KEGG T01001: 6346

Homo sapiens (human): 6346

Entry

6346              CDS       T01001

Symbol

CCL1, I-309, P500, SCYA1, SISe, TCA3

Name

(RefSeq) C-C motif chemokine ligand 1

K05514

C-C motif chemokine 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06224  CXCR signaling (cancer)
nt06533  Chemokine signaling

Element

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

Brite

SSDB

Motif

Pfam:

IL8 Lectin_leg-like

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(34360328..34363233)

AA seq 96 aa
MQIITTALVCLLLAGMWPEDVDSKSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNE
GLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK

NT seq 291 nt +upstreamnt +downstreamnt
atgcagatcatcaccacagccctggtgtgcttgctgctagctgggatgtggccggaagat
gtggacagcaagagcatgcaggtacccttctccagatgttgcttctcatttgcggagcaa
gagattcccctgagggcaatcctgtgttacagaaataccagctccatctgctccaatgag
ggcttaatattcaagctgaagagaggcaaagaggcctgcgccttggacacagttggatgg
gttcagaggcacagaaaaatgctgaggcactgcccgtcaaaaagaaaatga

Homo sapiens (human): 6347

Entry

6347              CDS       T01001

Symbol

CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF

Name

(RefSeq) C-C motif chemokine ligand 2

K14624

C-C motif chemokine 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

hsa04621

NOD-like receptor signaling pathway

hsa04657

IL-17 signaling pathway

hsa04668

TNF signaling pathway

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa05135

Yersinia infection

hsa05142

Chagas disease

hsa05144

Malaria

hsa05163

Human cytomegalovirus infection

hsa05164

Influenza A

hsa05168

Herpes simplex virus 1 infection

hsa05171

Coronavirus disease - COVID-19

hsa05323

Rheumatoid arthritis

hsa05417

Lipid and atherosclerosis

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06224  CXCR signaling (cancer)
nt06516  TNF signaling
nt06533  Chemokine signaling

Element

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N00399

CCR2-GNB/G-PI3K-NFKB signaling pathway

N00406

HCMV US28 to GNA12/13-Rho signaling pathway

N00560

HSV gD to HVEM-NFKB signaling pathway

N01307

SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

N01770

CCR2-GNB/G-PI3K signaling pathway

Disease

H00342

Tuberculosis

H01563

HIV infection

H02563

Neural tube defects

Drug target

Bindarit:

D03116

Carlumab:

D09877

Emapticap pegol:

D12654

Pirfenidone:

D01583<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    6347 (CCL2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    6347 (CCL2)
   04061 Viral protein interaction with cytokine and cytokine receptor
    6347 (CCL2)
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    6347 (CCL2)
   04657 IL-17 signaling pathway
    6347 (CCL2)
   04062 Chemokine signaling pathway
    6347 (CCL2)
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    6347 (CCL2)
   05164 Influenza A
    6347 (CCL2)
   05168 Herpes simplex virus 1 infection
    6347 (CCL2)
   05163 Human cytomegalovirus infection
    6347 (CCL2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    6347 (CCL2)
  09174 Infectious disease: parasitic
   05144 Malaria
    6347 (CCL2)
   05142 Chagas disease
    6347 (CCL2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    6347 (CCL2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    6347 (CCL2)
   05418 Fluid shear stress and atherosclerosis
    6347 (CCL2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    6347 (CCL2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    6347 (CCL2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6347 (CCL2)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Chemokines
   6347 (CCL2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Chemokines
   6347 (CCL2)

SSDB

Motif

Pfam:

IL8 CXCL16

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:34255285..34257203

AA seq 99 aa
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

NT seq 300 nt +upstreamnt +downstreamnt
atgaaagtctctgccgcccttctgtgcctgctgctcatagcagccaccttcattccccaa
gggctcgctcagccagatgcaatcaatgccccagtcacctgctgttataacttcaccaat
aggaagatctcagtgcagaggctcgcgagctatagaagaatcaccagcagcaagtgtccc
aaagaagctgtgatcttcaagaccattgtggccaaggagatctgtgctgaccccaagcag
aagtgggttcaggattccatggaccacctggacaagcaaacccaaactccgaagacttga

Homo sapiens (human): 6348

Entry

6348              CDS       T01001

Symbol

CCL3, G0S19-1, LD78, LD78ALPHA, MIP-1-alpha, MIP1A, SCI, SCYA3

Name

(RefSeq) C-C motif chemokine ligand 3

K05408

C-C motif chemokine 3

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

hsa04620

Toll-like receptor signaling pathway

hsa05142

Chagas disease

hsa05163

Human cytomegalovirus infection

hsa05323

Rheumatoid arthritis

hsa05417

Lipid and atherosclerosis

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06533  Chemokine signaling

Element

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N00406

HCMV US28 to GNA12/13-Rho signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

Disease

H01563

HIV infection

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    6348 (CCL3)
   04061 Viral protein interaction with cytokine and cytokine receptor
    6348 (CCL3)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    6348 (CCL3)
   04062 Chemokine signaling pathway
    6348 (CCL3)
09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    6348 (CCL3)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    6348 (CCL3)
  09163 Immune disease
   05323 Rheumatoid arthritis
    6348 (CCL3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    6348 (CCL3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    6348 (CCL3)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6348 (CCL3)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Chemokines
   6348 (CCL3)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Chemokines
   6348 (CCL3)

SSDB

Motif

Pfam:

IL8 CXCL16

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(36088256..36090143)

AA seq 92 aa
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKP
GVIFLTKRSRQVCADPSEEWVQKYVSDLELSA

NT seq 279 nt +upstreamnt +downstreamnt
atgcaggtctccactgctgcccttgctgtcctcctctgcaccatggctctctgcaaccag
ttctctgcatcacttgctgctgacacgccgaccgcctgctgcttcagctacacctcccgg
cagattccacagaatttcatagctgactactttgagacgagcagccagtgctccaagccc
ggtgtcatcttcctaaccaagcgaagccggcaggtctgtgctgaccccagtgaggagtgg
gtccagaaatatgtcagcgacctggagctgagtgcctga

Homo sapiens (human): 6351

Entry

6351              CDS       T01001

Symbol

CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4

Name

(RefSeq) C-C motif chemokine ligand 4

K12964

C-C motif chemokine 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04620

Toll-like receptor signaling pathway

hsa04623

Cytosolic DNA-sensing pathway

hsa05163

Human cytomegalovirus infection

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06533  Chemokine signaling

Element

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N00406

HCMV US28 to GNA12/13-Rho signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    6351 (CCL4)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    6351 (CCL4)
   04061 Viral protein interaction with cytokine and cytokine receptor
    6351 (CCL4)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    6351 (CCL4)
   04623 Cytosolic DNA-sensing pathway
    6351 (CCL4)
   04062 Chemokine signaling pathway
    6351 (CCL4)
09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    6351 (CCL4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    6351 (CCL4)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Chemokines
   6351 (CCL4)

SSDB

Motif

Pfam:

IL8 CXCL16

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:36103827..36105614

AA seq 92 aa
MKLCVTVLSLLMLVAAFCSPALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQ
PAVVFQTKRSKQVCADPSESWVQEYVYDLELN

NT seq 279 nt +upstreamnt +downstreamnt
atgaagctctgcgtgactgtcctgtctctcctcatgctagtagctgccttctgctctcca
gcgctctcagcaccaatgggctcagaccctcccaccgcctgctgcttttcttacaccgcg
aggaagcttcctcgcaactttgtggtagattactatgagaccagcagcctctgctcccag
ccagctgtggtattccaaaccaaaagaagcaagcaagtctgtgctgatcccagtgaatcc
tgggtccaggagtacgtgtatgacctggaactgaactga

Homo sapiens (human): 3576

Entry

3576              CDS       T01001

Symbol

CXCL8, GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8

Name

(RefSeq) C-X-C motif chemokine ligand 8

K10030

interleukin 8

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04218

Cellular senescence

hsa04620

Toll-like receptor signaling pathway

hsa04621

NOD-like receptor signaling pathway

hsa04622

RIG-I-like receptor signaling pathway

hsa04657

IL-17 signaling pathway

hsa04932

Non-alcoholic fatty liver disease

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa04936

Alcoholic liver disease

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

hsa05130

Pathogenic Escherichia coli infection

hsa05131

Shigellosis

hsa05132

Salmonella infection

hsa05133

Pertussis

hsa05134

Legionellosis

hsa05135

Yersinia infection

hsa05142

Chagas disease

hsa05144

Malaria

hsa05146

Amoebiasis

hsa05161

Hepatitis B

hsa05163

Human cytomegalovirus infection

hsa05164

Influenza A

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05171

Coronavirus disease - COVID-19

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05219

Bladder cancer

hsa05323

Rheumatoid arthritis

hsa05417

Lipid and atherosclerosis

Network

nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06224  CXCR signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06533  Chemokine signaling

Element

N00140

FUS-DDIT3 fusion to NFKB-mediated transcription

N00152

CXCR-GNB/G-ERK signaling pathway

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N00154

CXCR-GNB/G-PI3K-AKT signaling pathway

N00544

HBV HBx to CREB-mediated transcription

N01307

SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

Drug target

Adakitug:

D12656

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    3576 (CXCL8)
   04072 Phospholipase D signaling pathway
    3576 (CXCL8)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3576 (CXCL8)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3576 (CXCL8)
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    3576 (CXCL8)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3576 (CXCL8)
   04621 NOD-like receptor signaling pathway
    3576 (CXCL8)
   04622 RIG-I-like receptor signaling pathway
    3576 (CXCL8)
   04657 IL-17 signaling pathway
    3576 (CXCL8)
   04062 Chemokine signaling pathway
    3576 (CXCL8)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3576 (CXCL8)
   05202 Transcriptional misregulation in cancer
    3576 (CXCL8)
  09162 Cancer: specific types
   05219 Bladder cancer
    3576 (CXCL8)
  09172 Infectious disease: viral
   05161 Hepatitis B
    3576 (CXCL8)
   05171 Coronavirus disease - COVID-19
    3576 (CXCL8)
   05164 Influenza A
    3576 (CXCL8)
   05163 Human cytomegalovirus infection
    3576 (CXCL8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3576 (CXCL8)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    3576 (CXCL8)
   05130 Pathogenic Escherichia coli infection
    3576 (CXCL8)
   05132 Salmonella infection
    3576 (CXCL8)
   05131 Shigellosis
    3576 (CXCL8)
   05135 Yersinia infection
    3576 (CXCL8)
   05133 Pertussis
    3576 (CXCL8)
   05134 Legionellosis
    3576 (CXCL8)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3576 (CXCL8)
   05144 Malaria
    3576 (CXCL8)
   05142 Chagas disease
    3576 (CXCL8)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3576 (CXCL8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3576 (CXCL8)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    3576 (CXCL8)
   04932 Non-alcoholic fatty liver disease
    3576 (CXCL8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3576 (CXCL8)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3576 (CXCL8)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3576 (CXCL8)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Chemokines
   3576 (CXCL8)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Chemokines
   3576 (CXCL8)

SSDB

Motif

Pfam:

IL8 CXCL16

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

4:73740569..73743716

AA seq 99 aa
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

NT seq 300 nt +upstreamnt +downstreamnt
atgacttccaagctggccgtggctctcttggcagccttcctgatttctgcagctctgtgt
gaaggtgcagttttgccaaggagtgctaaagaacttagatgtcagtgcataaagacatac
tccaaacctttccaccccaaatttatcaaagaactgagagtgattgagagtggaccacac
tgcgccaacacagaaattattgtaaagctttctgatggaagagagctctgtctggacccc
aaggaaaactgggtgcagagggttgtggagaagtttttgaagagggctgagaattcataa

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