Entry Name Viral replication
Class Genetic Information Processing; Information processing in virusesBRITE hierarchy
Pathway map Ortholog table Drug D00296 Didanosine (JAN/USP/INN)
D00317 Famciclovir (JAN/USP/INN)
D00333 Ganciclovir (JAN/USP/INN)
D00342 Idoxuridine (JP18/USP/INN)
D00353 Lamivudine (JAN/USP/INN)
D00398 Valacyclovir hydrochloride (USP)
D00412 Zalcitabine (JAN/USP/INN)
D00413 Zidovudine (JP18/USP/INN)
D00423 Ribavirin (JP18/USP/INN)
D00435 Nevirapine (JAN/USP/INN)
D00579 Foscarnet sodium (USP/INN)
D00891 Abacavir sulfate (JAN/USP)
D00895 Delavirdine mesylate (USAN)
D00896 Efavirenz (JAN/USP/INN)
D01199 Emtricitabine (JAN/USAN/INN)
D01655 Adefovir dipivoxil (USAN)
D01734 Sorivudine (JAN/USAN/INN)
D01982 Tenofovir disoproxil fumarate (JAN/USAN)
D02124 Penciclovir sodium (USAN)
D02267 Foscarnet sodium hydrate (JAN)
D02297 Emtricitabine and tenofovir disoproxil
D02734 Abacavir succinate (USAN)
D02764 Acyclovir sodium (USAN)
D03001 Atevirdine mesylate (USAN)
D03256 Valganciclovir hydrochloride (JAN/USP)
D03981 Elvucitabine (USAN/INN)
D04112 Etravirine (JAN/USAN/INN)
D04254 Fosfonet sodium (USAN/INN)
D04301 Ganciclovir sodium (USAN)
D05588 Pradefovir mesylate (USAN)
D06275 Valomaciclovir stearate (USAN)
D06278 Valtorcitabine dihydrochloride (USAN)
D06299 Vidarabine phosphate (USAN)
D06300 Vidarabine sodium phosphate (USAN)
D06580 Dexelvucitabine (USAN/INN)
D06651 Taribavirin hydrochloride (USAN)
D06677 Elvitegravir (JAN/USAN)
D07133 Raltegravir potassium (JAN/USAN)
D07507 Zidovudine and lamivudine
D08775 Abacavir sulfate and lamivudine
D09012 Telaprevir (JAN/USAN/INN)
D09028 Valopicitabine dihydrochloride (USAN)
D09537 Favipiravir (JAN/USAN/INN)
D09583 Balapiravir hydrochloride (USAN)
D09720 Rilpivirine (JAN/USAN/INN)
D09885 Danoprevir sodium (USAN)
D09958 Rilpivirine hydrochloride (JAN/USAN)
D09987 Vaniprevir (JAN/USAN/INN)
D10105 Daclatasvir dihydrochloride (USAN)
D10113 Dolutegravir sodium (JAN/USAN)
D10366 Sofosbuvir (JAN/USAN/INN)
D10394 Deldeprevir sodium (USAN)
D10428 Tenofovir alafenamide (USAN/INN)
D10462 Faldaprevir sodium (JAN/USAN)
D10469 Simeprevir sodium (JAN)
D10477 Mericitabine (USAN/INN)
D10518 Valaciclovir hydrochloride hydrate (JAN)
D10548 Cabotegravir (JAN/USAN/INN)
D10549 Cabotegravir sodium (JAN/USAN)
D10571 Rilpivirine hydrochloride, tenofovir disoproxil fumarate and emtricitabine
D10578 Ledipasvir and sofosbuvir
D10580 Paritaprevir (USAN/INN)
D10581 Dasabuvir sodium hydrate
D10582 Dasabuvir, ombitasvir, paritaprevir and ritonavir
D10597 Paritaprevir hydrate (JAN)
D10598 Ombitasvir hydrate (JAN)
D10599 Ledipasvir acetonate (JAN)
D10600 Dolutegravir, abacavir and lamivudine
D10605 Tenofovir alafenamide fumarate (JAN/USAN)
D10611 Beclabuvir hydrochloride (JAN/USAN)
D10622 Deleobuvir sodium (JAN/USAN)
D10624 Doravirine (JAN/USAN/INN)
D10625 Elbasvir (JAN/USAN/INN)
D10632 Filociclovir (USAN/INN)
D10745 Ombitasvir, paritaprevir and ritonavir
D10754 Lamivudine and raltegravir
D10755 Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide
D10756 Elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil
D10778 Elbasvir and grazoprevir
D10806 Velpatasvir (JAN/USAN/INN)
D10815 Glecaprevir hydrate (JAN)
D10816 Pibrentasvir (JAN/USAN/INN)
D10834 Tenofovir disoproxil phosphate
D10835 Emtricitabine and tenofovir alafenamide
D10838 Abacavir, lamivudine and zidovudine
D10851 Efavirenz, emtricitabine and tenofovir disoproxil
D10882 Daclatasvir, asunaprevir and beclabuvir
D10899 Voxilaprevir (USAN/INN)
D10900 Sofosbuvir, velpatasvir and voxilaprevir
D10910 Bictegravir sodium (JAN/USAN)
D10996 Uprifosbuvir (USAN/INN)
D11021 Baloxavir marboxil (JAN/USAN/INN)
D11039 Bictegravir, emtricitabine and tenofovir alafenamide
D11282 Dolutegravir sodium and rilpivirine hydrochloride
D11367 Pimodivir hydrochloride (USAN)
D11382 Darunavir, cobicistat, emtricitabine and tenofovir alafenamide
D11391 Tenofovir disoproxil maleate
D11392 Efavirenz, lamivudine and tenofovir disoproxil fumarate
D11395 Lamivudine and tenofovir disoproxil
D11396 Doravirine, lamivudine and tenofovir disoproxil
D11521 Lamivudine, nevirapine and zidovudine
D11522 Dolutegravir and lamivudine
D11627 Acyclovir and hydrochortisone
D11721 Rovafovir etalafenamide (USAN)
D11722 Rovafovir etalafenamide citrate (USAN)
D11914 Islatravir hydrate (JAN/USAN)
D11966 Cabotegravir and rilpivirine
D12260 Bemnifosbuvir sulfate (USAN)
D12745 Ravidasvir hydrochloride (USAN)
D12812 Pritelivir mesylate (USAN)
Orthology K25235 Simplexvirus DNA primase [EC:2.7.7.-]
K25236 Simplexvirus DNA helicase/primase complex-associated protein
K18964 Herpesviridae DNA polymerase catalytic subunit [EC:2.7.7.7 ]
K25238 Simplexvirus DNA polymerase processivity factor
K19442 Simplexvirus major DNA-binding protein
K25239 Cytomegalovirus DNA primase [EC:2.7.7.-]
K25240 Cytomegalovirus DNA helicase/primase complex-associated protein
K25241 Cytomegalovirus DNA replication helicase [EC:5.6.2.-]
K25242 Cytomegalovirus DNA polymerase processivity factor
K25243 Cytomegalovirus major DNA-binding protein
K25244 Lymphocryptovirus DNA primase [EC:2.7.7.-]
K25245 Lymphocryptovirus DNA helicase/primase complex-associated protein
K25246 Lymphocryptovirus DNA replication helicase [EC:5.6.2.-]
K25247 Lymphocryptovirus DNA polymerase processivity factor
K25248 Lymphocryptovirus major DNA-binding protein
K25249 Roseolovirus DNA primase [EC:2.7.7.-]
K25250 Roseolovirus DNA helicase/primase complex-associated protein
K25251 Roseolovirus DNA replication helicase [EC:5.6.2.-]
K25252 Roseolovirus DNA polymerase processivity factor
K25253 Roseolovirus major DNA-binding protein
K25256 Mastadenovirus DNA-binding protein
K25257 Mastadenovirus E1A protein
K25258 Mastadenovirus E1B protein
K25259 Mastadenovirus E4 protein
K21082 Poxviridae DNA polymerase processivity factor component
K25269 Poxviridae ssDNA-binding phosphoprotein
K25270 Poxviridae late transcription elongation factor H5
K21080 Poxviridae RNA polymerase-associated transcription-specificity factor
K25273 Poxviridae DNA-directed RNA polymerase 147 kDa subunit [EC:2.7.7.6 ]
K25274 Poxviridae DNA-directed RNA polymerase 133 kDa subunit [EC:2.7.7.6 ]
K25275 Poxviridae DNA-directed RNA polymerase 30 kDa subunit [EC:2.7.7.6 ]
K25276 Poxviridae DNA-directed RNA polymerase 35 kDa subunit [EC:2.7.7.6 ]
K25277 Poxviridae DNA-directed RNA polymerase 22 kDa subunit [EC:2.7.7.6 ]
K25278 Poxviridae DNA-directed RNA polymerase 7 kDa subunit [EC:2.7.7.6 ]
K25279 Poxviridae DNA-directed RNA polymerase 19 kDa subunit [EC:2.7.7.6 ]
K21081 Poxviridae DNA-directed RNA polymerase 18 kDa subunit [EC:2.7.7.6 ]
K18948 Straboviridae DNA primase [EC:2.7.7.-]
K18949 Straboviridae DNA helicase loader
K18943 Straboviridae DNA polymerase processivity component
K18946 Straboviridae single-stranded DNA-binding protein
K18944 Straboviridae sliding clamp loader
K18945 Straboviridae sliding clamp loader
K21502 Autographiviridae DNA primase/helicase [EC:2.7.7.- 5.6.2.3 ]
K21238 Autographiviridae DNA-directed DNA polymerase [EC:2.7.7.7 ]
K25280 Autographiviridae single-stranded DNA-binding protein
K24598 Rotavirus core capsid protein VP2
K25312 Coltivirus RNA methyltransferase VP2 [EC:2.1.1.-]
K25014 SARS coronavirus non-structural protein 4
K25016 SARS coronavirus non-structural protein 6
K25017 SARS coronavirus non-structural protein 7
K25018 SARS coronavirus non-structural protein 8
K25019 SARS coronavirus non-structural protein 9
K25023 SARS coronavirus proofreading exoribonuclease [EC:3.1.13.-]
K25020 SARS coronavirus non-structural protein 10
K25025 SARS coronavirus 2'-O-methyltransferase [EC:2.1.1.-]
K25297 Enterovirus viral protein genome-linked
K25295 Enterovirus protein 3AB
K25298 Enterovirus protein 3CD
K25322 Norovirus viral genome-linked protein
K25326 Flavivirus non-structural protein 4B
K25327 Flavivirus non-structural protein 1
K25329 Flavivirus serine protease subunit NS2B
K25330 Flavivirus non-structural protein 4A
K25331 Flavivirus non-structural protein 2A
K22498 Hepatitis C virus non-structural protein 4B
K22497 Hepatitis C virus non-structural protein 2 [EC:3.4.22.-]
K22274 Hepatitis C virus non-structural protein 4A
K22275 Hepatitis C virus non-structural protein 5A
K25334 Ebolavirus polymerase cofactor VP35
K25335 Ebolavirus nucleoprotein
K25337 Marburgvirus polymerase cofactor VP35
K25338 Marburgvirus nucleoprotein
K19377 Morbillivirus phosphoprotein
K19380 Morbillivirus nucleoprotein
K25339 Respirovirus phosphoprotein
K25340 Respirovirus nucleoprotein
K25341 Lyssavirus phosphoprotein
K25342 Lyssavirus nucleoprotein
K19390 Influenza virus polymerase acidic protein
K19389 Influenza virus RNA-directed RNA polymerase catalytic subunit [EC:2.7.7.48 ]
K19388 Influenza virus polymerase basic protein 2
K19391 Influenza virus nucleoprotein
K25303 Mammarenavirus RNA-directed RNA polymerase L [EC:2.7.7.48 3.1.-.-]
K25301 Mammarenavirus nucleoprotein [EC:3.1.13.-]
K25345 Peribunyaviridae RNA-directed RNA polymerase L [EC:2.7.7.48 3.1.-.-]
K25346 Orthobunyavirus nucleoprotein
K25348 Orthonairovirus nucleoprotein
Reference Authors Koonin EV, Dolja VV, Krupovic M, Varsani A, Wolf YI, Yutin N, Zerbini FM, Kuhn JH
Title Global Organization and Proposed Megataxonomy of the Virus World.
Journal Reference Authors Hartenian E, Nandakumar D, Lari A, Ly M, Tucker JM, Glaunsinger BA
Title The molecular virology of coronaviruses.
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Title Replication and recombination of herpes simplex virus DNA.
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Title Viral and cellular interactions during adenovirus DNA replication.
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Title Binding Affinities among DNA Helicase-Primase, DNA Polymerase, and Replication Intermediates in the Replisome of Bacteriophage T7.
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Title Rotavirus Replication: Gaps of Knowledge on Virus Entry and Morphogenesis.
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Title Coltiviruses and seadornaviruses in North America, Europe, and Asia.
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Title The life cycle of non-polio enteroviruses and how to target it.
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Title Flaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA Capping.
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Title The alphaviruses: gene expression, replication, and evolution.
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Title Phosphorylation of Ebola virus VP30 influences the composition of the viral nucleocapsid complex: impact on viral transcription and replication.
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Title Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
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Title Structure of a rabies virus polymerase complex from electron cryo-microscopy.
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Title The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design.
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Title Virus(-)Host Interactions Involved in Lassa Virus Entry and Genome Replication.
Journal Reference Authors Te Velthuis AJW, Grimes JM, Fodor E
Title Structural insights into RNA polymerases of negative-sense RNA viruses.
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Title The structural biology of HIV-1: mechanistic and therapeutic insights.
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Title Molecular Studies of HTLV-1 Replication: An Update.
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Title Molecular anatomy and pathophysiologic implications of drug resistance in hepatitis B virus infection.
Journal Reference Authors Wang L, Sarafianos SG, Wang Z
Title Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
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