KEGG   MODULE: M00977
Entry
M00977            Pathway   Module                                 
Name
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Definition
K00512 K00070 K12343 (K13369,K00089,K00037) (K04119,K10207)
Diagram
M00977

Orthology
K00512  
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32] [RN:R03783 R13218]
K00070  
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] [RN:R03327]
K12343  
3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22] [RN:R13215]
K13369  
3alpha-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.239] [RN:R13216 R04330]
K00089  
3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.357] [RN:R13216 R13217 R04330 R08963]
K00037  
3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.357] [RN:R13216 R13217]
K04119  
aldo-keto reductase family 1 member C3 [EC:1.1.1.51] [RN:R13039 R13219]
K10207  
testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64] [RN:R13219]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
Reaction
R03783  
R03327  
R13215  
R13216,R13217  
R13218  
R13039,R13219  
R04330,R08963  
Compound
C01953  Pregnenolone
C05138  17alpha-Hydroxypregnenolone
C01176  17alpha-Hydroxyprogesterone
C22831  5alpha-Pregnan-17alpha-ol-3,20-dione
C22832  5alpha-Pregnane-3alpha,17alpha-diol-20-one
C00523  Androsterone
C03852  Androstan-3alpha,17beta-diol
C03917  Dihydrotestosterone
Reference
PMID:30943210
  Authors
Miller WL, Auchus RJ
  Title
The "backdoor pathway" of androgen synthesis in human male sexual development.
  Journal
PLoS Biol 17:e3000198 (2019)
DOI:10.1371/journal.pbio.3000198
LinkDB

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