KEGG   PATHWAY: slal04150
Entry
slal04150                   Pathway                                
Name
mTOR signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
slal04150  mTOR signaling pathway
slal04150

Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111658761  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
111670785  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
111656005  4F2 cell-surface antigen heavy chain-like isoform X1 [KO:K06519]
111653463  slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
111652967  4F2 cell-surface antigen heavy chain-like [KO:K06519]
111659644  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
111666254  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
111662977  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
111664453  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
111672984  V-type proton ATPase subunit B, brain isoform [KO:K02147]
111659396  V-type proton ATPase subunit C 1-A-like [KO:K02148]
111645523  V-type proton ATPase subunit C 1-B-like [KO:K02148]
111658138  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
111661487  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
111671739  V-type proton ATPase subunit E 1-like [KO:K02150]
111666081  V-type proton ATPase subunit E 1-like [KO:K02150]
111656494  V-type proton ATPase subunit E 1-like [KO:K02150]
111670431  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
111651802  V-type proton ATPase subunit G 1-like [KO:K02152]
111657006  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
111655304  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
111649596  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
111645476  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
111670432  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
111672838  ragulator complex protein LAMTOR4-like [KO:K20399]
111670589  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
111669934  flcn; folliculin isoform X1 [KO:K09594]
111657381  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
111654033  ras-related GTP-binding protein A [KO:K16185]
111661613  rragc; ras-related GTP-binding protein C [KO:K16186]
111645537  ras-related GTP-binding protein D-like [KO:K16186]
111671813  ras-related GTP-binding protein C-like [KO:K16186]
111659265  sestrin-2-like isoform X1 [KO:K20394]
111663069  cytosolic arginine sensor for mTORC1 subunit 1-like [KO:K23080]
111673243  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
111644530  mios; GATOR complex protein MIOS [KO:K20407]
111664189  seh1l; nucleoporin SEH1 [KO:K14299]
111658677  wdr24; GATOR complex protein WDR24 [KO:K20408]
111656722  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
111644265  sec13; protein SEC13 homolog [KO:K14004]
111648345  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
111653830  nprl2; GATOR complex protein NPRL2 [KO:K20405]
111660554  nprl3; GATOR complex protein NPRL3 [KO:K20406]
111648076  skp2; S-phase kinase-associated protein 2 [KO:K03875]
111645793  rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
111655458  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111660518  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
111656119  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111664933  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
111649275  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
111672049  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
111658623  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
111655251  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
111666004  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
111658232  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
111671450  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
111655936  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
111657010  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
111667792  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
111659124  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
111656605  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
111672594  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
111645045  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
111655639  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
111665475  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
111652867  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
111658248  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
111654676  eukaryotic translation initiation factor 4E-like [KO:K03259]
111648156  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
111654800  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111670223  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
111673611  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
111654555  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
111663925  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111673584  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
111667836  eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111664076  rps6; 40S ribosomal protein S6 [KO:K02991]
111660538  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
111656801  STE20-related kinase adapter protein beta-like [KO:K17532]
111646019  STE20-related kinase adapter protein beta-like isoform X1 [KO:K17532]
111652612  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
111668885  cab39; calcium-binding protein 39 [KO:K08272]
111665315  calcium-binding protein 39-like [KO:K08272]
111646471  calcium-binding protein 39-like [KO:K08272]
111649950  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
111668062  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
111650122  tsc1; hamartin [KO:K07206]
111646396  hamartin-like isoform X1 [KO:K07206]
111666666  tsc2; tuberin isoform X1 [KO:K07207]
111659043  tuberin-like [KO:K07207]
111671742  TBC1 domain family member 7-like [KO:K20396]
111655861  rheb; GTP-binding protein Rheb [KO:K07208]
111667847  GTP-binding protein Rheb-like [KO:K07208]
111660216  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
111668938  wnt1; proto-oncogene Wnt-1 [KO:K03209]
111669668  protein Wnt-2b-A-like [KO:K00182]
111669004  wnt2b; protein Wnt-2b [KO:K00182]
111672160  wnt2; protein Wnt-2 [KO:K00182]
111653256  wnt3a; protein Wnt-3a [KO:K00312]
111655396  proto-oncogene Wnt-3 [KO:K00312]
111668597  wnt4; protein Wnt-4 [KO:K00408]
111669912  protein Wnt-4-like [KO:K00408]
111663673  protein Wnt-5b isoform X1 [KO:K00444]
111669056  protein Wnt-5a-like [KO:K00444]
111668743  wnt6; protein Wnt-6 [KO:K00445]
111668572  protein Wnt-7a-like [KO:K00572]
111650332  protein Wnt-7b isoform X1 [KO:K00572]
111651962  protein Wnt-7b-like isoform X1 [KO:K00572]
111672186  protein Wnt-7a [KO:K00572]
111670032  protein Wnt-8b [KO:K00714]
111664631  protein Wnt-8-like [KO:K00714]
111664670  protein Wnt-8a-like [KO:K00714]
111653285  wnt9a; protein Wnt-9a [KO:K01064]
111660446  protein Wnt-9b-like [KO:K01064]
111668742  wnt10a; protein Wnt-10a [KO:K01357]
111669053  wnt10b; protein Wnt-10b [KO:K01357]
111663496  wnt11; protein Wnt-11 [KO:K01384]
111647701  wnt16; protein Wnt-16 [KO:K01558]
111646694  frizzled-1-like [KO:K02432]
111652398  frizzled-7-like [KO:K02432]
111646854  frizzled-7-A-like [KO:K02432]
111660634  fzd2; frizzled-2 [KO:K02235]
111668153  uncharacterized protein LOC111668153 isoform X1 [KO:K02235]
111672626  fzd3; frizzled-3 [KO:K02329]
111668834  frizzled-3-like [KO:K02329]
111655295  fzd4; frizzled-4 [KO:K02354]
111659827  fzd8; frizzled-8 [KO:K02375]
111673168  frizzled-5-like [KO:K02375]
111668374  frizzled-8-like [KO:K02375]
111658091  fzd6; frizzled-6 [KO:K02376]
111649978  fzd9; frizzled-9 [KO:K02842]
111644898  fzd10; frizzled-10 [KO:K02842]
111647712  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
111671053  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
111671096  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
111663351  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
111665759  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
111654183  dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111662131  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111645657  tumor necrosis factor-like [KO:K03156]
111655660  tumor necrosis factor-like isoform X1 [KO:K03156]
111669911  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
111666877  uncharacterized protein LOC111666877 [KO:K03158]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111653396  ins; insulin [KO:K04526]
111672131  insulin-like [KO:K04526]
111664630  insulin-like [KO:K04526]
111664700  igf1; insulin-like growth factor I [KO:K05459]
111658878  insulin-like growth factor I [KO:K05459]
111669127  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111650192  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111672288  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111653328  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111673746  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111653428  sos1; son of sevenless homolog 1 [KO:K03099]
111665903  sos2; son of sevenless homolog 2 [KO:K03099]
111661823  hras; GTPase HRas [KO:K02833]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111664218  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111652614  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111645936  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
111649832  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111646474  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111647316  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
111665735  insulin receptor substrate 1-B-like [KO:K16172]
111651451  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111671089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111670553  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111671597  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111649932  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111666834  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111661265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111670636  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111671654  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111673607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111668884  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111670050  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111655103  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111658643  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111655428  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111658207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111648123  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
111644972  rapamycin-insensitive companion of mTOR-like [KO:K08267]
111648102  rictor; rapamycin-insensitive companion of mTOR [KO:K08267]
111663670  proline-rich protein 5-like isoform X1 [KO:K20411]
111671227  proline-rich protein 5-like [KO:K20411]
111649044  prr5l; proline-rich protein 5-like [KO:K20411]
111669019  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111666387  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111660814  transforming protein RhoA [KO:K04513]
111658866  rho-related GTP-binding protein RhoA-C [KO:K04513]
111659692  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111667575  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
111647517  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
111663270  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
111669824  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
111650865  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
111655039  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
111651204  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
slal00561  Glycerolipid metabolism
slal04010  MAPK signaling pathway
slal04140  Autophagy - animal
slal04810  Regulation of actin cytoskeleton
slal04910  Insulin signaling pathway
KO pathway
ko04150   
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