KEGG   PATHWAY: csyr04150
Entry
csyr04150                   Pathway                                
Name
mTOR signaling pathway - Carlito syrichta (Philippine tarsier)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
csyr04150  mTOR signaling pathway
csyr04150

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103262117  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
103255623  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
103268240  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X2 [KO:K14995]
103257766  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103261161  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103276577  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103254908  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
103267979  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
103274462  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
103255516  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103274224  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
103265947  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
103270146  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
103264706  ATP6V1G3; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 3 [KO:K02152]
103259547  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
103251850  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103258973  ragulator complex protein LAMTOR1-like [KO:K20397]
103268500  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
103274528  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
103256043  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103251687  LAMTOR4; LOW QUALITY PROTEIN: ragulator complex protein LAMTOR4 [KO:K20399]
103270998  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
103274546  FLCN; folliculin [KO:K09594]
103264105  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
103257649  FNIP2; folliculin-interacting protein 2 [KO:K20401]
103274903  ras-related GTP-binding protein B isoform X1 [KO:K16185]
103266479  RRAGA; ras-related GTP-binding protein A [KO:K16185]
103255659  RRAGD; ras-related GTP-binding protein D [KO:K16186]
103266774  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
103274114  SESN2; sestrin-2 [KO:K20394]
103258507  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X2 [KO:K23080]
103270041  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
103265536  MIOS; GATOR complex protein MIOS [KO:K20407]
103261292  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
103250080  WDR24; GATOR complex protein WDR24 [KO:K20408]
103270183  WDR59; GATOR complex protein WDR59 [KO:K20409]
103262035  SEC13; protein SEC13 homolog isoform X2 [KO:K14004]
103263880  DEPDC5; DEP domain-containing protein 5 [KO:K20404]
103255451  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
103265716  NPRL3; GATOR complex protein NPRL3 isoform X3 [KO:K20406]
103251986  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103254044  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
103251875  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103258093  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103259997  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
103252726  MLST8; target of rapamycin complex subunit LST8 isoform X2 [KO:K08266]
103272844  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
103258839  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
103262119  CLIP1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
103258744  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
103255848  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103262909  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
103277369  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
103265752  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103264896  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
103249523  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
103270915  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103253902  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X2 [KO:K03259]
103251539  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103273417  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103269722  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
103273845  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
103250033  STRADA; STE20-related kinase adapter protein alpha [KO:K08271]
103273367  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
103276207  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103253822  CAB39L; calcium-binding protein 39-like [KO:K08272]
103267335  CAB39; calcium-binding protein 39 [KO:K08272]
103254435  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103255089  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103259153  TBC1 domain family member 7 isoform X1 [KO:K20396]
103270389  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103272783  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103275084  DDIT4; DNA damage-inducible transcript 4 protein isoform X1 [KO:K08270]
103273454  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103264112  WNT2; protein Wnt-2 [KO:K00182]
103257117  WNT2B; protein Wnt-2b [KO:K00182]
103263952  WNT3A; protein Wnt-3a [KO:K00312]
103265025  WNT4; protein Wnt-4 [KO:K00408]
103270844  WNT5A; protein Wnt-5a [KO:K00444]
103262227  WNT5B; protein Wnt-5b [KO:K00444]
103261268  WNT6; protein Wnt-6 [KO:K00445]
103249204  WNT7A; LOW QUALITY PROTEIN: protein Wnt-7a [KO:K00572]
103271330  WNT7B; protein Wnt-7b [KO:K00572]
103261699  WNT8A; protein Wnt-8a [KO:K00714]
103263950  WNT9A; protein Wnt-9a [KO:K01064]
103266311  WNT9B; protein Wnt-9b [KO:K01064]
103261269  WNT10A; protein Wnt-10a [KO:K01357]
103273455  WNT10B; protein Wnt-10b [KO:K01357]
103260166  WNT11; protein Wnt-11 [KO:K01384]
103266254  WNT16; protein Wnt-16 [KO:K01558]
103262031  frizzled-1 [KO:K02432]
103257061  frizzled-1 [KO:K02432]
103267611  FZD7; frizzled-7 [KO:K02432]
103272217  FZD3; frizzled-3 [KO:K02329]
103269658  FZD4; frizzled-4 [KO:K02354]
103254909  FZD6; frizzled-6 isoform X1 [KO:K02376]
103269630  FZD9; frizzled-9 [KO:K02842]
103271891  FZD10; frizzled-10 [KO:K02842]
103263721  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103265210  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
103250886  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
103263236  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
103273282  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
103258382  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
103270149  TNF; tumor necrosis factor [KO:K03156]
103250566  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103264539  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103273081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103257652  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103271179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103260173  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103265703  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103275091  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103275641  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
103259285  IRS1; insulin receptor substrate 1 [KO:K16172]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103274296  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103265584  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103255798  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
103268932  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
103263676  PRR5L; proline-rich protein 5-like [KO:K20411]
103257469  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
103250976  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103253660  transforming protein RhoA-like [KO:K04513]
103269994  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103251444  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103276479  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103276717  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
csyr00561  Glycerolipid metabolism
csyr04010  MAPK signaling pathway
csyr04140  Autophagy - animal
csyr04151  PI3K-Akt signaling pathway
csyr04152  AMPK signaling pathway
csyr04810  Regulation of actin cytoskeleton
csyr04910  Insulin signaling pathway
KO pathway
ko04150   
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