KEGG   PATHWAY: dfr04150
Entry
dfr04150                    Pathway                                
Name
mTOR signaling pathway - Dermatophagoides farinae (American house dust mite)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dfr04150  mTOR signaling pathway
dfr04150

Organism
Dermatophagoides farinae (American house dust mite) [GN:dfr]
Gene
124498526  Y+L amino acid transporter 2-like [KO:K13780]
124492450  large neutral amino acids transporter small subunit 1-like [KO:K13780]
124495037  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
124490497  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
124491361  V-type proton ATPase subunit B [KO:K02147]
124500059  V-type proton ATPase subunit C-like [KO:K02148]
124499668  V-type proton ATPase subunit D-like isoform X1 [KO:K02149]
124495240  V-type proton ATPase subunit D-like [KO:K02149]
124493937  V-type proton ATPase subunit E-like [KO:K02150]
124498435  V-type proton ATPase subunit F-like [KO:K02151]
124494154  V-type proton ATPase subunit G-like [KO:K02152]
124491830  LOW QUALITY PROTEIN: V-type proton ATPase subunit H-like [KO:K02144]
124491156  uncharacterized protein LOC124491156 [KO:K20397]
124496604  ragulator complex protein LAMTOR2 homolog [KO:K20398]
124500054  ragulator complex protein LAMTOR3-like [KO:K04370]
124490089  uncharacterized protein LOC124490089 [KO:K16344]
124498326  ras-related GTP-binding protein A-like [KO:K16185]
124492904  ras-related GTP-binding protein A-like isoform X1 [KO:K16185]
124495183  ras-related GTP-binding protein C-like [KO:K16186]
124492152  GATOR complex protein MIOS-like [KO:K20407]
124492467  nucleoporin SEH1-like [KO:K14299]
124500229  GATOR complex protein WDR24-like [KO:K20408]
124492415  LOW QUALITY PROTEIN: GATOR complex protein WDR59-like [KO:K20409]
124492138  protein SEC13 homolog [KO:K14004]
124492917  LOW QUALITY PROTEIN: GATOR complex protein Iml1-like [KO:K20404]
124495631  GATOR complex protein NPRL2-like [KO:K20405]
124500547  GATOR complex protein NPRL3-like [KO:K20406]
124493940  regulatory-associated protein of mTOR-like [KO:K07204]
124498599  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
124493140  telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
124494033  TELO2-interacting protein 1 homolog [KO:K20403]
124495619  LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
124499780  serine/threonine-protein kinase unc-51-like [KO:K08269] [EC:2.7.11.1]
124496964  eukaryotic translation initiation factor 4E-binding protein 3-like [KO:K07205]
124490765  uncharacterized protein LOC124490765 [KO:K03259]
124491068  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
124496985  eukaryotic translation initiation factor 4E-like [KO:K03259]
124497538  eukaryotic translation initiation factor 4E1-like [KO:K03259]
124491762  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
124492264  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
124493575  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
124497029  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
124490568  filaggrin-like [KO:K03258]
124493555  40S ribosomal protein S6-like [KO:K02991]
124494706  STE20-related kinase adapter protein alpha-like [KO:K08271]
124495369  STE20-related kinase adapter protein alpha-like [KO:K08271]
124496052  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
124496060  serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
124498002  protein Mo25-like [KO:K08272]
124492037  uncharacterized protein LOC124492037 isoform X1 [KO:K08272]
124494777  uncharacterized protein LOC124494777 [KO:K08272]
124495999  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
124494305  LOW QUALITY PROTEIN: CBL-interacting protein kinase 28-like [KO:K07198] [EC:2.7.11.31]
124494576  serine/threonine-protein kinase atg1-like [KO:K07198] [EC:2.7.11.31]
124494873  serine/threonine-protein kinase HRK1-like [KO:K07198] [EC:2.7.11.31]
124492232  uncharacterized protein LOC124492232 [KO:K07206]
124490107  LOW QUALITY PROTEIN: tuberin-like [KO:K07207]
124495857  TBC1 domain family member 7-like [KO:K20396]
124494174  GTP-binding protein Rheb-like [KO:K07208]
124499712  protein Wnt-1-like [KO:K03209]
124498808  protein Wnt-5b-like [KO:K00444]
124499713  protein Wnt-1-like [KO:K00445]
124499096  protein Wnt-7b-like [KO:K00572]
124494086  protein Wnt-4-like isoform X1 [KO:K00572]
124496691  LOW QUALITY PROTEIN: protein Wnt-8a-like [KO:K00714]
124490208  frizzled-7-B-like [KO:K02432]
124499442  uncharacterized protein LOC124499442 [KO:K02354]
124499784  LOW QUALITY PROTEIN: frizzled-5-like [KO:K02375]
124491512  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
124496716  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
124496847  glycogen synthase kinase-3-like [KO:K03083] [EC:2.7.11.26]
124492644  glycogen synthase kinase-3-like [KO:K03083] [EC:2.7.11.26]
124499075  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K07209] [EC:2.7.11.10]
124490982  uncharacterized protein LOC124490982 [KO:K04527] [EC:2.7.10.1]
124497719  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
124496719  growth factor receptor-bound protein 2-like [KO:K04364]
124489795  son of sevenless homolog 1-like [KO:K03099]
124490454  GTPase HRas [KO:K07827]
124498924  serine/threonine-protein kinase A-Raf-like [KO:K04365] [EC:2.7.11.1]
124495554  M-phase inducer phosphatase-like [KO:K04365] [EC:2.7.11.1]
124494243  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
124497899  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124499869  ribosomal protein S6 kinase 2 beta-like [KO:K04373] [EC:2.7.11.1]
124490550  ras guanine nucleotide exchange factor B-like [KO:K02649]
124497231  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
124500072  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
124495310  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
124496801  uncharacterized protein LOC124496801 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124496663  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
124495108  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124493206  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
124489877  LOW QUALITY PROTEIN: rapamycin-insensitive companion of mTOR-like [KO:K08267]
124493815  proline-rich protein 5-like [KO:K20411]
124491432  ras-like GTP-binding protein RHO [KO:K04513]
124500064  rho-related protein racM-like [KO:K04513]
124495890  LOW QUALITY PROTEIN: calcium-dependent protein kinase C-like [KO:K02677] [EC:2.7.11.13]
124500567  protein kinase C, brain isozyme-like [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dfr00561  Glycerolipid metabolism
dfr04140  Autophagy - animal
KO pathway
ko04150   
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