KEGG MODULE: M00376

MODULE: M00376

Entry

M00376            Pathway   Module

Name

3-Hydroxypropionate bi-cycle

Definition

(K02160+K01961+K01962+K01963) K14468 K14469 K15052 K05606 (K01847,K01848+K01849) (K14471+K14472) (K00239+K00240+K00241) K01679
K08691 K14449 K14470 K09709

Diagram

Orthology

K01961,K01962,K01963

acetyl-CoA carboxylase carboxyl transferase [EC:6.4.1.2] [RN:R00742]

K02160

acetyl-CoA carboxylase biotin carboxyl carrier protein [RN:R00742]

K14468

malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298] [RN:R00740 R09289]

K14469

acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36] [RN:R09286 R03045 R00919]

K15052

propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859]

K05606

methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]

K01847,K01848,K01849

methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]

K14471,K14472

succinyl-CoA:(S)-malate CoA transferase [EC:2.8.3.-] [RN:R00406]

K00239,K00240,K00241

succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]

K01679

fumarate hydratase [EC:4.2.1.2] [RN:R01082]

K08691

malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25] [RN:R00473 R00934 R00237]

K14449

2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]

K14470

2-methylfumaryl-CoA isomerase [EC:5.4.1.3] [RN:R09283]

K09709

3-methylfumaryl-CoA hydratase [EC:4.2.1.153] [RN:R09282]

Class

Pathway modules; Energy metabolism; Carbon fixation

Pathway

map00720

Carbon fixation pathways in prokaryotes

map01200

Carbon metabolism

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

Reaction

R00742

C00024 -> C00083

R00740

C00083 -> C00222

R09289

C00222 -> C01013

R09286

C01013 -> C05668

R03045

C05668 -> C00894

R00919

C00894 -> C00100

R01859

C00100 -> C00683

R02765

C00683 -> C01213

R00833

C01213 -> C00091

R00406

C00091 -> C00042

R02164

C00042 -> C00122

R01082

C00122 -> C00149

R00406

C00149 -> C04348

R00473

C04348 -> C00024 + C00048

R00934

C00100 -> C06027

R05076

C06027 -> C06028

R09283

C06028 -> C18323

R09282

C18323 -> C01011

R00237

C01011 -> C00024 + C00022

Compound

C00024

Acetyl-CoA

C00083

Malonyl-CoA

C00222

3-Oxopropanoate

C01013

3-Hydroxypropanoate

C05668

3-Hydroxypropionyl-CoA

C00894

Propenoyl-CoA

C00100

Propanoyl-CoA

C00683

(S)-Methylmalonyl-CoA

C01213

(R)-Methylmalonyl-CoA

C00091

Succinyl-CoA

C00042

Succinate

C00122

Fumarate

C00149

(S)-Malate

C04348

(3S)-3-Carboxy-3-hydroxypropanoyl-CoA

C00048

Glyoxylate

C06027

L-erythro-3-Methylmalyl-CoA

C06028

Mesaconyl-CoA

C18323

Mesaconyl-C4-CoA

C01011

(3S)-Citramalyl-CoA

C00022

Pyruvate

RModule

RM019

Acyl-CoA conversion via dicarboxylate semialdehyde

Comment

Organism group: photosynthetic green nonsulfur bacteria

Reference

PMID:19955419

Authors

Zarzycki J, Brecht V, Muller M, Fuchs G

Title

Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.

Journal

Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106

Reference

PMID:19103151

Authors

Xin Y, Lu YK, Fromme R, Fromme P, Blankenship RE

Title

Purification, characterization and crystallization of menaquinol:fumarate oxidoreductase from the green filamentous photosynthetic bacterium Chloroflexus aurantiacus.

Journal

Biochim Biophys Acta 1787:86-96 (2009)
DOI:10.1016/j.bbabio.2008.11.010

LinkDB

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