KEGG   PATHWAY: bbuf04150
Entry
bbuf04150                   Pathway                                
Name
mTOR signaling pathway - Bufo bufo (common toad)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bbuf04150  mTOR signaling pathway
bbuf04150

Organism
Bufo bufo (common toad) [GN:bbuf]
Gene
120980566  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
120981108  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
120992100  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
120982091  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
120994374  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120990507  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
120986332  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
120999952  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
121001263  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
120981701  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
121004558  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
120985284  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
120977241  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
120977308  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
120978869  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
121001832  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
120996594  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
120982187  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
120989848  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
120986532  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
120995099  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
121008262  FLCN; folliculin [KO:K09594]
120977203  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
120990081  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
120977225  ras-related GTP-binding protein A [KO:K16185]
120995328  RRAGC; ras-related GTP-binding protein C [KO:K16186]
120996945  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
120995221  SESN2; sestrin-2 [KO:K20394]
120988915  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
120995556  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
121000661  MIOS; GATOR complex protein MIOS [KO:K20407]
121001627  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
121008181  WDR24; GATOR complex protein WDR24 [KO:K20408]
120980469  WDR59; GATOR complex protein WDR59 [KO:K20409]
120979564  SEC13; protein SEC13 homolog [KO:K14004]
120988762  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
120985534  GATOR complex protein NPRL2 [KO:K20405]
120978634  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
121007648  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
120992178  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
121001616  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
121006133  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
121002400  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
120999412  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121004454  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
121007705  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
121008999  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
121004691  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
120988596  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
121000774  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
120997291  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
121002766  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
121003249  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
120988658  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
120995463  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
120989680  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
120989830  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
120998007  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
120981521  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
120986578  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
120995444  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121003072  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
120996084  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
120989249  RPS6; 40S ribosomal protein S6 [KO:K02991]
121006001  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
121008495  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
120989457  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
120997651  calcium-binding protein 39 [KO:K08272]
120984655  calcium-binding protein 39-like [KO:K08272]
120996233  CAB39L; calcium-binding protein 39-like [KO:K08272]
120992156  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
120978491  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121009179  TSC1; hamartin [KO:K07206]
121008869  TSC2; tuberin isoform X1 [KO:K07207]
121001440  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
121002681  RHEB; GTP-binding protein Rheb [KO:K07208]
121004823  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
120993632  WNT1; proto-oncogene Wnt-1 [KO:K03209]
120985636  WNT2; protein Wnt-2 [KO:K00182]
120994966  WNT2B; protein Wnt-2b [KO:K00182]
121000918  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
121003955  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120998093  WNT4; protein Wnt-4 [KO:K00408]
120979057  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121004359  WNT5B; protein Wnt-5b [KO:K00444]
121007458  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
121006222  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
120977292  protein Wnt-7a-like isoform X1 [KO:K00572]
120979189  protein Wnt-7a [KO:K00572]
121005648  WNT8B; protein Wnt-8b [KO:K00714]
120979000  WNT8A; protein Wnt-8a [KO:K00714]
121000915  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121004265  WNT9B; protein Wnt-9b [KO:K01064]
121008474  WNT10A; protein Wnt-10a [KO:K01357]
120995956  WNT10B; protein Wnt-10b [KO:K01357]
120977092  protein Wnt-11b [KO:K01384]
120996505  WNT11; protein Wnt-11 [KO:K01384]
120981837  WNT16; protein Wnt-16 [KO:K01558]
121007879  FZD7; frizzled-7 [KO:K02432]
121000605  FZD1; frizzled-1 [KO:K02432]
121004647  FZD2; frizzled-2 [KO:K02235]
120997176  FZD3; frizzled-3 isoform X1 [KO:K02329]
120996454  FZD4; frizzled-4 [KO:K02354]
121007772  FZD5; frizzled-5 [KO:K02375]
121002764  FZD8; frizzled-8 [KO:K02375]
121001434  FZD6; frizzled-6 [KO:K02376]
120994788  FZD9; frizzled-9 [KO:K02842]
120988649  FZD10; frizzled-10 [KO:K02842]
121004793  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
120980132  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
120997631  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120998042  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
120986709  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
120994338  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120977834  tumor necrosis factor-like [KO:K03156]
121003720  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120986314  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120980007  INS; insulin [KO:K04526]
120979169  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120989403  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
120985975  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121003787  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
120998761  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120982400  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120981053  HRAS; GTPase HRas isoform X1 [KO:K02833]
121004973  KRAS; GTPase KRas isoform X1 [KO:K07827]
121001799  GTPase HRas-like [KO:K07827]
120994996  NRAS; GTPase NRas isoform X1 [KO:K07828]
121005721  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120978563  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
120986019  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120989541  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120988704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121009180  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
120994838  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
120995204  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120997794  IRS1; insulin receptor substrate 1 [KO:K16172]
120986661  insulin receptor substrate 1-like [KO:K16172]
120989607  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120992399  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120978688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120997646  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120997902  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120996957  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
121004607  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121007440  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
120982548  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121009286  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121003342  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121009502  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
120992166  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
120980830  PRR5L; proline-rich protein 5-like [KO:K20411]
121006482  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
120979702  RHOA; transforming protein RhoA [KO:K04513]
121009570  transforming protein RhoA-like [KO:K04513]
120994972  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
121004965  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121009043  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121003127  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120998512  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bbuf00561  Glycerolipid metabolism
bbuf04010  MAPK signaling pathway
bbuf04140  Autophagy - animal
bbuf04810  Regulation of actin cytoskeleton
bbuf04910  Insulin signaling pathway
KO pathway
ko04150   
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