KEGG   PATHWAY: nlu04150
Entry
nlu04150                    Pathway                                
Name
mTOR signaling pathway - Nilaparvata lugens (brown planthopper)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
nlu04150  mTOR signaling pathway
nlu04150

Organism
Nilaparvata lugens (brown planthopper) [GN:nlu]
Gene
111051694  Y+L amino acid transporter 2-like isoform X1 [KO:K13780]
111055257  large neutral amino acids transporter small subunit 1 [KO:K13780]
111047591  large neutral amino acids transporter small subunit 1 [KO:K13780]
111056721  sodium-coupled neutral amino acid transporter 9 homolog isoform X1 [KO:K14995]
111053189  V-type proton ATPase catalytic subunit A isoform X2 [KO:K02145] [EC:7.1.2.2]
111058393  V-type proton ATPase subunit B isoform X1 [KO:K02147]
111043995  V-type proton ATPase subunit C [KO:K02148]
111056177  V-type proton ATPase subunit D [KO:K02149]
120352526  V-type proton ATPase subunit E 2-like [KO:K02150]
111046646  V-type proton ATPase subunit E [KO:K02150]
111049145  V-type proton ATPase subunit E [KO:K02150]
111053502  V-type proton ATPase subunit F 1 [KO:K02151]
120350711  V-type proton ATPase subunit G-like [KO:K02152]
120355178  V-type proton ATPase subunit G-like [KO:K02152]
120355273  V-type proton ATPase subunit G-like [KO:K02152]
111054955  V-type proton ATPase subunit G isoform X1 [KO:K02152]
111055144  V-type proton ATPase subunit G-like [KO:K02152]
111059876  V-type proton ATPase subunit G [KO:K02152]
111043438  LOW QUALITY PROTEIN: V-type proton ATPase subunit H [KO:K02144]
111051852  ragulator complex protein LAMTOR1 [KO:K20397]
111048222  ragulator complex protein LAMTOR2 [KO:K20398]
111055790  ragulator complex protein LAMTOR3-A [KO:K04370]
111063142  uncharacterized protein LOC111063142 [KO:K16344]
111054904  folliculin [KO:K09594]
111053648  folliculin-interacting protein 1 isoform X1 [KO:K20401]
111057975  ras-related GTP-binding protein A-like [KO:K16185]
111043341  ras-related GTP-binding protein C [KO:K16186]
111052717  GATOR complex protein MIOS-B [KO:K20407]
111058266  nucleoporin SEH1 [KO:K14299]
111049193  GATOR complex protein WDR24 [KO:K20408]
111051483  LOW QUALITY PROTEIN: GATOR complex protein WDR59 [KO:K20409]
111058081  protein SEC13 homolog [KO:K14004]
111054732  GATOR complex protein Iml1 isoform X1 [KO:K20404]
120350028  LOW QUALITY PROTEIN: GATOR complex protein NPRL2-like [KO:K20405]
111045712  GATOR complex protein NPRL3 isoform X2 [KO:K20406]
111057013  S-phase kinase-associated protein 2 isoform X3 [KO:K03875]
111047193  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
111046277  uncharacterized protein LOC111046277 [KO:K16184]
111055114  LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111050572  target of rapamycin complex subunit lst8 [KO:K08266]
111057381  uncharacterized protein LOC111057381 [KO:K20403]
111052030  CAP-Gly domain-containing linker protein 2 isoform X4 [KO:K10421]
111058914  phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
111054141  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
111050963  eukaryotic translation initiation factor 4E [KO:K03259]
111059932  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111044135  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
111044823  eukaryotic translation initiation factor 4B isoform X4 [KO:K03258]
111057526  40S ribosomal protein S6 [KO:K02991]
111061639  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
120354289  STE20-related kinase adapter protein alpha-like [KO:K08271]
111043217  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
111047415  protein Mo25 isoform X1 [KO:K08272]
111047682  protein Mo25-like [KO:K08272]
111057138  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
111058116  hamartin [KO:K07206]
111055061  LOW QUALITY PROTEIN: tuberin [KO:K07207]
111051335  GTP-binding protein Rheb homolog [KO:K07208]
111043445  GTP-binding protein Rheb-like [KO:K07208]
111048926  GTP-binding protein Rheb homolog [KO:K07208]
111054151  protein wingless [KO:K03209]
111044633  protein Wnt-4 isoform X3 [KO:K00408]
111050093  protein Wnt-5b [KO:K00444]
111056936  protein Wnt-6 isoform X1 [KO:K00445]
111047173  protein Wnt-7b [KO:K00572]
111054000  protein Wnt-10a [KO:K01357]
111050235  protein Wnt-11 isoform X1 [KO:K01384]
111046051  frizzled-2 [KO:K02432]
111056665  frizzled-4-like [KO:K02354]
111049114  frizzled-5 [KO:K02375]
111051780  frizzled-10 [KO:K02842]
111049074  low-density lipoprotein receptor-related protein 6 [KO:K03068]
111046026  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
111053552  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111053537  LIRP [KO:K04526]
111053538  uncharacterized protein LOC111053538 [KO:K04526]
111046284  LIRP [KO:K04526]
111047475  insulin receptor [KO:K04527] [EC:2.7.10.1]
111044882  growth factor receptor-bound protein 2 [KO:K04364]
111063372  uncharacterized protein LOC111063372 isoform X1 [KO:K03099]
111056735  protein son of sevenless isoform X1 [KO:K03099]
111054979  GTPase HRas [KO:K07827]
111057721  GTPase HRas-like [KO:K07827]
120352284  raf homolog serine/threonine-protein kinase Raf-like [KO:K04365] [EC:2.7.11.1]
111060035  raf homolog serine/threonine-protein kinase Raf-like [KO:K04365] [EC:2.7.11.1]
120353160  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
111058821  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111043261  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111048142  ribosomal protein S6 kinase 2 beta isoform X1 [KO:K04373] [EC:2.7.11.1]
111053511  insulin receptor substrate 1-B isoform X1 [KO:K16172]
111047698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111054338  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111047065  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120350564  putative 3-phosphoinositide-dependent protein kinase 2 isoform X1 [KO:K06276] [EC:2.7.11.1]
111059847  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111057761  LOW QUALITY PROTEIN: RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111048096  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111051206  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
111057219  uncharacterized protein LOC111057219 [KO:K08267]
111050345  ras-like GTP-binding protein Rho1 [KO:K04513]
120353579  ras-like GTP-binding protein Rho1 [KO:K04513]
111052561  calcium-dependent protein kinase C isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
nlu00561  Glycerolipid metabolism
nlu04140  Autophagy - animal
KO pathway
ko04150   
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