KEGG   PATHWAY: cclu00600
Entry
cclu00600                   Pathway                                
Name
Sphingolipid metabolism - Coregonus clupeaformis (lake whitefish)
Class
Metabolism; Lipid metabolism
Pathway map
cclu00600  Sphingolipid metabolism
cclu00600

Module
cclu_M00066  Lactosylceramide biosynthesis [PATH:cclu00600]
cclu_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:cclu00600]
cclu_M00094  Ceramide biosynthesis [PATH:cclu00600]
cclu_M00099  Sphingosine biosynthesis [PATH:cclu00600]
cclu_M00100  Sphingosine degradation [PATH:cclu00600]
Other DBs
GO: 0006665
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121581935  serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
121581939  sptlc1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
121556401  serine palmitoyltransferase 3-like [KO:K00654] [EC:2.3.1.50]
121539642  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
121548508  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
121552183  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
121544601  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
121580984  3-ketodihydrosphingosine reductase isoform X1 [KO:K04708] [EC:1.1.1.102]
121535293  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
121533626  ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
121576828  ceramide synthase 1 isoform X1 [KO:K04710] [EC:2.3.1.299]
121571422  cers2a; ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
121533593  ceramide synthase 2 isoform X1 [KO:K24621] [EC:2.3.1.297]
121534588  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
121586323  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
121543165  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
121580774  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
123481026  ceramide synthase 2-like isoform X1 [KO:K24621] [EC:2.3.1.297]
123481019  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
121548345  ceramide synthase 2 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
121538600  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
121574729  ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
121552238  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
121536805  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
121545346  ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
123487891  LOW QUALITY PROTEIN: acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
121547342  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
121532702  acer1; alkaline ceramidase 1 isoform X1 [KO:K01441] [EC:3.5.1.23]
121562226  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
121571179  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
123484447  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
121579794  alkaline ceramidase 3-like isoform X1 [KO:K04711] [EC:3.5.1.-]
121573595  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
121539035  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
121580178  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
121553176  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
121570237  sphingolipid delta(4)-desaturase DES1-like isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
121547340  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
121532937  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
121553764  phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
121554420  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
121580660  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
121542062  smpd1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
121578359  smpd2b; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
121556577  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
121531793  sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
121558168  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
121576722  sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
121582569  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
121541626  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
121583961  sphingomyelin phosphodiesterase 4-like [KO:K12353] [EC:3.1.4.12]
121562914  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
121543278  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
123481444  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
121548035  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
121546755  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
121532046  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
121537866  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
123486691  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
121540089  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
121585099  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
121582835  phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
121581873  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
121581077  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
121573493  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
121540339  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
121533331  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
121560181  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
121533506  phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
121551315  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
121535566  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
121568857  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
121539811  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
121533224  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
121539359  sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
121552384  sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
121544457  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
121567705  sphingosine-1-phosphate phosphatase 2-like isoform X1 [KO:K04717] [EC:3.1.3.-]
121532654  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121551044  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121570397  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121543826  sphk2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121568859  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
121553655  sgpl1; sphingosine-1-phosphate lyase 1 isoform X2 [KO:K01634] [EC:4.1.2.27]
121583630  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
121573357  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
121543171  lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
123485634  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
123482953  non-lysosomal glucosylceramidase-like isoform X1 [KO:K17108] [EC:3.2.1.45]
121540492  beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
121533898  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
121538624  beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
121545315  beta-1,4-galactosyltransferase 5-like isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
121550285  LOW QUALITY PROTEIN: beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
121562104  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
121563379  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
121539552  galcb; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
121544678  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
121584518  gal3st1a; galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
121574212  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
121551236  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
121551487  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
121570515  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
121531984  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
121585558  LOW QUALITY PROTEIN: sialidase-1-like [KO:K01186] [EC:3.2.1.18]
121571461  sialidase-1 [KO:K01186] [EC:3.2.1.18]
121579532  sialidase-3-like isoform X1 [KO:K12357] [EC:3.2.1.18]
121541895  neu3.1; sialidase-3.1 [KO:K12357] [EC:3.2.1.18]
121566988  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
121540726  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
121575259  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
121577619  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
121537887  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [KO:K00725] [EC:2.4.1.92]
121582159  beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
121531499  hexa; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
121541471  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
121530843  ganglioside GM2 activator [KO:K12383]
121538819  ganglioside GM2 activator-like [KO:K12383]
121584883  sftpbb; surfactant protein Bb [KO:K12382]
121530951  prosaposin isoform X1 [KO:K12382]
121547773  prosaposin isoform X1 [KO:K12382]
121578397  prosaposin [KO:K12382]
121541771  sftpba; prosaposin isoform X1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cclu00260  Glycine, serine and threonine metabolism
cclu00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cclu00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cclu00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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