KEGG   PATHWAY: otc04150
Entry
otc04150                    Pathway                                
Name
mTOR signaling pathway - Onychostruthus taczanowskii (white-rumped snowfinch)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
otc04150  mTOR signaling pathway
otc04150

Organism
Onychostruthus taczanowskii (white-rumped snowfinch) [GN:otc]
Gene
121333808  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
121336823  4F2 cell-surface antigen heavy chain-like [KO:K06519]
121346627  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
121339217  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121338567  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
121346823  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
121348269  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
121340276  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
121344418  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
121344526  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
121332880  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
121337179  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
121337014  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
121344613  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
121340185  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
121345420  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
121338570  ragulator complex protein LAMTOR1-like [KO:K20397]
121332143  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
121346582  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
121345554  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
121334572  FLCN; folliculin [KO:K09594]
121332454  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
121348410  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
121346499  ras-related GTP-binding protein A [KO:K16185]
121340050  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
121342842  RRAGC; ras-related GTP-binding protein C [KO:K16186]
121336021  SESN2; sestrin-2 [KO:K20394]
121344411  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
121346883  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
121338066  MIOS; GATOR complex protein MIOS [KO:K20407]
121336921  WDR24; GATOR complex protein WDR24 [KO:K20408]
121333926  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
121347110  SEC13; protein SEC13 homolog [KO:K14004]
121344398  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
121347173  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
121334410  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
121343558  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
121348374  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
121338255  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
121343885  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121337412  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
121333099  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
121334331  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
121338019  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
121343849  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
121338847  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
121339725  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
121345235  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
121343750  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
121333204  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
121339005  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121345739  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
121346813  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
121346555  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
121336580  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
121332354  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
121339681  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121346999  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121342838  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121333048  RPS6; 40S ribosomal protein S6 [KO:K02991]
121347568  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
121335474  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
121342002  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
121342119  CAB39; calcium-binding protein 39 [KO:K08272]
121337252  CAB39L; calcium-binding protein 39-like [KO:K08272]
121344962  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121334108  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
121336850  TSC1; hamartin isoform X1 [KO:K07206]
121334348  TSC2; tuberin isoform X1 [KO:K07207]
121340427  TBC1 domain family member 7 [KO:K20396]
121337985  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
121336062  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
121334262  WNT1; proto-oncogene Wnt-1 [KO:K03209]
121347973  WNT2B; protein Wnt-2b [KO:K00182]
121344803  WNT2; protein Wnt-2 [KO:K00182]
121338058  WNT3A; protein Wnt-3a [KO:K00312]
121332977  WNT3; proto-oncogene Wnt-3 [KO:K00312]
121333066  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
121347270  WNT5A; protein Wnt-5a [KO:K00444]
121332778  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
121335765  WNT6; protein Wnt-6 [KO:K00445]
121332811  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
121333290  WNT7A; protein Wnt-7a [KO:K00572]
121341786  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
121332390  WNT8A; protein Wnt-8a [KO:K00714]
121338169  WNT9A; protein Wnt-9a [KO:K01064]
121332985  WNT9B; protein Wnt-9b [KO:K01064]
121335749  WNT10A; protein Wnt-10a [KO:K01357]
121345445  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
121331917  protein Wnt-11b-like [KO:K01384]
121344813  WNT16; protein Wnt-16 [KO:K01558]
121335505  FZD7; frizzled-7 [KO:K02432]
121338137  FZD1; frizzled-1 [KO:K02432]
121332993  FZD2; frizzled-2 [KO:K02235]
121337196  frizzled-3 [KO:K02329]
121340961  FZD4; frizzled-4 [KO:K02354]
121335337  FZD5; frizzled-5 [KO:K02375]
121338107  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
121340274  FZD6; frizzled-6 [KO:K02376]
121346858  FZD9; frizzled-9 [KO:K02842]
121338877  FZD10; frizzled-10 [KO:K02842]
121332781  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
121344842  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
121336635  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121343969  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121339328  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
121340076  tumor necrosis factor-like [KO:K03156]
121339307  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121346776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121341561  INS; insulin [KO:K04526]
121332824  IGF1; insulin-like growth factor I [KO:K05459]
121341361  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121343296  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121338247  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121335781  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121338675  SOS2; son of sevenless homolog 2 [KO:K03099]
121344866  HRAS; GTPase HRas [KO:K02833]
121332765  KRAS; GTPase KRas [KO:K07827]
121345673  NRAS; GTPase NRas [KO:K07828]
121332742  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121348231  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121343563  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121346775  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121339021  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121333423  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121342944  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121331724  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
121332585  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
121341146  IRS1; insulin receptor substrate 1 [KO:K16172]
121344995  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121341222  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121341824  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121336528  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121342130  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121343951  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121336046  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121334611  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121335752  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121332631  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121336198  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121337030  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
121331518  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
121332845  PRR5; proline-rich protein 5 [KO:K20411]
121344870  PRR5L; proline-rich protein 5-like [KO:K20411]
121347139  RHOA; transforming protein RhoA [KO:K04513]
121338479  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121334557  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121346155  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
otc00561  Glycerolipid metabolism
otc04010  MAPK signaling pathway
otc04140  Autophagy - animal
otc04810  Regulation of actin cytoskeleton
otc04910  Insulin signaling pathway
KO pathway
ko04150   
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