KEGG   PATHWAY: cpoc04150
Entry
cpoc04150                   Pathway                                
Name
mTOR signaling pathway - Cavia porcellus (domestic guinea pig)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpoc04150  mTOR signaling pathway
cpoc04150

Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100729845  Slc7a5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
100731455  Slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
100733132  Slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
100733879  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100726524  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100724011  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100716597  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
100725980  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X2 [KO:K02148]
100716088  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
100725691  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
100722091  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
100730842  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
100712974  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100723558  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
100712761  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
100716527  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100726527  Lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
100720456  Lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
100727855  Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
100717094  Lamtor4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399]
100721571  Lamtor5; ragulator complex protein LAMTOR5 isoform X2 [KO:K16344]
100729986  Flcn; folliculin [KO:K09594]
100717527  Fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
100724233  Fnip2; LOW QUALITY PROTEIN: folliculin-interacting protein 2 [KO:K20401]
100724885  ras-related GTP-binding protein B isoform X1 [KO:K16185]
100713018  Rraga; ras-related GTP-binding protein A [KO:K16185]
100729527  Rragd; ras-related GTP-binding protein D [KO:K16186]
100715370  Rragc; ras-related GTP-binding protein C [KO:K16186]
100719606  Sesn2; sestrin-2 [KO:K20394]
100724420  Castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X2 [KO:K23080]
100724971  Castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100714787  Mios; GATOR complex protein MIOS [KO:K20407]
100731812  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
100717603  Wdr24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
100715424  Wdr59; LOW QUALITY PROTEIN: GATOR complex protein WDR59 [KO:K20409]
100716969  Sec13; protein SEC13 homolog isoform X1 [KO:K14004]
100728656  Depdc5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404]
100718057  Nprl2; GATOR complex protein NPRL2 [KO:K20405]
100735976  Nprl3; GATOR complex protein NPRL3 isoform X2 [KO:K20406]
100720705  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100718418  Rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100729707  Rptor; regulatory-associated protein of mTOR [KO:K07204]
100722328  Akt1s1; proline-rich AKT1 substrate 1 isoform X3 [KO:K16184]
100724938  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100721956  Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
100732619  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
100728749  Telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
100730540  Tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
100723601  Clip1; CAP-Gly domain-containing linker protein 1 isoform X13 [KO:K10421]
100733471  Grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
100733777  Lpin3; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
100716519  Lpin2; phosphatidate phosphatase LPIN2 isoform X3 [KO:K15728] [EC:3.1.3.4]
100718634  Lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
100719170  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100720864  Ulk2; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
100733182  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100718596  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
100724587  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100733247  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100727216  Rps6kb1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100722430  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100714022  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
100735681  Eif4b; eukaryotic translation initiation factor 4B isoform X4 [KO:K03258]
100729373  Rps6; 40S ribosomal protein S6 [KO:K02991]
100732268  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100712796  Stradb; STE20-related kinase adapter protein beta [KO:K17532]
100730854  Stk11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
100719727  Cab39l; calcium-binding protein 39-like isoform X1 [KO:K08272]
100713955  Cab39; calcium-binding protein 39 [KO:K08272]
100713170  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100714483  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100732297  Tsc1; hamartin [KO:K07206]
100731690  Tsc2; tuberin isoform X1 [KO:K07207]
100716907  Tbc1d7; TBC1 domain family member 7 [KO:K20396]
100734252  Rheb; GTP-binding protein Rheb [KO:K07208]
100714502  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
100717026  Wnt1; LOW QUALITY PROTEIN: proto-oncogene Wnt-1 [KO:K03209]
100714996  Wnt2b; protein Wnt-2b [KO:K00182]
100719346  Wnt2; protein Wnt-2 [KO:K00182]
100726694  Wnt3a; protein Wnt-3a [KO:K00312]
100734613  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
100724855  Wnt4; protein Wnt-4 isoform X1 [KO:K00408]
100715484  Wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
100723890  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
100713618  Wnt6; protein Wnt-6 [KO:K00445]
100726062  Wnt7b; protein Wnt-7b [KO:K00572]
100719106  Wnt7a; protein Wnt-7a [KO:K00572]
100725534  Wnt8a; protein Wnt-8a [KO:K00714]
100724403  Wnt8b; protein Wnt-8b [KO:K00714]
100726329  Wnt9a; protein Wnt-9a [KO:K01064]
100729157  Wnt9b; protein Wnt-9b [KO:K01064]
100713337  Wnt10a; protein Wnt-10a [KO:K01357]
100728910  Wnt10b; protein Wnt-10b [KO:K01357]
100718108  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
100721822  Wnt16; protein Wnt-16 [KO:K01558]
100735394  Fzd7; frizzled-7 [KO:K02432]
100730489  Fzd1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
100726820  Fzd2; frizzled-2 [KO:K02235]
100716417  Fzd3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
100714941  Fzd4; frizzled-4 [KO:K02354]
100728348  Fzd5; frizzled-5 [KO:K02375]
100719748  Fzd6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
100735834  Fzd9; frizzled-9 [KO:K02842]
100731601  Fzd10; frizzled-10 [KO:K02842]
100714196  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100735282  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100728748  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100717450  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100723761  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100714392  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100135630  Tnf; tumor necrosis factor [KO:K03156]
100713890  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X3 [KO:K03158]
100724538  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100379579  Ins; insulin precursor [KO:K04526]
100135551  Igf1; insulin-like growth factor I precursor [KO:K05459]
100718484  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100734840  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100715453  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
100721165  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100726398  Sos2; son of sevenless homolog 2 [KO:K03099]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100717765  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100728923  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100728619  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100729439  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100721226  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
100731385  Rps6ka6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100716939  Irs1; insulin receptor substrate 1 [KO:K16172]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100723659  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100735138  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100726357  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100730188  Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
100715888  Rictor; rapamycin-insensitive companion of mTOR [KO:K08267]
101787415  Prr5; proline-rich protein 5 [KO:K20411]
100724728  Prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
100733542  Rhoa; transforming protein RhoA [KO:K04513]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100720058  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cpoc00561  Glycerolipid metabolism
cpoc04010  MAPK signaling pathway
cpoc04140  Autophagy - animal
cpoc04151  PI3K-Akt signaling pathway
cpoc04152  AMPK signaling pathway
cpoc04810  Regulation of actin cytoskeleton
cpoc04910  Insulin signaling pathway
KO pathway
ko04150   
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