KEGG   PATHWAY: lcat04015
Entry
lcat04015                   Pathway                                
Name
Rap1 signaling pathway - Lemur catta (Ring-tailed lemur)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
lcat04015  Rap1 signaling pathway
lcat04015

Other DBs
GO: 0007264
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123635037  RAP1A; ras-related protein Rap-1A [KO:K04353]
123639540  RAP1B; ras-related protein Rap-1b [KO:K07836]
123629770  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
123647122  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
123647582  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
123645581  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
123632367  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
123639979  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123636893  CALM2; calmodulin-2 [KO:K02183]
123645611  CALM1; calmodulin-1 [KO:K02183]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123623919  CALM3; calmodulin-3 [KO:K02183]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123636681  calmodulin-alpha-like [KO:K02183]
123648568  F2R; proteinase-activated receptor 1 [KO:K03914]
123640004  F2RL3; proteinase-activated receptor 4 [KO:K04236]
123630189  P2RY1; P2Y purinoceptor 1 [KO:K04270]
123624620  FPR1; fMet-Leu-Phe receptor [KO:K04172]
123646547  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
123638322  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123635466  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
123640118  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123625701  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
123650568  ADORA2B; adenosine receptor A2b [KO:K04267]
123622308  neuroendocrine secretory protein 55-like [KO:K04632]
123622310  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123648063  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123636670  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123650680  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123640442  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
123625466  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123644339  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
123632319  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123640470  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
123644044  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123636786  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123641412  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123637917  FGF1; fibroblast growth factor 1 [KO:K18496]
123638827  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123637964  FGF18; fibroblast growth factor 18 [KO:K04358]
123622454  FGF7; fibroblast growth factor 7 [KO:K04358]
123632208  FGF22; fibroblast growth factor 22 [KO:K04358]
123640719  FGF6; fibroblast growth factor 6 [KO:K04358]
123648417  FGF10; fibroblast growth factor 10 [KO:K04358]
123649197  FGF9; fibroblast growth factor 9 [KO:K04358]
123641892  FGF4; fibroblast growth factor 4 [KO:K04358]
123626358  FGF20; fibroblast growth factor 20 [KO:K04358]
123626704  FGF17; fibroblast growth factor 17 [KO:K04358]
123642170  FGF3; fibroblast growth factor 3 [KO:K04358]
123650103  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123627370  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
123642172  FGF19; fibroblast growth factor 19 [KO:K22603]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123640148  FGF23; fibroblast growth factor 23 [KO:K22428]
123635087  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
123642915  INS; insulin [KO:K04526]
123639374  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123635010  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123639466  KITLG; kit ligand isoform X1 [KO:K05461]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123646604  PGF; placenta growth factor isoform X1 [KO:K16859]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123644674  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123626572  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123622470  ANGPT4; angiopoietin-4 [KO:K05467]
123632816  EFNA2; ephrin-A2 [KO:K05462]
123648052  EFNA5; ephrin-A5 [KO:K05462]
123634049  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123634050  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123634052  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123620742  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
123635850  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123638075  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123624843  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123645784  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123635942  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123626242  CRKL; crk-like protein isoform X1 [KO:K04438]
123620702  CRK; adapter molecule crk isoform X1 [KO:K04438]
123646573  RAPGEF1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277]
123625428  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123625167  CDH1; cadherin-1 [KO:K05689]
123623521  CTNNB1; catenin beta-1 [KO:K02105]
123623594  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123646972  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
123635058  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
123638526  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123638794  rap guanine nucleotide exchange factor 2-like [KO:K08018]
123638804  rap guanine nucleotide exchange factor 2-like [KO:K08018]
123637738  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
123632516  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
123648482  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
123637973  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
123620769  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123636802  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
123623914  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
123650461  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
123641670  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
123632194  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
123623249  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123647150  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123635002  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123625313  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
123635876  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
123647273  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
123641354  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
123627452  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
123624387  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
123622848  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
123621930  THBS1; thrombospondin-1 [KO:K16857]
123646555  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
123647769  RALA; ras-related protein Ral-A [KO:K07834]
123643581  RALB; ras-related protein Ral-B [KO:K07835]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123639294  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123650723  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123626234  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1 [KO:K17704]
123630651  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
123646154  TLN1; talin-1 isoform X1 [KO:K06271]
123621031  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
123620572  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
123621246  PFN1; profilin-1 [KO:K05759]
123630170  PFN2; profilin-2 isoform X1 [KO:K05759]
123623456  PFN3; profilin-3 [KO:K05759]
123636664  PFN4; profilin-4 [KO:K05759]
123623950  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
123627519  ENAH; protein enabled homolog isoform X1 [KO:K05746]
123644594  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
123631525  ACTB; actin, cytoplasmic 1 [KO:K05692]
123650686  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123637906  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123643616  transforming protein RhoA-like [KO:K04513]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123643941  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123645814  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
123634968  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123635877  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123630677  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123626590  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123621670  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
123622725  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
123625220  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
123635996  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
123630254  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
123633458  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
123642713  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
123647309  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
123623458  RGS14; regulator of G-protein signaling 14 [KO:K17706]
123627130  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
123632733  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123632686  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123630775  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123626683  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123650554  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123650624  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123634187  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123650260  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123639921  KRAS; GTPase KRas [KO:K07827]
123635081  NRAS; GTPase NRas [KO:K07828]
123623815  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
lcat04010  MAPK signaling pathway
lcat04014  Ras signaling pathway
lcat04020  Calcium signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04510  Focal adhesion
lcat04520  Adherens junction
lcat04660  T cell receptor signaling pathway
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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