KEGG   PATHWAY: breg04150
Entry
breg04150                   Pathway                                
Name
mTOR signaling pathway - Balearica regulorum gibbericeps (East African grey crowned-crane)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
breg04150  mTOR signaling pathway
breg04150

Organism
Balearica regulorum gibbericeps (East African grey crowned-crane) [GN:breg]
Gene
104636781  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104639606  SLC38A9; putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
104643560  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104629916  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104637246  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104638158  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104633007  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104630812  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104636265  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104641855  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
104643168  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104641622  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
104631046  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104638743  FLCN; folliculin [KO:K09594]
104634973  FNIP1; folliculin-interacting protein 1 [KO:K20400]
104643330  FNIP2; folliculin-interacting protein 2 [KO:K20401]
104630758  ras-related GTP-binding protein A [KO:K16185]
104641477  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104639360  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104639001  LOW QUALITY PROTEIN: GATS-like protein 1 [KO:K23081]
104635999  MIOS; WD repeat-containing protein mio [KO:K20407]
104636752  SEH1L; nucleoporin SEH1 [KO:K14299]
104632998  WDR24; WD repeat-containing protein 24 [KO:K20408]
104633056  WDR59; WD repeat-containing protein 59 [KO:K20409]
104630839  SEC13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
104635594  DEPDC5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
104638676  NPRL2; nitrogen permease regulator 2-like protein [KO:K20405]
104633271  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
104640402  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
104633489  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104638702  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
104637165  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104642267  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
104644045  DEP domain-containing mTOR-interacting protein [KO:K20402]
104643920  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104632701  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
104633964  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104629425  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104643717  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
104629939  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
104629640  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104640452  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104629538  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104635648  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104630460  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
104629104  eukaryotic translation initiation factor 4E [KO:K03259]
104630184  eukaryotic translation initiation factor 4E-like [KO:K03259]
104629851  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
104639745  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
104630348  RPS6; 40S ribosomal protein S6 [KO:K02991]
104629957  STRADA; STE20-related kinase adapter protein alpha [KO:K08271]
104636576  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
104641582  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104641288  CAB39; calcium-binding protein 39 [KO:K08272]
104641474  CAB39L; calcium-binding protein 39-like [KO:K08272]
104630680  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104630334  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104642858  TSC1; hamartin isoform X1 [KO:K07206]
104629116  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104634463  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
104635108  RHEB; GTP-binding protein Rheb [KO:K07208]
104636302  WNT2; protein Wnt-2 [KO:K00182]
104642654  protein Wnt-3a [KO:K00312]
104640067  proto-oncogene Wnt-3 [KO:K00312]
104630187  WNT4; protein Wnt-4 [KO:K00408]
104639746  protein Wnt-4-like [KO:K00408]
104638281  WNT5B; protein Wnt-5b [KO:K00444]
104634340  WNT6; protein Wnt-6 [KO:K00445]
104639670  WNT7A; protein Wnt-7a [KO:K00572]
104640417  WNT7B; protein Wnt-7b [KO:K00572]
104643026  WNT8B; protein Wnt-8b [KO:K00714]
104640103  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
104636524  WNT9A; protein Wnt-9a [KO:K01064]
104637768  WNT9B; protein Wnt-9b [KO:K01064]
104630962  WNT10A; protein Wnt-10a [KO:K01357]
104641184  protein Wnt-11b-like [KO:K01384]
104638910  WNT11; protein Wnt-11 [KO:K01384]
104635211  WNT16; protein Wnt-16 [KO:K01558]
104637779  LOW QUALITY PROTEIN: frizzled-7-like [KO:K02432]
104631408  FZD2; frizzled-2 [KO:K02235]
104638475  FZD3; frizzled-3 [KO:K02329]
104631254  FZD4; frizzled-4 [KO:K02354]
104642916  frizzled-5-like [KO:K02375]
104632047  FZD6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
104637643  FZD10; frizzled-10 [KO:K02842]
104641202  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104638587  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
104632165  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
104630471  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104630091  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104639471  INS; insulin [KO:K04526]
104631537  IGF1; insulin-like growth factor I [KO:K05459]
104638295  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
104636598  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104638031  SH3D21; SH3 domain-containing protein 21 isoform X1 [KO:K04364]
104643786  SOS1; son of sevenless homolog 1 [KO:K03099]
104634926  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104631064  HRAS; GTPase HRas [KO:K02833]
104634279  KRAS; GTPase KRas isoform X1 [KO:K07827]
104635027  GTPase NRas [KO:K07828]
104629609  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104632729  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
104639949  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104629471  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104641266  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
104636508  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104633418  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104629838  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104639356  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104639857  IRS1; insulin receptor substrate 1 [KO:K16172]
104641031  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104634362  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
104634486  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104643797  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
104636125  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104636734  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104637393  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104633922  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104630150  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104632555  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104635541  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104640250  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104642304  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104629032  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
104637793  proline-rich protein 5-like [KO:K20411]
104641328  RHOA; transforming protein RhoA [KO:K04513]
104633825  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104636346  SGK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
breg00561  Glycerolipid metabolism
breg04010  MAPK signaling pathway
breg04140  Autophagy - animal
breg04810  Regulation of actin cytoskeleton
breg04910  Insulin signaling pathway
KO pathway
ko04150   
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