KEGG   PATHWAY: cclu04150
Entry
cclu04150                   Pathway                                
Name
mTOR signaling pathway - Coregonus clupeaformis (lake whitefish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cclu04150  mTOR signaling pathway
cclu04150

Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121538279  large neutral amino acids transporter small subunit 1-like [KO:K13780]
121531773  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
121576738  large neutral amino acids transporter small subunit 1 [KO:K13780]
121545953  large neutral amino acids transporter small subunit 1-like [KO:K13780]
121579477  4F2 cell-surface antigen heavy chain [KO:K06519]
121541825  4F2 cell-surface antigen heavy chain [KO:K06519]
121558220  4F2 cell-surface antigen heavy chain [KO:K06519]
121567054  si:dkey-202g17.3; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
121581977  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
121549827  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121541934  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
121569267  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121579570  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
121541549  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
121553239  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
121570116  V-type proton ATPase subunit B, brain isoform [KO:K02147]
121586225  V-type proton ATPase subunit C 1-A [KO:K02148]
121548497  V-type proton ATPase subunit D [KO:K02149]
121552901  V-type proton ATPase subunit D [KO:K02149]
121555284  V-type proton ATPase subunit E 1-like [KO:K02150]
121532303  V-type proton ATPase subunit E 1 [KO:K02150]
121543527  V-type proton ATPase subunit E 1 [KO:K02150]
121546284  V-type proton ATPase subunit F [KO:K02151]
121543710  V-type proton ATPase subunit F [KO:K02151]
121583346  V-type proton ATPase subunit G 1 [KO:K02152]
121541569  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
121580515  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
121583135  ragulator complex protein LAMTOR1-like [KO:K20397]
121531279  ragulator complex protein LAMTOR1-like [KO:K20397]
121541593  ragulator complex protein LAMTOR1 [KO:K20397]
121566804  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
121567816  ragulator complex protein LAMTOR1 [KO:K20397]
121577891  ragulator complex protein LAMTOR1-like [KO:K20397]
121543101  lamtor2; LOW QUALITY PROTEIN: ragulator complex protein LAMTOR2 [KO:K20398]
121544793  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
121546283  ragulator complex protein LAMTOR4 [KO:K20399]
121543711  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
121546124  ragulator complex protein LAMTOR5-like [KO:K16344]
121537708  ragulator complex protein LAMTOR5 [KO:K16344]
121556505  folliculin-like [KO:K09594]
121542918  folliculin [KO:K09594]
121574011  LOW QUALITY PROTEIN: folliculin-interacting protein 1 [KO:K20400]
121579231  folliculin-interacting protein 1-like [KO:K20400]
121573706  rraga; ras-related GTP-binding protein A [KO:K16185]
121571859  ras-related GTP-binding protein C [KO:K16186]
121557214  ras-related GTP-binding protein C [KO:K16186]
121557733  ras-related GTP-binding protein C [KO:K16186]
121539585  rragd; ras-related GTP-binding protein D [KO:K16186]
121586609  sesn2; sestrin-2 isoform X1 [KO:K20394]
121585215  castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
121530775  cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
121537597  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
121579274  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
123480963  GATOR complex protein MIOS isoform X1 [KO:K20407]
121543079  GATOR complex protein MIOS isoform X1 [KO:K20407]
121575671  nucleoporin SEH1 isoform X1 [KO:K14299]
121559468  nucleoporin SEH1 [KO:K14299]
121547215  GATOR complex protein WDR24-like [KO:K20408]
121567467  wdr24; GATOR complex protein WDR24 [KO:K20408]
121574716  protein SEC13 homolog [KO:K14004]
121577928  protein SEC13 homolog [KO:K14004]
121582417  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
121574855  nprl2; GATOR complex protein NPRL2 [KO:K20405]
121578414  GATOR complex protein NPRL2-like [KO:K20405]
121569101  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
121550956  LOW QUALITY PROTEIN: GATOR complex protein NPRL3-like [KO:K20406]
121582186  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
121573859  S-phase kinase-associated protein 2 [KO:K03875]
121581508  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
121549964  E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
121535241  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
121569824  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
121534011  regulatory-associated protein of mTOR [KO:K07204]
121533261  regulatory-associated protein of mTOR-like [KO:K07204]
121568930  uncharacterized protein LOC121568930 [KO:K16184]
121568968  uncharacterized protein LOC121568968 [KO:K16184]
121537247  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121586071  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
121578248  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
121542746  DEP domain-containing mTOR-interacting protein [KO:K20402]
121547504  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
121547207  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
121545599  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
121584868  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
121582759  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
121530926  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
121574132  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
121571880  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
121586245  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
121586598  growth factor receptor-bound protein 10 [KO:K20064]
121570069  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
121539382  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
121550018  phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
121575528  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
121551560  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
121545065  phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
121569884  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
121582574  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121541619  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121550251  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
121558212  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121567759  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
121584889  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
121583488  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
121530955  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
121541630  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121546252  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
121539420  eukaryotic translation initiation factor 4E-1A [KO:K03259]
121556907  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
121581230  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
121541250  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
121574652  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
121544339  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
121553400  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
121557773  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
121579764  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121559072  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
121573561  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121568011  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
121559390  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
121575537  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121578024  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121537813  eukaryotic translation initiation factor 4B [KO:K03258]
121545925  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121562225  rps6; 40S ribosomal protein S6 [KO:K02991]
123491195  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
121568896  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
121560067  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
121581209  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
121533554  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
121535482  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121576759  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
121558683  cab39l; calcium-binding protein 39-like [KO:K08272]
121566903  calcium-binding protein 39 [KO:K08272]
121567693  calcium-binding protein 39-like [KO:K08272]
121545105  calcium-binding protein 39 [KO:K08272]
121587300  calcium-binding protein 39 [KO:K08272]
121582705  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121540184  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121533332  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121541495  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
121582456  hamartin-like [KO:K07206]
121584591  tsc1a; TSC complex subunit 1a [KO:K07206]
121541720  hamartin isoform X1 [KO:K07206]
121533065  tsc2; tuberin [KO:K07207]
121540481  tbc1d7; TBC1 domain family member 7 [KO:K20396]
121581395  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
121549657  GTP-binding protein Rheb isoform X1 [KO:K07208]
121575255  GTP-binding protein Rheb-like [KO:K07208]
121535701  GTP-binding protein Rheb [KO:K07208]
121569183  GTP-binding protein Rheb isoform X1 [KO:K07208]
121577614  GTP-binding protein Rheb [KO:K07208]
121530807  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
121553283  DNA damage-inducible transcript 4 protein-like [KO:K08270]
121546749  wnt1; protein Wnt-1 [KO:K03209]
121537401  protein Wnt-1-like [KO:K03209]
121531255  protein Wnt-2-like [KO:K00182]
121531682  protein Wnt-2 [KO:K00182]
121574897  protein Wnt-2b-A-like [KO:K00182]
121578373  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
121582184  proto-oncogene Wnt-3-like [KO:K00312]
121547287  proto-oncogene Wnt-3 [KO:K00312]
121581538  protein Wnt-3a [KO:K00312]
121534656  protein Wnt-3a [KO:K00312]
121575947  protein Wnt-4a [KO:K00408]
121578544  protein Wnt-4a-like [KO:K00408]
121543006  protein Wnt-4-like [KO:K00408]
121586202  protein Wnt-4-like [KO:K00408]
121538632  protein Wnt-5a-like [KO:K00444]
121553644  wnt5b; protein Wnt-5b [KO:K00444]
121546086  wnt5a; protein Wnt-5a [KO:K00444]
121569974  LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
121551654  protein Wnt-6-like [KO:K00445]
121536676  protein Wnt-6 [KO:K00445]
121538568  protein Wnt-7a [KO:K00572]
121555060  protein Wnt-7b-like [KO:K00572]
121531725  protein Wnt-7b [KO:K00572]
121540600  protein Wnt-7b isoform X1 [KO:K00572]
121545399  protein Wnt-7a [KO:K00572]
121578504  protein Wnt-7a-like [KO:K00572]
121581585  protein Wnt-7b-like [KO:K00572]
121583902  protein Wnt-8b [KO:K00714]
121553552  protein Wnt-8b-like [KO:K00714]
121545985  protein Wnt-8-like [KO:K00714]
121545996  protein Wnt-8a-like [KO:K00714]
121581047  protein Wnt-9a [KO:K01064]
121551096  protein Wnt-9b-like [KO:K01064]
121535361  protein Wnt-9a-like [KO:K01064]
121569555  protein Wnt-9b [KO:K01064]
121551662  protein Wnt-10a [KO:K01357]
121536229  protein Wnt-10a-like [KO:K01357]
121537402  protein Wnt-10b-like [KO:K01357]
121545857  protein Wnt-10b-like [KO:K01357]
121579778  protein Wnt-11-like isoform X1 [KO:K01384]
121580351  protein Wnt-11-like [KO:K01384]
121573581  protein Wnt-11 [KO:K01384]
121574367  protein Wnt-11-like [KO:K01384]
121542307  protein Wnt-16-like [KO:K01558]
121576069  protein Wnt-16 [KO:K01558]
121555147  frizzled-7-A [KO:K02432]
121540884  frizzled-7-A-like [KO:K02432]
121543022  frizzled-1-like [KO:K02432]
121585441  frizzled-1-like [KO:K02432]
123492920  LOW QUALITY PROTEIN: frizzled-1-like [KO:K02432]
121550560  frizzled-2 [KO:K02235]
121539133  frizzled-3-like [KO:K02329]
121548620  frizzled-3-like [KO:K02329]
121552568  frizzled-3-like [KO:K02329]
121545060  frizzled-3-like isoform X1 [KO:K02329]
121566814  frizzled-4-like [KO:K02354]
121567806  frizzled-4 [KO:K02354]
121582928  frizzled-5-like [KO:K02375]
121555181  frizzled-5-like [KO:K02375]
121580873  frizzled-8-like [KO:K02375]
121549942  frizzled-8 [KO:K02375]
121535165  frizzled-8-like [KO:K02375]
121537062  frizzled-5-like [KO:K02375]
121543044  LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
123487200  LOW QUALITY PROTEIN: frizzled-6-like [KO:K02376]
121585996  frizzled-6 [KO:K02376]
121584780  frizzled-10 [KO:K02842]
121579345  frizzled-9 [KO:K02842]
121573920  frizzled-9-like [KO:K02842]
121564545  frizzled-9 [KO:K02842]
121550692  frizzled-10-like [KO:K02842]
121567544  frizzled-9-like [KO:K02842]
121531755  low-density lipoprotein receptor-related protein 5-like isoform X2 [KO:K03068]
121576749  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
121563376  lrp6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
121559280  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6-like [KO:K03068]
121538503  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121579726  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
121580787  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
121567306  segment polarity protein dishevelled homolog DVL-3-like isoform X4 [KO:K02353]
121535071  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
121554282  dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
121572109  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
121545653  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
121561687  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
121571637  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121537086  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121554634  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121585680  tumor necrosis factor-like [KO:K03156]
121585681  tumor necrosis factor-like [KO:K03156]
121573010  tumor necrosis factor-like [KO:K03156]
121566279  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
121542980  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121586213  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121573284  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121580143  insulin-like [KO:K04526]
121533215  insulin-like [KO:K04526]
121574459  insulin [KO:K04526]
121548967  insulin-like growth factor I isoform X1 [KO:K05459]
121578998  insulin-like growth factor I isoform X1 [KO:K05459]
121540392  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
121534131  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
121535412  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
121581272  LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
121555650  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
121531890  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121576630  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
121568978  LOW QUALITY PROTEIN: growth factor receptor-bound protein 2 [KO:K04364]
121554074  growth factor receptor-bound protein 2 [KO:K04364]
123481432  growth factor receptor-bound protein 2-like [KO:K04364]
123491201  growth factor receptor-bound protein 2-like [KO:K04364]
121539095  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121544586  son of sevenless homolog 2-like isoform X1 [KO:K03099]
121572356  son of sevenless homolog 1-like isoform X1 [KO:K03099]
123481437  son of sevenless homolog 1-like isoform X1 [KO:K03099]
121532188  GTPase HRas [KO:K02833]
121576390  GTPase HRas [KO:K02833]
121532244  kras; GTPase KRas isoform X1 [KO:K07827]
121551578  GTPase HRas [KO:K07827]
121577009  GTPase KRas isoform X1 [KO:K07827]
123482642  GTPase HRas-like [KO:K07827]
123480947  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
121556391  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
121538562  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121545408  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121540361  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121533527  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121535511  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121581348  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121584339  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123491220  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121550334  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121579558  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
121539004  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121547686  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
121549804  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121541924  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121575290  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
121569292  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121545132  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121559819  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
121561393  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
121579823  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
121573626  insulin receptor substrate 1-B-like [KO:K16172]
121567271  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
121554386  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
121572107  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
121584610  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121582619  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
121581087  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121540427  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121533661  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121541581  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121534059  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121535055  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121535583  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121576870  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121580765  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121538393  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121580697  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121533376  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121566901  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121534970  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121567694  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121557873  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121547337  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121533385  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X5 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121553788  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121570941  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121547217  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
121567611  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
121569118  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121551130  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121579671  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121539230  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121547648  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121533168  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121566954  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121541975  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121567780  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121552196  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121544961  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123481415  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121548848  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121547254  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121542592  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
121568297  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121581930  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
121585083  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
121581857  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
121573860  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
121582187  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
121531371  prr5l; proline-rich protein 5-like [KO:K20411]
121532182  proline-rich protein 5-like isoform X1 [KO:K20411]
121576384  proline-rich protein 5 isoform X1 [KO:K20411]
123490386  proline-rich protein 5-like [KO:K20411]
121584334  proline-rich protein 5 isoform X1 [KO:K20411]
121538399  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
121575450  transforming protein RhoA-like [KO:K04513]
121578110  transforming protein RhoA-like [KO:K04513]
121537342  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
121545495  rho-related GTP-binding protein RhoA-B [KO:K04513]
121545542  rho-related GTP-binding protein RhoA-C [KO:K04513]
121578369  rho-related GTP-binding protein RhoA-D [KO:K04513]
121538165  rho-related GTP-binding protein RhoA-B [KO:K04513]
121545275  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
121557105  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121533158  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121551465  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
123483290  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
121561893  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
121557030  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121543837  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
121556473  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
121555444  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121571875  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121548479  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121542333  serine/threonine-protein kinase Sgk2-like [KO:K13302] [EC:2.7.11.1]
121542422  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
121586798  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cclu00561  Glycerolipid metabolism
cclu04010  MAPK signaling pathway
cclu04140  Autophagy - animal
cclu04810  Regulation of actin cytoskeleton
cclu04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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