KEGG   PATHWAY: rphi00600
Entry
rphi00600                   Pathway                                
Name
Sphingolipid metabolism - Ruditapes philippinarum (Manila clam)
Class
Metabolism; Lipid metabolism
Pathway map
rphi00600  Sphingolipid metabolism
rphi00600

Module
rphi_M00094  Ceramide biosynthesis [PATH:rphi00600]
rphi_M00099  Sphingosine biosynthesis [PATH:rphi00600]
rphi_M00100  Sphingosine degradation [PATH:rphi00600]
Other DBs
GO: 0006665
Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132735295  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
132722418  serine palmitoyltransferase 2-like isoform X1 [KO:K00654] [EC:2.3.1.50]
132731059  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
132731244  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
132739554  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
132756849  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
132756850  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
132737970  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
132752532  ceramide synthase 2-like isoform X1 [KO:K24621] [EC:2.3.1.297]
132728528  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
132728529  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
132728532  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
132749128  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
132751841  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
132752481  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
132740486  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
132732908  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
132721327  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
132721328  acid ceramidase-like isoform X1 [KO:K12348] [EC:3.5.1.23]
132714046  uncharacterized protein LOC132714046 [KO:K12349] [EC:3.5.1.23]
132715192  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
132755336  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
132724698  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
132724700  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
132724704  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
132754248  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
132750928  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
132743926  sphingomyelin phosphodiesterase 4-like [KO:K12353] [EC:3.1.4.12]
132725323  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
132729855  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
132733360  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
132733364  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
132734174  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
132734296  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
132749210  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
132749211  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
132752201  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
132738674  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
132738675  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
132752558  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132754880  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132754881  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132728645  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132715247  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132715248  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
132760425  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
132720661  sphingosine-1-phosphate phosphatase 2-like [KO:K04716] [EC:3.1.3.-]
132737638  sphingosine-1-phosphate phosphatase 2-like [KO:K04716] [EC:3.1.3.-]
132744223  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
132729245  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
132758356  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
132718310  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
132731289  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
132733709  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
132756223  sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]
132732755  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
132739590  ceramide glucosyltransferase-B-like [KO:K00720] [EC:2.4.1.80]
132754789  ceramide glucosyltransferase-like isoform X1 [KO:K00720] [EC:2.4.1.80]
132753612  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
132727663  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
132727905  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
132725698  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
132730266  beta-galactosidase-like isoform X1 [KO:K12309] [EC:3.2.1.23]
132726947  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
132713294  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
132728892  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
132732408  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
132747613  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132747978  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132723157  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132752154  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132752856  galactose-3-O-sulfotransferase 2-like isoform X1 [KO:K01019] [EC:2.8.2.11]
132742072  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132743323  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132757840  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132729939  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132744106  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132744109  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132744111  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132744112  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132758510  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132732912  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
132718606  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
132731919  alpha-galactosidase A-like isoform X1 [KO:K01189] [EC:3.2.1.22]
132721411  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
132721412  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
132750412  uncharacterized protein LOC132750412 isoform X1 [KO:K12373] [EC:3.2.1.52]
132746686  LOW QUALITY PROTEIN: beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
132734414  ganglioside GM2 activator-like [KO:K12383]
132748472  ganglioside GM2 activator-like [KO:K12383]
132749253  uncharacterized protein LOC132749253 [KO:K12383]
132724529  uncharacterized protein LOC132724529 [KO:K12383]
132724650  uncharacterized protein LOC132724650 [KO:K12383]
132724651  uncharacterized protein LOC132724651 [KO:K12383]
132739746  ganglioside GM2 activator-like isoform X1 [KO:K12383]
132739761  ganglioside GM2 activator-like [KO:K12383]
132754451  ganglioside GM2 activator-like [KO:K12383]
132754452  ganglioside GM2 activator-like isoform X1 [KO:K12383]
132754454  ganglioside GM2 activator-like [KO:K12383]
132756735  ganglioside GM2 activator-like [KO:K12383]
132756736  ganglioside GM2 activator-like [KO:K12383]
132756737  ganglioside GM2 activator-like [KO:K12383]
132756738  ganglioside GM2 activator-like [KO:K12383]
132757655  ganglioside GM2 activator-like [KO:K12383]
132757659  ganglioside GM2 activator-like [KO:K12383]
132758960  uncharacterized protein LOC132758960 [KO:K12383]
132758961  uncharacterized protein LOC132758961 [KO:K12383]
132717314  ganglioside GM2 activator-like [KO:K12383]
132745953  ganglioside GM2 activator-like isoform X1 [KO:K12383]
132760259  uncharacterized protein LOC132760259 [KO:K12383]
132732306  uncharacterized protein LOC132732306 [KO:K12383]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
rphi00260  Glycine, serine and threonine metabolism
rphi00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rphi00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rphi00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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