KEGG   PATHWAY: fca04936
Entry
fca04936                    Pathway                                
Name
Alcoholic liver disease - Felis catus (domestic cat)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
fca04936  Alcoholic liver disease
fca04936

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101096082  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101096331  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101094773  C1QC; complement C1q subcomponent subunit C [KO:K03988]
101092434  C2; complement C2 isoform X3 [KO:K01332] [EC:3.4.21.43]
101094346  complement C4-A [KO:K03989]
101088468  complement C3-like [KO:K03990]
101088220  complement C3-like [KO:K03990]
111557813  complement C3-like [KO:K03990]
101099383  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
101090401  C5; complement C5 isoform X1 [KO:K03994]
101098593  C5AR1; C5a anaphylatoxin chemotactic receptor 1 isoform X1 [KO:K04010]
101097963  lipopolysaccharide-binding protein [KO:K05399]
109498011  lipopolysaccharide-binding protein-like isoform X2 [KO:K05399]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101100862  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
101088688  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101083606  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101098714  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101090622  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101096604  RELA; transcription factor p65 [KO:K04735]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
768274  IL1B; interleukin-1 beta [KO:K04519]
493687  IL6; interleukin-6 precursor [KO:K05405]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
101093854  interleukin-8-like [KO:K10030]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
101082884  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101096739  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101086282  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101095934  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
101088440  interferon alpha-2-like [KO:K05414]
101081371  interferon alpha-like [KO:K05414]
493840  IFNA5; interferon alpha-5 [KO:K05414]
111557596  interferon alpha-like [KO:K05414]
493849  IFNB1; interferon beta precursor [KO:K05415]
101095339  IL17A; interleukin-17A [KO:K05489]
101095588  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
101092091  IL17RC; interleukin-17 receptor C isoform X5 [KO:K05166]
111560177  growth-regulated alpha protein-like [KO:K05505]
102901432  formin-like protein 5 [KO:K05505]
111560178  growth-regulated alpha protein-like [KO:K05505]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101097773  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
100142684  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101087663  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101101545  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
101087535  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
100270775  FASN; fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
101083046  ACACA; acetyl-CoA carboxylase 1 isoform X7 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101091403  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
101090611  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
101085623  LPIN1; phosphatidate phosphatase LPIN1 isoform X4 [KO:K15728] [EC:3.1.3.4]
101096222  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101087178  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101087610  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
101091270  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
101101659  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
554338  ADIPOQ; adiponectin precursor [KO:K07296]
100187713  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
101085553  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
101097674  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
101096000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101095885  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
101094051  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101092284  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X3 [KO:K07199]
101094684  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
101092204  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
101100119  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
101096628  FOXO1; forkhead box protein O1 [KO:K07201]
101081548  FOXO3; forkhead box protein O3 [KO:K09408]
101081802  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
101095837  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
101096105  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101094144  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
101088421  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
101088745  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
101082279  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
101095488  FABP1; fatty acid-binding protein, liver [KO:K08750]
101100387  alcohol dehydrogenase E chain isoform X1 [KO:K13951] [EC:1.1.1.1]
101101050  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
101101307  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101081838  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
101082267  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
101096617  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X3 [KO:K00128] [EC:1.2.1.3]
101082028  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
101086623  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101080506  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
554227  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
554344  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101086680  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101086616  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
101083187  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
101095144  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
101089891  NOX4; NADPH oxidase 4 isoform X3 [KO:K21423] [EC:1.6.3.-]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101098768  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101089850  TCF7L1; transcription factor 7-like 1 isoform X3 [KO:K04490]
101095618  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101088077  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101086432  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101083468  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
fca00061  Fatty acid biosynthesis
fca00071  Fatty acid degradation
fca01040  Biosynthesis of unsaturated fatty acids
fca03040  Spliceosome
fca04010  MAPK signaling pathway
fca04064  NF-kappa B signaling pathway
fca04152  AMPK signaling pathway
fca04210  Apoptosis
fca04310  Wnt signaling pathway
fca04610  Complement and coagulation cascades
fca04620  Toll-like receptor signaling pathway
fca04657  IL-17 signaling pathway
fca04668  TNF signaling pathway
fca04920  Adipocytokine signaling pathway
fca05034  Alcoholism
fca05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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