KEGG   COMPOUND: C00073
Entry
C00073                      Compound                               
Name
L-Methionine;
Methionine;
L-2-Amino-4methylthiobutyric acid
Formula
C5H11NO2S
Exact mass
149.051
Mol weight
149.2113
Structure
Remark
Same as: D00019
Reaction
R00177 R00648 R00649 R00650 R00651 R00652 R00653 R00654
R00655 R00656 R00657 R00946 R01078 R02025 R02821 R03472
R03659 R04153 R04405 R04710 R06268 R06269 R06270 R06895
R07396 R07606 R07608 R07767 R08583 R08588 R08618 R08635
R08862 R08873 R08875 R08893 R09373 R09394 R09637 R09639
R10204 R10220 R10246 R10430 R10437 R10552 R10645 R10646
R10649 R10650 R10652 R10667 R11063 R11112 R11274 R11275
R11293 R11294 R11484 R11700 R11710 R11919 R12002 R12055
R12098 R12161 R12162 R12238 R12239 R12423 R12424 R12497
R12507 R12569 R12724 R12750 R12788 R13130 R13131 R13180
Pathway
map00270  Cysteine and methionine metabolism
map00470  D-Amino acid metabolism
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map00999  Biosynthesis of various plant secondary metabolites
map01060  Biosynthesis of plant secondary metabolites
map01070  Biosynthesis of plant hormones
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map01523  Antifolate resistance
map04148  Efferocytosis
map04974  Protein digestion and absorption
map04978  Mineral absorption
map04980  Cobalamin transport and metabolism
map05230  Central carbon metabolism in cancer
Module
M00017  Methionine biosynthesis, aspartate => homoserine => methionine
M00034  Methionine salvage pathway
M00035  Methionine degradation
M00368  Ethylene biosynthesis, methionine => ethylene
M00609  Cysteine biosynthesis, methionine => cysteine
M00953  Mugineic acid biosynthesis, methionine => 3-epihydroxymugineic acid
Network
nt06030  Methionine metabolism
Enzyme
1.1.98.7        1.1.99.38       1.3.98.3        1.3.98.6        
1.3.98.7        1.4.3.2         1.8.4.11        1.8.4.13        
1.8.4.14        1.17.98.2       1.21.98.1       1.21.98.3       
1.21.98.5       1.97.1.4        2.1.1.3         2.1.1.5         
2.1.1.10        2.1.1.12        2.1.1.13        2.1.1.14        
2.1.1.280       2.1.1.308       2.1.1.326       2.1.1.342       
2.1.1.350       2.1.1.379       2.1.1.390       2.1.1.-         
2.4.99.17       2.5.1.6         2.5.1.49        2.5.1.63        
2.5.1.94        2.5.1.120       2.5.1.147       2.6.1.5         
2.6.1.57        2.6.1.73        2.6.1.88        2.6.1.117       
2.6.1.-         2.8.1.6         2.8.1.8         2.8.4.3         
2.8.4.4         2.8.4.5         3.4.13.12       3.5.1.31        
3.13.2.3        4.1.1.57        4.1.3.44        4.1.99.17       
4.1.99.19       4.1.99.22       4.1.99.23       4.1.99.26       
4.3.1.30        4.3.1.32        4.4.1.11        4.7.1.1         
5.1.1.2         6.1.1.10
 » show all
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00073  Methionine (Met)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB26 Methionine
      D00019  Methionine (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Methionine
    D00019  Methionine (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00019  L-Methionine
Other DBs
CAS: 63-68-3
PubChem: 3373
ChEBI: 16643
KNApSAcK: C00001379
PDB-CCD: MET[PDBj]
3DMET: B01148
NIKKAJI: J9.174J
LinkDB
KCF data

ATOM        9
            1   C1c C    24.5047  -19.4197
            2   C6a C    23.3598  -18.6719
            3   C1b C    25.7313  -18.7361
            4   N1a N    24.5455  -20.8273
            5   O6a O    22.1332  -19.3553
            6   O6a O    23.3772  -17.2641
            7   C1b C    26.9405  -19.4546
            8   S2a S    28.1672  -18.7712
            9   C1a C    29.3647  -19.4896
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     7   8 1
            8     8   9 1

» Japanese version

KEGG   COMPOUND: C00101
Entry
C00101                      Compound                               
Name
Tetrahydrofolate;
5,6,7,8-Tetrahydrofolate;
Tetrahydrofolic acid;
THF;
(6S)-Tetrahydrofolate;
(6S)-Tetrahydrofolic acid;
(6S)-THFA
Formula
C19H23N7O6
Exact mass
445.171
Mol weight
445.4292
Structure
Reaction
R00611 R00936 R00937 R00939 R00940 R00941 R00942 R00943
R00944 R00945 R00946 R01221 R01225 R01226 R01564 R01565
R01669 R02287 R02289 R02573 R02729 R02912 R03189 R03704
R03940 R04125 R04242 R04325 R04326 R04560 R06613 R07660
R08701 R09093 R09270 R09271 R10136 R10243 R10333 R11955
R11956 R12548 R12790 R12967
Pathway
map00260  Glycine, serine and threonine metabolism
map00670  One carbon pool by folate
map00680  Methane metabolism
map00720  Carbon fixation pathways in prokaryotes
map00785  Lipoic acid metabolism
map00790  Folate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01240  Biosynthesis of cofactors
map01523  Antifolate resistance
map04980  Cobalamin transport and metabolism
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00140  C1-unit interconversion, prokaryotes
M00141  C1-unit interconversion, eukaryotes
M00377  Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
M00621  Glycine cleavage system
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Network
nt06030  Methionine metabolism
nt06033  Glycine, serine and arginine metabolism
nt06037  Histidine metabolism
Enzyme
1.4.1.27        1.5.1.3         1.5.1.6         1.5.3.10        
1.5.3.24        1.5.8.3         1.5.8.4         2.1.1.13        
2.1.1.19        2.1.1.74        2.1.1.148       2.1.1.258       
2.1.1.269       2.1.1.341       2.1.1.378       2.1.1.385       
2.1.1.389       2.1.1.-         2.1.2.1         2.1.2.2         
2.1.2.3         2.1.2.4         2.1.2.5         2.1.2.7         
2.1.2.8         2.1.2.9         2.1.2.10        2.1.2.11        
2.1.2.13        2.1.2.14        2.1.5.1         2.3.1.169       
3.4.19.9        3.5.1.10        6.3.2.17        6.3.4.3
Brite
Compounds with biological roles [BR:br08001]
 Vitamins and cofactors
  Cofactors
   Coenzymes
    C00101  THF
Other DBs
CAS: 135-16-0
PubChem: 3401
ChEBI: 15635 20506
KNApSAcK: C00007249
PDB-CCD: THG[PDBj]
3DMET: B04633
NIKKAJI: J184.393A
LinkDB
KCF data

ATOM        32
            1   N4x N     9.5392  -17.5978
            2   C8y C     9.5392  -19.0001
            3   N5x N    10.7312  -19.7013
            4   C8y C    11.9933  -19.0001
            5   C8y C    11.9933  -17.5978
            6   C8y C    10.7312  -16.8966
            7   N1x N    13.1853  -19.7013
            8   C1x C    14.3773  -19.0001
            9   C1y C    14.3773  -17.5978
            10  N1x N    13.1853  -16.8966
            11  O5x O    10.7312  -15.4943
            12  N1a N     8.3219  -19.6964
            13  C1b C    15.5918  -16.8966
            14  N1b N    16.8063  -17.5978
            15  C8y C    18.0207  -16.8966
            16  C8x C    19.2373  -17.5990
            17  C8x C    20.4517  -16.8978
            18  C8y C    20.4517  -15.4955
            19  C8x C    19.2352  -14.7931
            20  C8x C    18.0207  -15.4943
            21  C5a C    21.6920  -14.7931
            22  N1b N    22.9065  -15.4943
            23  O5a O    21.6979  -13.3911
            24  C1c C    24.1397  -14.7821
            25  C1b C    25.3469  -15.4790
            26  C1b C    26.5312  -14.7950
            27  C6a C    27.7272  -15.4855
            28  O6a O    28.9171  -14.7983
            29  O6a O    27.7274  -16.8963
            30  C6a C    24.1394  -13.3909
            31  O6a O    22.9130  -12.6830
            32  O6a O    25.3419  -12.6962
BOND        34
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    6  11 2
            13    2  12 1
            14    9  13 1 #Up
            15   13  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   21  22 1
            25   21  23 2
            26   22  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   27  29 2
            32   24  30 1 #Down
            33   30  31 2
            34   30  32 1

» Japanese version

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