| mGluR5-Ca2+ -apoptotic pathway |
| Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway |
| VGCC-Ca2+ -apoptotic pathway |
| Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway |
| Transport of calcium |
| Scrapie conformation PrPSc to transport of calcium |
| 26S proteasome-mediated protein degradation |
| Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation |
| PERK-ATF4 signaling pathway |
| Scrapie conformation PrPSc to PERK-ATF4 signaling pathway |
| PRNP-PI3K-NOX2 signaling pathway |
| Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway |
| Anterograde axonal transport |
| Oligomeric conformation PrPc to anterograde axonal transport |
| Notch signaling pathway |
| Scrapie conformation PrPSc to Notch singling pathway |
