KEGG   PATHWAY: btax04150
Entry
btax04150                   Pathway                                
Name
mTOR signaling pathway - Budorcas taxicolor (takin)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04150  mTOR signaling pathway
btax04150

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128063115  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
128068796  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
128066067  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
128048003  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
128056419  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
128052140  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
128056097  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
128059241  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
128043334  V-type proton ATPase subunit D-like [KO:K02149]
128070330  V-type proton ATPase subunit D-like [KO:K02149]
128054110  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
128056156  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
128047802  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
128046717  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
128052365  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
128061750  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
128055983  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
128059159  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
128060035  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
128045176  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
128049714  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
128043180  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
128045106  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
128064832  FLCN; folliculin [KO:K09594]
128051730  FNIP1; folliculin-interacting protein 1 [KO:K20400]
128062152  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
128070299  RRAGB; ras-related GTP-binding protein B [KO:K16185]
128052244  RRAGA; ras-related GTP-binding protein A [KO:K16185]
128044652  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
128053058  RRAGD; ras-related GTP-binding protein D [KO:K16186]
128068389  SESN2; LOW QUALITY PROTEIN: sestrin-2 [KO:K20394]
128062333  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
128062332  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
128046578  MIOS; GATOR complex protein MIOS [KO:K20407]
128067580  SEH1L; nucleoporin SEH1 [KO:K14299]
128068834  WDR24; GATOR complex protein WDR24 [KO:K20408]
128063188  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
128047416  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
128062635  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
128054655  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
128066199  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
128059172  S-phase kinase-associated protein 2-like [KO:K03875]
128066055  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
128067570  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
128064589  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
128063236  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128059129  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
128065538  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
128043948  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
128058312  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
128062004  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
128046462  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
128058899  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
128067276  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
128055492  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
128062633  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
128064482  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
128059988  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
128068203  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
128056769  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
128050970  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
128061904  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
128049601  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
128064578  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128068526  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
128047355  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
128067666  eukaryotic translation initiation factor 4B-like [KO:K03258]
128052165  RPS6; 40S ribosomal protein S6 [KO:K02991]
128055152  40S ribosomal protein S6 [KO:K02991]
128064476  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
128067585  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
128050902  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
128057764  CAB39L; calcium-binding protein 39-like [KO:K08272]
128065238  CAB39; calcium-binding protein 39 [KO:K08272]
128044580  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
128065926  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
128056632  TSC1; hamartin isoform X1 [KO:K07206]
128043920  TSC2; tuberin isoform X1 [KO:K07207]
128056235  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
128046520  RHEB; GTP-binding protein Rheb [KO:K07208]
128047579  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
128048884  WNT1; proto-oncogene Wnt-1 [KO:K03209]
128044967  WNT2B; protein Wnt-2b [KO:K00182]
128046758  WNT2; protein Wnt-2 [KO:K00182]
128051398  WNT3A; protein Wnt-3a [KO:K00312]
128065491  WNT3; proto-oncogene Wnt-3 [KO:K00312]
128064929  WNT4; protein Wnt-4 [KO:K00408]
128051429  WNT5A; protein Wnt-5a [KO:K00444]
128047274  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
128043631  WNT6; protein Wnt-6 [KO:K00445]
128054243  WNT7A; protein Wnt-7a [KO:K00572]
128048826  WNT7B; protein Wnt-7b [KO:K00572]
128051617  WNT8A; protein Wnt-8a [KO:K00714]
128067661  WNT8B; protein Wnt-8b [KO:K00714]
128051174  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
128065456  WNT9B; protein Wnt-9b [KO:K01064]
128043684  WNT10A; protein Wnt-10a [KO:K01357]
128048628  WNT10B; protein Wnt-10b [KO:K01357]
128060249  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
128046389  WNT16; protein Wnt-16 [KO:K01558]
128070496  FZD7; frizzled-7 [KO:K02432]
128046799  FZD1; frizzled-1 [KO:K02432]
128065200  FZD2; frizzled-2 [KO:K02235]
128052483  FZD3; frizzled-3 [KO:K02329]
128068654  FZD4; frizzled-4 [KO:K02354]
128071105  frizzled-5 [KO:K02375]
128058547  FZD8; frizzled-8 [KO:K02375]
128065941  FZD5; frizzled-5 [KO:K02375]
128059374  FZD6; frizzled-6 [KO:K02376]
128043337  FZD9; frizzled-9 [KO:K02842]
128062458  FZD10; frizzled-10 [KO:K02842]
128069156  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
128048011  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
128064845  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
128045751  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
128061181  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128056772  TNF; tumor necrosis factor [KO:K03156]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128069208  INS; insulin [KO:K04526]
128048032  IGF1; insulin-like growth factor I [KO:K05459]
128050313  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
128066571  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128046969  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128063260  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
128069871  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
128070615  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
128053046  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
128069000  IRS1; insulin receptor substrate 1 [KO:K16172]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128068055  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128060129  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128055321  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
128066010  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
128060829  PRR5L; proline-rich protein 5-like [KO:K20411]
128047816  PRR5; proline-rich protein 5 [KO:K20411]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128053038  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
btax00561  Glycerolipid metabolism
btax04010  MAPK signaling pathway
btax04140  Autophagy - animal
btax04151  PI3K-Akt signaling pathway
btax04152  AMPK signaling pathway
btax04810  Regulation of actin cytoskeleton
btax04910  Insulin signaling pathway
KO pathway
ko04150   
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