU:

116742008(TET1)

NASI:

112413578(TET1)

ECB:	100072632(TET1)

EPZ:	103557579(TET1)

EAI:	106845001(TET1)

MYB:	102261023(TET1)

MYD:	102761585(TET1)

MMYO:

118670330

MLF:	102419990(TET1)

PKL:	118719003(TET1)

EFUS:

103289600(TET1)

MNA:	107526041(TET1)

DRO:	112305623(TET1)

SHON:

118975370(TET1)

AJM:	119038161(TET1)

PDIC:

114497399(TET1)

PHAS:

123821067(TET1)

MMF:	118632499(TET1)

PPAM:

129069789(TET1)

HAI:	109372700(TET1)

RFQ:	117036040(TET1)

PALE:

102897200(TET1)

PGIG:

120609448(TET1)

PVP:	105300099(TET1)

RAY:	107501310(TET1)

MJV:	108396733(TET1)

TOD:	119234554(TET1)

SARA:

101544370(TET1)

SETR:

125995001(TET1)

LAV:	100675001(TET1)

TMU:

101362070

ETF:	101657294(TET1)

DNM:	101433103(TET1)

MDO:	100014701(TET1)

GAS:	123233032(TET1)

SHR:	100919541(TET1)

AFZ:

127552102

PCW:	110200064(TET1)

OAA:	100091768(TET1)

GGA:	423690(TET1)

PCOC:

116235004(TET1)

MGP:	100541560(TET1)

CJO:	107315707(TET1)

TPAI:

128078097(TET1)

LMUT:

125692863(TET1)

NMEL:

110399228(TET1)

APLA:

101797987(TET1)

ACYG:

106030964(TET1)

CATA:

118249363(TET1)

AFUL:

116491100(TET1)

TGU:	100218736(TET1)

LSR:	110469879(TET1)

SCAN:

103821156(TET1)

PMOA:

120496107(TET1)

OTC:	121348061(TET1)

PRUF:

121365692(TET1)

GFR:	102036059(TET1)

FAB:	101813234(TET1)

OMA:	130254837(TET1)

PHI:	102113398(TET1)

PMAJ:

107206742(TET1)

CCAE:

111931501(TET1)

CCW:	104690152(TET1)

CBRC:

103623624(TET1)

ETL:	114066280(TET1)

ZAB:	102065475(TET1)

ZLE:	135449869(TET1)

ACHL:

103800068

SVG:	106857302(TET1)

MMEA:

130580380(TET1)

HRT:	120755597(TET1)

FPG:	101919711(TET1)

FCH:	102056076(TET1)

CLV:	102089841(TET1)

EGZ:	104124627(TET1)

NNI:	104013483(TET1)

PCRI:

104025635(TET1)

PLET:

104619536(TET1)

EHS:	104510901(TET1)

PCAO:

104043512

ACUN:

113481840(TET1)

TALA:

104361177(TET1)

PADL:

103918484(TET1)

AFOR:

103908202(TET1)

ACHC:

115347979(TET1)

HALD:

104312072(TET1)

HLE:	104839591(TET1)

AGEN:

126042642

GCL:

127017542

CCRI:

104156145(TET1)

CSTI:

104560235(TET1)

CMAC:

104484543(TET1)

MUI:

104535233

BREG:

104643006(TET1)

FGA:	104073526(TET1)

GSTE:

104259158(TET1)

LDI:	104352006(TET1)

MNB:	103774983 103780713

OHA:	104338393(TET1)

NNT:	104401976(TET1)

SHAB:

115608169(TET1)

DPUB:

104306168(TET1)

PGUU:

104471706(TET1)

ACAR:

104532957

CPEA:

104386299(TET1)

AVIT:

104269294

CVF:	104294302(TET1)

RTD:	128911141(TET1)

CUCA:

104065665(TET1)

TEO:

104370857

BRHI:

104491290(TET1)

AAM:	106486962(TET1)

AROW:

112963152(TET1)

NPD:	112950202(TET1)

TGT:	104580165(TET1)

DNE:	112986863(TET1)

SCAM:

104144673(TET1)

ASN:	102387642(TET1)

AMJ:	102559455(TET1)

CPOO:

109312461(TET1)

GGN:	109290916(TET1)

PSS:	102462678(TET1)

CMY:	102932494(TET1)

DCC:	119858487(TET1)

CPIC:

101939735(TET1)

TST:	117881014(TET1)

CABI:

116833613(TET1)

MRV:	120368680(TET1)

ACS:	103279529(tet1) 107983127

ASAO:

132771193(TET1)

PVT:	110086794(TET1)

SUND:

121926392(TET1)

PBI:	103048985(TET1)

CTIG:

120299629(TET1)

TSR:	106546441(TET1)

PGUT:

117678003(TET1)

APRI:

131200647(TET1)

PTEX:

113444649(TET1)

NSS:	113415410(TET1)

VKO:	123018400(TET1)

PMUA:

114597192(TET1)

PRAF:

128413914(TET1)

ZVI:	118096505(TET1)

HCG:	128350193(TET1)

GJA:	107112689(TET1)

STOW:

125437904(TET1)

EMC:	129331663(TET1)

MUO:	115471269(TET1)

GSH:	117358823(TET1)

DRE:	101883702(tet1)

SRX:	107708452 107747454

SANH:

107678588 107690175

SGH:	107582512 107589523

CCAR:

109101144

CAUA:

113057164 113112936

CGIB:

127969921 128026402

PTET:

122356542(tet1)

LROH:

127175164(tet1)

OMC:	131551813(tet1)

PPRM:

120479303(tet1)

RKG:	130083099(tet1)

MAMB:

125276628(tet1)

MASI:

127412013 127414011

TROS:

130559588(tet1)

TDW:	130432057(tet1)

MANU:

129415640(tet1)

IPU:

108263573

IFU:

128605531

PHYP:

113539835

SMEO:

124376472(tet1)

TFD:	113639797(tet1)

TVC:	132847229(tet1)

TRN:	134315116(tet1)

AMEX:

103033153(tet1)

CMAO:

118810331(tet1)

EEE:

113587604

CHAR:

105909953(tet1)

TRU:

101065346

TFS:	130533605(tet1)

TNG:	GSTEN00016497G001

LCO:

104930132

NCC:

104946267

TBEN:

117499615(tet1)

CGOB:

115019750

PGEO:

117459736(tet1)

GACU:

117538195(tet1)

EMAC:

134858447(tet1)

ELY:	117248806(tet1)

EFO:	125903330(tet1)

PLEP:

121954351(tet1)

SLUC:

116054055(tet1)

ECRA:

117960143(tet1)

ESP:

116704931

PFLV:

114572644(tet1)

GAT:	120820909(tet1)

PPUG:

119213985(tet1)

AFB:	129091947(tet1)

CLUM:

117743821(tet1)

PSWI:

130206883(tet1)

MSAM:

119916904(tet1)

SCHU:

122884910(tet1)

CUD:	121511061(tet1)

ALAT:

119033343(tet1)

MZE:

101481549

ONL:

102081773

OAU:	116316631(tet1)

OLA:

101169512

OML:	112162155(tet1)

CSAI:

133463991(tet1)

XMA:	106699700(tet1)

XCO:

114137933

XHE:	116712546(tet1)

PRET:

103476883

PFOR:

103147714 103147743

PLAI:

106955188(tet1) 106959448

PMEI:

106907602(tet1) 106908333

GAF:	122843055(tet1)

PPRL:

129360010(tet1)

CVG:

107092736

CTUL:

119788573(tet1)

GMU:	124859149(tet1)

NFU:	107375701(tet1)

KMR:	108244348(tet1)

ALIM:

106528603(tet1)

NWH:	119412355(tet1)

AOCE:

111564364

MCEP:

125018638(tet1)

CSEM:

103387319(tet1)

POV:

109635625

SSEN:

122781627(tet1)

HHIP:

117775330(tet1)

HSP:	118118900(tet1)

PPLT:

128453286(tet1)

SMAU:

118283333(tet1)

LCF:

108884413

SDU:	111235155(tet1)

SLAL:

111654651

XGL:	120796461(tet1)

HCQ:

109509904

SSCV:

125978679

SBIA:

133509409(tet1)

PEE:	133409480(tet1)

PTAO:

133486016(tet1)

BPEC:

110164208

MALB:

109961018(tet1)

BSPL:

114870424(tet1)

SJO:	128372691(tet1)

SASA:

106577185 106613168

STRU:

115153373 115193563

OTW:	112253563 112256292(tet1)

OMY:	110502641 110530841

OGO:	124038367(tet1) 124041113

ONE:	115113089 115134959

OKI:	109879062 109899825

OKE:	118366110 118380482

SALP:

111978183

SNH:	120017848 120046715(tet1)

CCLU:

ELS:

SFM:

PKI:

AANG:

118217852(tet1)

LOC:	102689591(tet1)

PSPA:

121322046 121326180(tet1)

ARUT:

117415695 117418218

PSEX:

120516294(tet1)

LCM:	102366582(TET1)

CMK:	103182207(tet1)

» show all

Reference

PMID:21496894

Authors

Guo JU, Su Y, Zhong C, Ming GL, Song H

Title

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

Journal

Cell 145:423-34 (2011)
DOI:10.1016/j.cell.2011.03.022

Sequence

[hsa:80312] [mmu:52463]

Reference

PMID:20639862

Authors

Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y.

Title

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.

Journal

Nature 466:1129-33 (2010)
DOI:10.1038/nature09303

Sequence

[mmu:52463]

LinkDB

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