KEGG   PATHWAY: alab04150
Entry
alab04150                   Pathway                                
Name
mTOR signaling pathway - Apis laboriosa (Himalayan honeybee)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
alab04150  mTOR signaling pathway
alab04150

Organism
Apis laboriosa (Himalayan honeybee) [GN:alab]
Gene
122716273  Y+L amino acid transporter 2 [KO:K13780]
122718924  large neutral amino acids transporter small subunit 2 isoform X1 [KO:K13780]
122715067  neutral and basic amino acid transport protein rBAT-like [KO:K06519]
122713724  sodium-coupled neutral amino acid transporter 9 homolog [KO:K14995]
122713496  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
122713995  V-type proton ATPase subunit B [KO:K02147]
122715243  V-type proton ATPase subunit C [KO:K02148]
122713215  V-type proton ATPase subunit D 1 [KO:K02149]
122720204  V-type proton ATPase subunit E [KO:K02150]
122716220  V-type proton ATPase subunit F [KO:K02151]
122720010  V-type proton ATPase subunit G [KO:K02152]
122718652  V-type proton ATPase subunit H isoform X1 [KO:K02144]
122720410  ragulator complex protein LAMTOR1 [KO:K20397]
122713555  ragulator complex protein LAMTOR2 [KO:K20398]
122721001  ragulator complex protein LAMTOR3-A [KO:K04370]
122711244  ragulator complex protein LAMTOR4 homolog isoform X1 [KO:K20399]
122713760  uncharacterized protein LOC122713760 [KO:K16344]
122716571  probable dihydroxyacetone kinase [KO:K09594]
122716660  folliculin-interacting protein 1 [KO:K20401]
122714184  ras-related GTP-binding protein A [KO:K16185]
122714068  ras-related GTP-binding protein D [KO:K16186]
122717903  GATOR complex protein MIOS-B isoform X1 [KO:K20407]
122714898  nucleoporin SEH1 [KO:K14299]
122716016  GATOR complex protein WDR24 isoform X1 [KO:K20408]
122718304  GATOR complex protein WDR59 isoform X1 [KO:K20409]
122715373  protein SEC13 homolog [KO:K14004]
122712129  GATOR complex protein Iml1 isoform X1 [KO:K20404]
122718800  GATOR complex protein NPRL2 [KO:K20405]
122715021  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
122717674  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
122713645  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
122715449  uncharacterized protein LOC122715449 [KO:K16184]
122718206  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122715371  target of rapamycin complex subunit lst8 isoform X1 [KO:K08266]
122719863  TELO2-interacting protein 1 homolog [KO:K20403]
122712616  restin homolog isoform X1 [KO:K10421]
122711866  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
122712392  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
122710852  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
122717755  eukaryotic translation initiation factor 4E-1A [KO:K03259]
122710808  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
122712705  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
122712481  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
122711518  40S ribosomal protein S6 [KO:K02991]
122716997  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
122715793  protein Mo25 isoform X1 [KO:K08272]
122710303  hamartin [KO:K07206]
122713643  tuberin isoform X1 [KO:K07207]
122713821  TBC1 domain family member 7 [KO:K20396]
122715829  GTP-binding protein Rheb homolog [KO:K07208]
122718343  protein Wnt-1 [KO:K03209]
122716851  protein Wnt-1-like isoform X1 [KO:K00408]
122713452  protein Wnt-5b-like isoform X1 [KO:K00444]
122718377  protein Wnt-6-like [KO:K00445]
122720198  protein Wnt-7b-like [KO:K00572]
122718376  protein Wnt-10b-like [KO:K01357]
122714693  protein Wnt-11b-1-like isoform X1 [KO:K01384]
122720706  frizzled-2 [KO:K02432]
122720346  frizzled-2 [KO:K02375]
122717385  low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
122716198  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
122713388  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
122717408  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122719403  LIRP-like [KO:K04526]
122717260  insulin-like peptide receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122713199  insulin-like peptide receptor [KO:K04527] [EC:2.7.10.1]
122719471  growth factor receptor-bound protein 2 [KO:K04364]
122720953  protein son of sevenless isoform X1 [KO:K03099]
122717496  ras-like protein 1 [KO:K07827]
122716406  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
122712800  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
122712727  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122715352  ribosomal protein S6 kinase 2 beta-like isoform X1 [KO:K04373] [EC:2.7.11.1]
122712169  insulin receptor substrate 1 isoform X1 [KO:K16172]
122719497  uncharacterized protein LOC122719497 isoform X1 [KO:K02649]
122718194  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122716345  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122718631  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
122718319  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122716378  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
122720839  rapamycin-insensitive companion of mTOR [KO:K08267]
122720801  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
122718279  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
alab00561  Glycerolipid metabolism
alab04140  Autophagy - animal
KO pathway
ko04150   
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