KEGG MODULE: M00915

MODULE: M00915

Entry

M00915            Pathway   Module

Name

Caffeine degradation, caffeine => xanthine

Definition

K21722 K21723 K21724

Diagram

Orthology

K21722

ndmA; methylxanthine N1-demethylase [EC:1.14.13.178] [RN:R07957 R07958 R07955 R07956]

K21723

ndmB; methylxanthine N3-demethylase [EC:1.14.13.179] [RN:R07954 R07939 R07961 R07962]

K21724

ndmC; 7-methylxanthine demethylase [EC:1.14.13.128] [RN:R07965 R07966]

Class

Pathway modules; Xenobiotics biodegradation; Aromatics degradation

Pathway

map00232

Caffeine metabolism

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

Reaction

R07954,R07939

C07481 -> C13747

R07957,R07958

C13747 -> C16353

R07955,R07956

C07481 -> C07480

R07961,R07962

C07480 -> C16353

R07965,R07966

C16353 -> C00385

Compound

C07481

Caffeine

C13747

1,7-Dimethylxanthine

C16353

7-Methylxanthine

C07480

Theobromine

C00385

Xanthine

Reference

PMID:22328667

Authors

Summers RM, Louie TM, Yu CL, Gakhar L, Louie KC, Subramanian M

Title

Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.

Journal

J Bacteriol 194:2041-9 (2012)
DOI:10.1128/JB.06637-11

Reference

PMID:19447909

Authors

Yu CL, Louie TM, Summers R, Kale Y, Gopishetty S, Subramanian M

Title

Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.

Journal

J Bacteriol 191:4624-32 (2009)
DOI:10.1128/JB.00409-09

LinkDB

DBGET integrated database retrieval system