KEGG PATHWAY: ko05204

PATHWAY: ko05204

Entry

ko05204                     Pathway

Name

Chemical carcinogenesis - DNA adducts

Description

It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Mutations cause an undefined number of cell changes, translated into aberrant protein expression and in changes in cell cycle control.

Class

Human Diseases; Cancer: overview

Pathway map

ko05204

Chemical carcinogenesis - DNA adducts

Orthology

K00622

arylamine N-acetyltransferase [EC:2.3.1.5]

K07409

cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]

K01014

aryl sulfotransferase [EC:2.8.2.1]

K07408

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

K07410

cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]

K07413

cytochrome P450 family 2 subfamily C [EC:1.14.14.1]

K17718

cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]

K17719

cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]

K17720

cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]

K17721

cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]

K17689

cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

K01253

microsomal epoxide hydrolase [EC:3.3.2.9]

K00799

glutathione S-transferase [EC:2.5.1.18]

K23790

glutathione S-transferase P [EC:2.5.1.18]

K13299

glutathione S-transferase kappa 1 [EC:2.5.1.18]

K04097

prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]

K11822

bile-salt sulfotransferase [EC:2.8.2.14]

K07424

cytochrome P450 family 3 subfamily A [EC:1.14.14.1]

K17690

cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]

K17691

cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]

K17692

cytochrome P450 family 3 subfamily A43 [EC:1.14.14.1]

K11987

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

K17683

cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]

K17685

cytochrome P450 family 2 subfamily A13 [EC:1.14.14.1]

K00089

3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]

K15680

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

K00079

carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]

K00699

glucuronosyltransferase [EC:2.4.1.17]

K07415

cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]

Compound

C00027

Hydrogen peroxide

C03012

Naphthalene-1,2-diol

C03621

N-Acetoxy-4-aminobiphenyl

C03622

N-Hydroxy-4-aminobiphenyl

C06268

Chromium

C06547

Ethylene

C06548

Ethylene oxide

C06752

1,2-Dichloroethane

C06754

Chloroacetaldehyde

C06793

Vinyl chloride

C06800

Aflatoxin B1

C07122

Melphalan

C07535

Benzo[a]pyrene

C07641

Thiotepa

C10998

4-Aminobiphenyl

C14556

9-Hydroxybenzo[a]pyrene

C14704

N-Nitrosodimethylamine

C14783

1,2-Naphthoquinone

C14849

Benzo[a]pyrene-9,10-oxide

C14850

Benzo[a]pyrene-7,8-oxide

C14851

Benzo[a]pyrene-4,5-oxide

C14852

Benzo[a]pyrene-7,8-dihydrodiol

C14853

Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide

C14854

9-Hydroxybenzo[a]pyrene-4,5-oxide

C14855

4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene

C14856

7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene

C14874

Glutathione episulfonium ion

C16038

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

C16453

4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone

C16844

Hydroxyl radical

C19164

Sulfur mustard

C19180

2-Amino-3-methylimidazo[4,5-f]quinoline

C19255

MeIQx

C19488

7,12-Dimethylbenz[a]anthracene

C19489

1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene

C19490

trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene

C19525

Sudan I

C19559

(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol

C19561

7-Hydroxymethyl-12-methylbenz[a]anthracene

C19562

7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate

C19563

4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone

C19564

4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone

C19565

4-Hydroxy-1-(3-pyridinyl)-1-butanone

C19566

4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone

C19567

4-Oxo-1-(3-pyridyl)-1-butanone

C19568

N-Nitrosomethanamine

C19569

3-Succinoylpyridine

C19574

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

C19577

1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol

C19578

5-(3-Pyridyl)-2-hydroxytetrahydrofuran

C19579

gamma-Hydroxy-3-pyridinebutanoate

C19580

alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol

C19581

alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol

C19582

1-(3-Pyridinyl)-1,4-butanediol

C19586

Aflatoxin B1-exo-8,9-epoxide

C19602

4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone

C19603

4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol

C19605

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide

C19606

NNAL-N-glucuronide

C20280

1-Phenylazo-2,6-dihydroxynaphthalene

C20281

1-(4-Hydroxyphenylazo)-2-naphthol

C20282

1-(4-Hydroxyphenylazo)-naphthalene-2,6-diol

C20283

1-(3,4-Dihydroxyphenylazo)-2-naphthol

C20284

Benzenediazonium

C20285

4-Acetylaminobiphenyl

C20286

2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine

C20287

2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine

C20288

N-Sulfonyloxy-PhIP

C20289

N-Hydroxy-IQ

C20290

N-Acetoxy-IQ

C20291

N-Hydroxy-MeIQx

C20293

N-Acetoxy-MeIQx

C20301

alpha-Hydroxy-NDMA

C20302

Methyldiazonium ion

C20303

Chloroethylene oxide

C20304

S-(2-Chloroethyl)glutathione

C20305

1,2-Dichloroethanol

C20306

Methyldiazohydroxide

Reference

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Authors

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Title

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Journal

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Title

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Journal

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Authors

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Title

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Journal

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Authors

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Title

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Journal

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Title

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Journal

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Journal

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Reference

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Authors

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Title

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Journal

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Title

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Journal

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Journal

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Title

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Journal

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Reference

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