KEGG   PATHWAY: bvan04150
Entry
bvan04150                   Pathway                                
Name
mTOR signaling pathway - Bombus vancouverensis nearcticus
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bvan04150  mTOR signaling pathway
bvan04150

Organism
Bombus vancouverensis nearcticus [GN:bvan]
Gene
117163803  Y+L amino acid transporter 2 [KO:K13780]
117159649  large neutral amino acids transporter small subunit 2 [KO:K13780]
117159398  neutral and basic amino acid transport protein rBAT isoform X1 [KO:K06519]
117157291  sodium-coupled neutral amino acid transporter 9 homolog [KO:K14995]
117158755  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117164481  V-type proton ATPase subunit B [KO:K02147]
117161939  V-type proton ATPase subunit C isoform X1 [KO:K02148]
117158784  V-type proton ATPase subunit D [KO:K02149]
117156340  V-type proton ATPase subunit E [KO:K02150]
117163807  V-type proton ATPase subunit F [KO:K02151]
117159629  V-type proton ATPase subunit G [KO:K02152]
117159533  V-type proton ATPase subunit H isoform X1 [KO:K02144]
117159753  ragulator complex protein LAMTOR1 [KO:K20397]
117166581  ragulator complex protein LAMTOR2 [KO:K20398]
117157060  ragulator complex protein LAMTOR3-A [KO:K04370]
117155296  ragulator complex protein LAMTOR4 homolog [KO:K20399]
117157187  uncharacterized protein LOC117157187 [KO:K16344]
117153254  triokinase/FMN cyclase [KO:K09594]
117155443  folliculin-interacting protein 1 [KO:K20401]
117158668  ras-related GTP-binding protein A [KO:K16185]
117158645  ras-related GTP-binding protein D isoform X1 [KO:K16186]
117156520  GATOR complex protein MIOS-B [KO:K20407]
117161991  nucleoporin SEH1 isoform X1 [KO:K14299]
117161874  GATOR complex protein WDR24 [KO:K20408]
117160996  GATOR complex protein WDR59 isoform X1 [KO:K20409]
117159339  protein SEC13 homolog [KO:K14004]
117154680  GATOR complex protein Iml1 isoform X1 [KO:K20404]
117161746  GATOR complex protein NPRL2 isoform X1 [KO:K20405]
117165991  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
117163542  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117156569  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117160116  uncharacterized protein LOC117160116 [KO:K16184]
117156580  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117156313  target of rapamycin complex subunit lst8 [KO:K08266]
117155838  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
117154074  restin homolog isoform X1 [KO:K10421]
117158406  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
117165874  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
117161625  eukaryotic translation initiation factor 4E-1A-like isoform X1 [KO:K03259]
117162675  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117153323  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
117154215  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
117159606  eukaryotic translation initiation factor 4B [KO:K03258]
117160909  40S ribosomal protein S6-like [KO:K02991]
117156816  40S ribosomal protein S6-like isoform X1 [KO:K02991]
117156937  40S ribosomal protein S6-like isoform X1 [KO:K02991]
117156988  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117159017  protein Mo25 isoform X1 [KO:K08272]
117155223  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117153348  hamartin isoform X1 [KO:K07206]
117166694  tuberin [KO:K07207]
117157204  TBC1 domain family member 7 [KO:K20396]
117154577  GTP-binding protein Rheb homolog [KO:K07208]
117154909  protein Wnt-1-like [KO:K03209]
117160584  protein Wnt-1-like isoform X1 [KO:K00408]
117163452  protein Wnt-5b-like isoform X1 [KO:K00444]
117153536  protein Wnt-6-like isoform X1 [KO:K00445]
117156238  protein Wnt-7b isoform X1 [KO:K00572]
117153551  protein Wnt-10b-like [KO:K01357]
117166124  protein Wnt-11b-2-like isoform X1 [KO:K01384]
117164108  frizzled-7-B [KO:K02432]
117158389  frizzled-2-like [KO:K02375]
117166031  low-density lipoprotein receptor-related protein 6 [KO:K03068]
117166421  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
117159276  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
117158776  protein kinase shaggy-like isoform X1 [KO:K03083] [EC:2.7.11.26]
117157967  inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K07209] [EC:2.7.11.10]
117155227  LIRP-like [KO:K04526]
117164661  insulin-like growth factor I, juvenile form [KO:K05459]
117155628  insulin-like peptide receptor [KO:K04527] [EC:2.7.10.1]
117158905  insulin-like peptide receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117155177  protein enhancer of sevenless 2B [KO:K04364]
117156944  protein son of sevenless isoform X1 [KO:K03099]
117158146  ras-like protein 1 [KO:K07827]
117153956  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
117161448  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
117154079  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117164497  ribosomal protein S6 kinase 2 beta-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117154788  insulin receptor substrate 1-B isoform X1 [KO:K16172]
117156020  uncharacterized protein LOC117156020 isoform X1 [KO:K02649]
117166710  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117164124  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117153635  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
117156503  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117153962  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
117156996  rapamycin-insensitive companion of mTOR [KO:K08267]
117154406  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
117153141  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bvan00561  Glycerolipid metabolism
bvan04140  Autophagy - animal
KO pathway
ko04150   
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