Homo sapiens (human): 2475
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Entry
2475 CDS
T01001
Symbol
MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
Name
(RefSeq) mechanistic target of rapamycin kinase
KO
K07203
serine/threonine-protein kinase mTOR [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04012
ErbB signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04136
Autophagy - other
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04218
Cellular senescence
hsa04371
Apelin signaling pathway
hsa04613
Neutrophil extracellular trap formation
hsa04630
JAK-STAT signaling pathway
hsa04659
Th17 cell differentiation
hsa04714
Thermogenesis
hsa04910
Insulin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04935
Growth hormone synthesis, secretion and action
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05221
Acute myeloid leukemia
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415
Diabetic cardiomyopathy
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06214
PI3K signaling (cancer)
nt06224
CXCR signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06270
Breast cancer
nt06273
Glioma
nt06275
Acute myeloid leukemia
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06466
Pathways of neurodegeneration
nt06522
mTOR signaling
nt06532
Autophagy
Element
N00034
ERBB2-overexpression to PI3K signaling pathway
N00035
Amplified EGFR to PI3K signaling pathway
N00037
FGF-FGFR-PI3K signaling pathway
N00038
Amplified FGFR to PI3K signaling pathway
N00039
PDGF-PDGFR-PI3K signaling pathway
N00040
Amplified PDGFR to PI3K signaling pathway
N00042
EGFR-overexpression to PI3K signaling pathway
N00045
KITLG-KIT-PI3K signaling pathway
N00049
Mutation-activated PI3K to PI3K signaling pathway
N00050
Amplified PI3K to PI3K signaling pathway
N00154
CXCR-GNB/G-PI3K-AKT signaling pathway
N00155
Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N00218
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231
TGFA-EGFR-PI3K signaling pathway
N00234
IGF2-IGF1R-PI3K signaling pathway
N00236
IGF2-overexpression to PI3K signaling pathway
N00238
IGF1R-overexpression to PI3K signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N00260
Amplified MET to PI3K signaling pathway
N00282
EREG-EGFR-PI3K signaling pathway
N00284
AREG-EGFR-PI3K signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00963
RELN-VLDLR-PI3K signaling pathway
N01063
Mutation-activated MET to PI3K signaling pathway
N01065
Mutation-activated RET to PI3K signaling pathway
N01339
NNK/NNN to PI3K signaling pathway
N01355
Arsenic to PI3K signaling pathway
N01575
TSC1/2-mTORC1 signaling pathway
N01578
GATOR1-mTORC1 signaling pathway
N01584
FLCN-mTORC1 signaling pathway
Disease
H01251
Focal cortical dysplasia of Taylor
H01928
Smith-Kingsmore syndrome
Drug target
Apitolisib:
D10543
Bimiralisib:
D11440
Dactolisib (
DG01826
):
D10552
D10616
Everolimus:
D02714
<JP/US>
Gedatolisib:
D10635
Olcorolimus:
D10076
Omipalisib:
D10718
Onatasertib:
D11663
Paxalisib:
D11869
Ridaforolimus:
D08900
Samotolisib:
D11501
Sirolimus:
D00753
<JP/US>
Temsirolimus:
D06068
<JP/US>
Voxtalisib:
D11727
Zotarolimus:
D06669
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
2475 (MTOR)
04371 Apelin signaling pathway
2475 (MTOR)
04630 JAK-STAT signaling pathway
2475 (MTOR)
04066 HIF-1 signaling pathway
2475 (MTOR)
04072 Phospholipase D signaling pathway
2475 (MTOR)
04151 PI3K-Akt signaling pathway
2475 (MTOR)
04152 AMPK signaling pathway
2475 (MTOR)
04150 mTOR signaling pathway
2475 (MTOR)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
2475 (MTOR)
04136 Autophagy - other
2475 (MTOR)
09143 Cell growth and death
04218 Cellular senescence
2475 (MTOR)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
2475 (MTOR)
04659 Th17 cell differentiation
2475 (MTOR)
09152 Endocrine system
04910 Insulin signaling pathway
2475 (MTOR)
04920 Adipocytokine signaling pathway
2475 (MTOR)
04935 Growth hormone synthesis, secretion and action
2475 (MTOR)
04919 Thyroid hormone signaling pathway
2475 (MTOR)
09149 Aging
04211 Longevity regulating pathway
2475 (MTOR)
04213 Longevity regulating pathway - multiple species
2475 (MTOR)
09159 Environmental adaptation
04714 Thermogenesis
2475 (MTOR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2475 (MTOR)
05206 MicroRNAs in cancer
2475 (MTOR)
05205 Proteoglycans in cancer
2475 (MTOR)
05207 Chemical carcinogenesis - receptor activation
2475 (MTOR)
05230 Central carbon metabolism in cancer
2475 (MTOR)
05231 Choline metabolism in cancer
2475 (MTOR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
2475 (MTOR)
09162 Cancer: specific types
05210 Colorectal cancer
2475 (MTOR)
05212 Pancreatic cancer
2475 (MTOR)
05225 Hepatocellular carcinoma
2475 (MTOR)
05226 Gastric cancer
2475 (MTOR)
05214 Glioma
2475 (MTOR)
05221 Acute myeloid leukemia
2475 (MTOR)
05215 Prostate cancer
2475 (MTOR)
05224 Breast cancer
2475 (MTOR)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
2475 (MTOR)
05168 Herpes simplex virus 1 infection
2475 (MTOR)
05163 Human cytomegalovirus infection
2475 (MTOR)
05167 Kaposi sarcoma-associated herpesvirus infection
2475 (MTOR)
05165 Human papillomavirus infection
2475 (MTOR)
09171 Infectious disease: bacterial
05131 Shigellosis
2475 (MTOR)
09164 Neurodegenerative disease
05010 Alzheimer disease
2475 (MTOR)
05014 Amyotrophic lateral sclerosis
2475 (MTOR)
05016 Huntington disease
2475 (MTOR)
05017 Spinocerebellar ataxia
2475 (MTOR)
05022 Pathways of neurodegeneration - multiple diseases
2475 (MTOR)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
2475 (MTOR)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
2475 (MTOR)
04931 Insulin resistance
2475 (MTOR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
2475 (MTOR)
01522 Endocrine resistance
2475 (MTOR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2475 (MTOR)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
2475 (MTOR)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
2475 (MTOR)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
PIKK family [OT]
2475 (MTOR)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Other autophagy associated proteins
mTORC1 complex
2475 (MTOR)
mTORC2 complex
2475 (MTOR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
FAT
PI3_PI4_kinase
DUF3385
FRB_dom
FATC
HEAT_EZ
HEAT_2
IFRD
UME
EPSP_synthase
Motif
Other DBs
NCBI-GeneID:
2475
NCBI-ProteinID:
NP_004949
OMIM:
601231
HGNC:
3942
Ensembl:
ENSG00000198793
UniProt:
P42345
Structure
PDB
LinkDB
All DBs
Position
1:complement(11106535..11262551)
Genome browser
AA seq
2549 aa
AA seq
DB search
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq
7650 nt
NT seq
+upstream
nt +downstream
nt
atgcttggaaccggacctgccgccgccaccaccgctgccaccacatctagcaatgtgagc
gtcctgcagcagtttgccagtggcctaaagagccggaatgaggaaaccagggccaaagcc
gccaaggagctccagcactatgtcaccatggaactccgagagatgagtcaagaggagtct
actcgcttctatgaccaactgaaccatcacatttttgaattggtttccagctcagatgcc
aatgagaggaaaggtggcatcttggccatagctagcctcataggagtggaaggtgggaat
gccacccgaattggcagatttgccaactatcttcggaacctcctcccctccaatgaccca
gttgtcatggaaatggcatccaaggccattggccgtcttgccatggcaggggacactttt
accgctgagtacgtggaatttgaggtgaagcgagccctggaatggctgggtgctgaccgc
aatgagggccggagacatgcagctgtcctggttctccgtgagctggccatcagcgtccct
accttcttcttccagcaagtgcaacccttctttgacaacatttttgtggccgtgtgggac
cccaaacaggccatccgtgagggagctgtagccgcccttcgtgcctgtctgattctcaca
acccagcgtgagccgaaggagatgcagaagcctcagtggtacaggcacacatttgaagaa
gcagagaagggatttgatgagaccttggccaaagagaagggcatgaatcgggatgatcgg
atccatggagccttgttgatccttaacgagctggtccgaatcagcagcatggagggagag
cgtctgagagaagaaatggaagaaatcacacagcagcagctggtacacgacaagtactgc
aaagatctcatgggcttcggaacaaaacctcgtcacattacccccttcaccagtttccag
gctgtacagccccagcagtcaaatgccttggtggggctgctggggtacagctctcaccaa
ggcctcatgggatttgggacctcccccagtccagctaagtccaccctggtggagagccgg
tgttgcagagacttgatggaggagaaatttgatcaggtgtgccagtgggtgctgaaatgc
aggaatagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggct
gcattccgaccttctgccttcacagatacccagtatctccaagataccatgaaccatgtc
ctaagctgtgtcaagaaggagaaggaacgtacagcggccttccaagccctggggctactt
tctgtggctgtgaggtctgagtttaaggtctatttgcctcgcgtgctggacatcatccga
gcggccctgcccccaaaggacttcgcccataagaggcagaaggcaatgcaggtggatgcc
acagtcttcacttgcatcagcatgctggctcgagcaatggggccaggcatccagcaggat
atcaaggagctgctggagcccatgctggcagtgggactaagccctgccctcactgcagtg
ctctacgacctgagccgtcagattccacagctaaagaaggacattcaagatgggctactg
aaaatgctgtccctggtccttatgcacaaaccccttcgccacccaggcatgcccaagggc
ctggcccatcagctggcctctcctggcctcacgaccctccctgaggccagcgatgtgggc
agcatcactcttgccctccgaacgcttggcagctttgaatttgaaggccactctctgacc
caatttgttcgccactgtgcggatcatttcctgaacagtgagcacaaggagatccgcatg
gaggctgcccgcacctgctcccgcctgctcacaccctccatccacctcatcagtggccat
gctcatgtggttagccagaccgcagtgcaagtggtggcagatgtgcttagcaaactgctc
gtagttgggataacagatcctgaccctgacattcgctactgtgtcttggcgtccctggac
gagcgctttgatgcacacctggcccaggcggagaacttgcaggccttgtttgtggctctg
aatgaccaggtgtttgagatccgggagctggccatctgcactgtgggccgactcagtagc
atgaaccctgcctttgtcatgcctttcctgcgcaagatgctcatccagattttgacagag
ttggagcacagtgggattggaagaatcaaagagcagagtgcccgcatgctggggcacctg
gtctccaatgccccccgactcatccgcccctacatggagcctattctgaaggcattaatt
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcctggca
acaataggagaattggcacaggttagtggcctggaaatgaggaaatgggttgatgaactt
tttattatcatcatggacatgctccaggattcctctttgttggccaaaaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctatgtagtagagccctacaggaag
taccctactttgcttgaggtgctactgaattttctgaagactgagcagaaccagggtaca
cgcagagaggccatccgtgtgttagggcttttaggggctttggatccttacaagcacaaa
gtgaacattggcatgatagaccagtcccgggatgcctctgctgtcagcctgtcagaatcc
aagtcaagtcaggattcctctgactatagcactagtgaaatgctggtcaacatgggaaac
ttgcctctggatgagttctacccagctgtgtccatggtggccctgatgcggatcttccga
gaccagtcactctctcatcatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctgggactcaaatgtgtgcagttcctgccccaggtcatgcccacgttccttaacgtc
attcgagtctgtgatggggccatccgggaatttttgttccagcagctgggaatgttggtg
tcctttgtgaagagccacatcagaccttatatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcaattcagagcacgatcattcttctcattgagcaaattgtg
gtagctcttgggggtgaatttaagctctacctgccccagctgatcccacacatgctgcgt
gtcttcatgcatgacaacagcccaggccgcattgtctctatcaagttactggctgcaatc
cagctgtttggcgccaacctggatgactacctgcatttactgctgcctcctattgttaag
ttgtttgatgcccctgaagctccactgccatctcgaaaggcagcgctagagactgtggac
cgcctgacggagtccctggatttcactgactatgcctcccggatcattcaccctattgtt
cgaacactggaccagagcccagaactgcgctccacagccatggacacgctgtcttcactt
gtttttcagctggggaagaagtaccaaattttcattccaatggtgaataaagttctggtg
cgacaccgaatcaatcatcagcgctatgatgtgctcatctgcagaattgtcaagggatac
acacttgctgatgaagaggaggatcctttgatttaccagcatcggatgcttaggagtggc
caaggggatgcattggctagtggaccagtggaaacaggacccatgaagaaactgcacgtc
agcaccatcaacctccaaaaggcctggggcgctgccaggagggtctccaaagatgactgg
ctggaatggctgagacggctgagcctggagctgctgaaggactcatcatcgccctccctg
cgctcctgctgggccctggcacaggcctacaacccgatggccagggatctcttcaatgct
gcatttgtgtcctgctggtctgaactgaatgaagatcaacaggatgagctcatcagaagc
atcgagttggccctcacctcacaagacatcgctgaagtcacacagaccctcttaaacttg
gctgaattcatggaacacagtgacaagggccccctgccactgagagatgacaatggcatt
gttctgctgggtgagagagctgccaagtgccgagcatatgccaaagcactacactacaaa
gaactggagttccagaaaggccccacccctgccattctagaatctctcatcagcattaat
aataagctacagcagccggaggcagcggccggagtgttagaatatgccatgaaacacttt
ggagagctggagatccaggctacctggtatgagaaactgcacgagtgggaggatgccctt
gtggcctatgacaagaaaatggacaccaacaaggacgacccagagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatggggtcaactccaccagcagtgctgtgaaaag
tggaccctggttaatgatgagacccaagccaagatggcccggatggctgctgcagctgca
tggggtttaggtcagtgggacagcatggaagaatacacctgtatgatccctcgggacacc
catgatggggcattttatagagctgtgctggcactgcatcaggacctcttctccttggca
caacagtgcattgacaaggccagggacctgctggatgctgaattaactgcgatggcagga
gagagttacagtcgggcatatggggccatggtttcttgccacatgctgtccgagctggag
gaggttatccagtacaaacttgtccccgagcgacgagagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtatcgtagaggactggcagaaaatccttatggtgcgg
tcccttgtggtcagccctcatgaagacatgagaacctggctcaagtatgcaagcctgtgc
ggcaagagtggcaggctggctcttgctcataaaactttagtgttgctcctgggagttgat
ccgtctcggcaacttgaccatcctctgccaacagttcaccctcaggtgacctatgcctac
atgaaaaacatgtggaagagtgcccgcaagatcgatgccttccagcacatgcagcatttt
gtccagaccatgcagcaacaggcccagcatgccatcgctactgaggaccagcagcataag
caggaactgcacaagctcatggcccgatgcttcctgaaacttggagagtggcagctgaat
ctacagggcatcaatgagagcacaatccccaaagtgctgcagtactacagcgccgccaca
gagcacgaccgcagctggtacaaggcctggcatgcgtgggcagtgatgaacttcgaagct
gtgctacactacaaacatcagaaccaagcccgcgatgagaagaagaaactgcgtcatgcc
agcggggccaacatcaccaacgccaccactgccgccaccacggccgccactgccaccacc
actgccagcaccgagggcagcaacagtgagagcgaggccgagagcaccgagaacagcccc
accccatcgccgctgcagaagaaggtcactgaggatctgtccaaaaccctcctgatgtac
acggtgcctgccgtccagggcttcttccgttccatctccttgtcacgaggcaacaacctc
caggatacactcagagttctcaccttatggtttgattatggtcactggccagatgtcaat
gaggccttagtggagggggtgaaagccatccagattgatacctggctacaggttatacct
cagctcattgcaagaattgatacgcccagacccttggtgggacgtctcattcaccagctt
ctcacagacattggtcggtaccacccccaggccctcatctacccactgacagtggcttct
aagtctaccacgacagcccggcacaatgcagccaacaagattctgaagaacatgtgtgag
cacagcaacaccctggtccagcaggccatgatggtgagcgaggagctgatccgagtggcc
atcctctggcatgagatgtggcatgaaggcctggaagaggcatctcgtttgtactttggg
gaaaggaacgtgaaaggcatgtttgaggtgctggagcccttgcatgctatgatggaacgg
ggcccccagactctgaaggaaacatcctttaatcaggcctatggtcgagatttaatggag
gcccaagagtggtgcaggaagtacatgaaatcagggaatgtcaaggacctcacccaagcc
tgggacctctattatcatgtgttccgacgaatctcaaagcagctgcctcagctcacatcc
ttagagctgcaatatgtttccccaaaacttctgatgtgccgggaccttgaattggctgtg
ccaggaacatatgaccccaaccagccaatcattcgcattcagtccatagcaccgtctttg
caagtcatcacatccaagcagaggccccggaaattgacacttatgggcagcaacggacat
gagtttgttttccttctaaaaggccatgaagatctgcgccaggatgagcgtgtgatgcag
ctcttcggcctggttaacacccttctggccaatgacccaacatctcttcggaaaaacctc
agcatccagagatacgctgtcatccctttatcgaccaactcgggcctcattggctgggtt
ccccactgtgacacactgcacgccctcatccgggactacagggagaagaagaagatcctt
ctcaacatcgagcatcgcatcatgttgcggatggctccggactatgaccacttgactctg
atgcagaaggtggaggtgtttgagcatgccgtcaataatacagctggggacgacctggcc
aagctgctgtggctgaaaagccccagctccgaggtgtggtttgaccgaagaaccaattat
acccgttctttagcggtcatgtcaatggttgggtatattttaggcctgggagatagacac
ccatccaacctgatgctggaccgtctgagtgggaagatcctgcacattgactttggggac
tgctttgaggttgctatgacccgagagaagtttccagagaagattccatttagactaaca
agaatgttgaccaatgctatggaggttacaggcctggatggcaactacagaatcacatgc
cacacagtgatggaggtgctgcgagagcacaaggacagtgtcatggccgtgctggaagcc
tttgtctatgaccccttgctgaactggaggctgatggacacaaataccaaaggcaacaag
cgatcccgaacgaggacggattcctactctgctggccagtcagtcgaaattttggacggt
gtggaacttggagagccagcccataagaaaacggggaccacagtgccagaatctattcat
tctttcattggagacggtttggtgaaaccagaggccctaaataagaaagctatccagatt
attaacagggttcgagataagctcactggtcgggacttctctcatgatgacactttggat
gttccaacgcaagttgagctgctcatcaaacaagcgacatcccatgaaaacctctgccag
tgctatattggctggtgccctttctggtaa
Homo sapiens (human): 4790
Help
Entry
4790 CDS
T01001
Symbol
NFKB1, CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NF-kappabeta, NFKB-p105, NFKB-p50, NFkappaB
Name
(RefSeq) nuclear factor kappa B subunit 1
KO
K02580
nuclear factor NF-kappa-B p105 subunit
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04218
Cellular senescence
hsa04380
Osteoclast differentiation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04917
Prolactin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04926
Relaxin signaling pathway
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05212
Pancreatic cancer
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321
Inflammatory bowel disease
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06519
RLR signaling
nt06521
NLR signaling
Element
N00140
FUS-DDIT3 fusion to NFKB-mediated transcription
N00151
TNF-NFKB signaling pathway
N00171
KSHV vFLIP to NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00265
EBV LMP1 to NFKB signaling pathway
N00269
HCV core to TNF-NFKB signaling pathway
N00389
HCMV IE1-72 to transcription
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00398
HCMV IE2-86 to TNF-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00436
HIV Tat to TLR2/4-NFKB signaling pathway
N00437
HIV Vpu to TLR2/4-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00443
HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00504
HTLV-1 Tax to NFKB signaling pathway
N00550
HBV HBeAg to TLR2/4-NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00563
TLR3-NFKB signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00689
MV V/P/C to RIG-I-NFKB signaling pathway
N00730
IAV NS1 to RIG-I-like receptor signaling pathway
N00932
Escherichia NleH1 to TNF-NFKB signaling pathway
N00940
NOD-NFKB signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01112
Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01118
Salmonella SpvD to TNF-NFKB signaling pathway
N01306
AngII-AT1R-NOX2 signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01339
NNK/NNN to PI3K signaling pathway
N01410
Metals to NFKB signaling pathway
N01411
Metals to NFKB signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00088
Common variable immunodeficiency
Drug target
Iguratimod:
D01146
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
4790 (NFKB1)
04014 Ras signaling pathway
4790 (NFKB1)
04064 NF-kappa B signaling pathway
4790 (NFKB1)
04668 TNF signaling pathway
4790 (NFKB1)
04066 HIF-1 signaling pathway
4790 (NFKB1)
04071 Sphingolipid signaling pathway
4790 (NFKB1)
04024 cAMP signaling pathway
4790 (NFKB1)
04151 PI3K-Akt signaling pathway
4790 (NFKB1)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
4790 (NFKB1)
04218 Cellular senescence
4790 (NFKB1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
4790 (NFKB1)
04620 Toll-like receptor signaling pathway
4790 (NFKB1)
04621 NOD-like receptor signaling pathway
4790 (NFKB1)
04622 RIG-I-like receptor signaling pathway
4790 (NFKB1)
04623 Cytosolic DNA-sensing pathway
4790 (NFKB1)
04625 C-type lectin receptor signaling pathway
4790 (NFKB1)
04660 T cell receptor signaling pathway
4790 (NFKB1)
04658 Th1 and Th2 cell differentiation
4790 (NFKB1)
04659 Th17 cell differentiation
4790 (NFKB1)
04657 IL-17 signaling pathway
4790 (NFKB1)
04662 B cell receptor signaling pathway
4790 (NFKB1)
04062 Chemokine signaling pathway
4790 (NFKB1)
09152 Endocrine system
04920 Adipocytokine signaling pathway
4790 (NFKB1)
04917 Prolactin signaling pathway
4790 (NFKB1)
04926 Relaxin signaling pathway
4790 (NFKB1)
09156 Nervous system
04722 Neurotrophin signaling pathway
4790 (NFKB1)
09158 Development and regeneration
04380 Osteoclast differentiation
4790 (NFKB1)
09149 Aging
04211 Longevity regulating pathway
4790 (NFKB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4790 (NFKB1)
05202 Transcriptional misregulation in cancer
4790 (NFKB1)
05206 MicroRNAs in cancer
4790 (NFKB1)
05207 Chemical carcinogenesis - receptor activation
4790 (NFKB1)
05208 Chemical carcinogenesis - reactive oxygen species
4790 (NFKB1)
05203 Viral carcinogenesis
4790 (NFKB1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
4790 (NFKB1)
09162 Cancer: specific types
05212 Pancreatic cancer
4790 (NFKB1)
05221 Acute myeloid leukemia
4790 (NFKB1)
05220 Chronic myeloid leukemia
4790 (NFKB1)
05215 Prostate cancer
4790 (NFKB1)
05222 Small cell lung cancer
4790 (NFKB1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
4790 (NFKB1)
05170 Human immunodeficiency virus 1 infection
4790 (NFKB1)
05161 Hepatitis B
4790 (NFKB1)
05160 Hepatitis C
4790 (NFKB1)
05171 Coronavirus disease - COVID-19
4790 (NFKB1)
05164 Influenza A
4790 (NFKB1)
05162 Measles
4790 (NFKB1)
05168 Herpes simplex virus 1 infection
4790 (NFKB1)
05163 Human cytomegalovirus infection
4790 (NFKB1)
05167 Kaposi sarcoma-associated herpesvirus infection
4790 (NFKB1)
05169 Epstein-Barr virus infection
4790 (NFKB1)
05165 Human papillomavirus infection
4790 (NFKB1)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
4790 (NFKB1)
05130 Pathogenic Escherichia coli infection
4790 (NFKB1)
05132 Salmonella infection
4790 (NFKB1)
05131 Shigellosis
4790 (NFKB1)
05135 Yersinia infection
4790 (NFKB1)
05133 Pertussis
4790 (NFKB1)
05134 Legionellosis
4790 (NFKB1)
05152 Tuberculosis
4790 (NFKB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
4790 (NFKB1)
05145 Toxoplasmosis
4790 (NFKB1)
05140 Leishmaniasis
4790 (NFKB1)
05142 Chagas disease
4790 (NFKB1)
09163 Immune disease
05321 Inflammatory bowel disease
4790 (NFKB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
4790 (NFKB1)
05022 Pathways of neurodegeneration - multiple diseases
4790 (NFKB1)
09165 Substance dependence
05030 Cocaine addiction
4790 (NFKB1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4790 (NFKB1)
05418 Fluid shear stress and atherosclerosis
4790 (NFKB1)
05415 Diabetic cardiomyopathy
4790 (NFKB1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
4790 (NFKB1)
04932 Non-alcoholic fatty liver disease
4790 (NFKB1)
04931 Insulin resistance
4790 (NFKB1)
04933 AGE-RAGE signaling pathway in diabetic complications
4790 (NFKB1)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
4790 (NFKB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
4790 (NFKB1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
RHR (Rel homology region) Rel/Ankyrin
4790 (NFKB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RHD_DNA_bind
RHD_dimer
Ank_2
Ank
Ank_4
Ank_3
Ank_5
Death
Motif
Other DBs
NCBI-GeneID:
4790
NCBI-ProteinID:
NP_001158884
OMIM:
164011
HGNC:
7794
Ensembl:
ENSG00000109320
UniProt:
P19838
Structure
PDB
LinkDB
All DBs
Position
4:102501359..102617302
Genome browser
AA seq
968 aa
AA seq
DB search
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
NT seq
2907 nt
NT seq
+upstream
nt +downstream
nt
atggcagaagatgatccatatttgggaaggcctgaacaaatgtttcatttggatccttct
ttgactcatacaatatttaatccagaagtatttcaaccacagatggcactgccaacagat
ggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgta
tgtgaaggcccatcccatggtggactacctggtgcctctagtgaaaagaacaagaagtct
taccctcaggtcaaaatctgcaactatgtgggaccagcaaaggttattgttcagttggtc
acaaatggaaaaaatatccacctgcatgcccacagcctggtgggaaaacactgtgaggat
gggatctgcactgtaactgctggacccaaggacatggtggtcggcttcgcaaacctgggt
atacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcg
tgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagca
gaaggtggaggggaccggcagctgggagatcgggaaaaagagctaatccgccaagcagct
ctgcagcagaccaaggagatggacctcagcgtggtgcggctcatgtttacagcttttctt
ccggatagcactggcagcttcacaaggcgcctggaacccgtggtatcagacgccatctat
gacagtaaagcccccaatgcatccaacttgaaaattgtaagaatggacaggacagctgga
tgtgtgactggaggggaggaaatttatcttctttgtgacaaagttcagaaagatgacatc
cagattcgattttatgaagaggaagaaaatggtggagtctgggaaggatttggagatttt
tcccccacagatgttcatagacaatttgccattgtcttcaaaactccaaagtataaagat
attaatattacaaaaccagcctctgtgtttgtccagcttcggaggaaatctgacttggaa
actagtgaaccaaaacctttcctctactatcctgaaatcaaagataaagaagaagtgcag
aggaaacgtcagaagctcatgcccaatttttcggatagtttcggcggtggtagtggtgct
ggagctggaggcggaggcatgtttggtagtggcggtggaggagggggcactggaagtaca
ggtccagggtatagcttcccacactatggatttcctacttatggtgggattactttccat
cctggaactactaaatctaatgctgggatgaagcatggaaccatggacactgaatctaaa
aaggaccctgaaggttgtgacaaaagtgatgacaaaaacactgtaaacctctttgggaaa
gttattgaaaccacagagcaagatcaggagcccagcgaggccaccgttgggaatggtgag
gtcactctaacgtatgcaacaggaacaaaagaagagagtgctggagttcaggataacctc
tttctagagaaggctatgcagcttgcaaagaggcatgccaatgcccttttcgactacgcg
gtgacaggagacgtgaagatgctgctggccgtccagcgccatctcactgctgtgcaggat
gagaatggggacagtgtcttacacttagcaatcatccaccttcattctcaacttgtgagg
gatctactagaagtcacatctggtttgatttctgatgacattatcaacatgagaaatgat
ctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggat
ttgctgagggctggggccgacctgagccttctggaccgcttgggtaactctgttttgcac
ctagctgccaaagaaggacatgataaagttctcagtatcttactcaagcacaaaaaggca
gcactacttcttgaccaccccaacggggacggtctgaatgccattcatctagccatgatg
agcaatagcctgccatgtttgctgctgctggtggccgctggggctgacgtcaatgctcag
gagcagaagtccgggcgcacagcactgcacctggctgtggagcacgacaacatctcattg
gcaggctgcctgctcctggagggtgatgcccatgtggacagtactacctacgatggaacc
acacccctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagca
gcaggagcagatcccctggtggagaactttgagcctctctatgacctggatgactcttgg
gaaaatgcaggagaggatgaaggagttgtgcctggaaccacgcctctagatatggccacc
agctggcaggtatttgacatattaaatgggaaaccatatgagccagagtttacatctgat
gatttactagcacaaggagacatgaaacagctggctgaagatgtgaagctgcagctgtat
aagttactagaaattcctgatccagacaaaaactgggctactctggcgcagaaattaggt
ctggggatacttaataatgccttccggctgagtcctgctccttccaaaacacttatggac
aactatgaggtctctgggggtacagtcagagagctggtggaggccctgagacaaatgggc
tacaccgaagcaattgaagtgatccaggcagcctccagcccagtgaagaccacctctcag
gcccactcgctgcctctctcgcctgcctccacaaggcagcaaatagacgagctccgagac
agtgacagtgtctgcgacagcggcgtggagacatccttccgcaaactcagctttaccgag
tctctgaccagtggtgcctcactgctaactctcaacaaaatgccccatgattatgggcag
gaaggacctctagaaggcaaaatttag
Homo sapiens (human): 5970
Help
Entry
5970 CDS
T01001
Symbol
RELA, AIF3BL3, CMCU, NFKB3, p65
Name
(RefSeq) RELA proto-oncogene, NF-kB subunit
KO
K04735
transcription factor p65
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04137
Mitophagy - animal
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04211
Longevity regulating pathway
hsa04218
Cellular senescence
hsa04380
Osteoclast differentiation
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04917
Prolactin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04926
Relaxin signaling pathway
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05030
Cocaine addiction
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05212
Pancreatic cancer
hsa05215
Prostate cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321
Inflammatory bowel disease
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06519
RLR signaling
nt06521
NLR signaling
Element
N00140
FUS-DDIT3 fusion to NFKB-mediated transcription
N00151
TNF-NFKB signaling pathway
N00171
KSHV vFLIP to NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00265
EBV LMP1 to NFKB signaling pathway
N00269
HCV core to TNF-NFKB signaling pathway
N00389
HCMV IE1-72 to transcription
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00398
HCMV IE2-86 to TNF-NFKB signaling pathway
N00399
CCR2-GNB/G-PI3K-NFKB signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00436
HIV Tat to TLR2/4-NFKB signaling pathway
N00437
HIV Vpu to TLR2/4-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00443
HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00504
HTLV-1 Tax to NFKB signaling pathway
N00550
HBV HBeAg to TLR2/4-NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00563
TLR3-NFKB signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00689
MV V/P/C to RIG-I-NFKB signaling pathway
N00730
IAV NS1 to RIG-I-like receptor signaling pathway
N00929
Escherichia NleC to TNF-NFKB signaling pathway
N00932
Escherichia NleH1 to TNF-NFKB signaling pathway
N00940
NOD-NFKB signaling pathway
N00943
Shigella IpaH4.5 to TNF-NFKB signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01112
Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01118
Salmonella SpvD to TNF-NFKB signaling pathway
N01122
Salmonella PipA/GogA/GtgA to TNF-NFKB signaling pathway
N01306
AngII-AT1R-NOX2 signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01339
NNK/NNN to PI3K signaling pathway
N01410
Metals to NFKB signaling pathway
N01411
Metals to NFKB signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H02593
Chronic mucocutaneous ulceration
Drug target
Edasalonexent:
D12181
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5970 (RELA)
04014 Ras signaling pathway
5970 (RELA)
04064 NF-kappa B signaling pathway
5970 (RELA)
04668 TNF signaling pathway
5970 (RELA)
04066 HIF-1 signaling pathway
5970 (RELA)
04071 Sphingolipid signaling pathway
5970 (RELA)
04024 cAMP signaling pathway
5970 (RELA)
04151 PI3K-Akt signaling pathway
5970 (RELA)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
5970 (RELA)
09143 Cell growth and death
04210 Apoptosis
5970 (RELA)
04218 Cellular senescence
5970 (RELA)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
5970 (RELA)
04620 Toll-like receptor signaling pathway
5970 (RELA)
04621 NOD-like receptor signaling pathway
5970 (RELA)
04622 RIG-I-like receptor signaling pathway
5970 (RELA)
04623 Cytosolic DNA-sensing pathway
5970 (RELA)
04625 C-type lectin receptor signaling pathway
5970 (RELA)
04660 T cell receptor signaling pathway
5970 (RELA)
04658 Th1 and Th2 cell differentiation
5970 (RELA)
04659 Th17 cell differentiation
5970 (RELA)
04657 IL-17 signaling pathway
5970 (RELA)
04662 B cell receptor signaling pathway
5970 (RELA)
04062 Chemokine signaling pathway
5970 (RELA)
09152 Endocrine system
04920 Adipocytokine signaling pathway
5970 (RELA)
04917 Prolactin signaling pathway
5970 (RELA)
04926 Relaxin signaling pathway
5970 (RELA)
09156 Nervous system
04722 Neurotrophin signaling pathway
5970 (RELA)
09158 Development and regeneration
04380 Osteoclast differentiation
5970 (RELA)
09149 Aging
04211 Longevity regulating pathway
5970 (RELA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5970 (RELA)
05202 Transcriptional misregulation in cancer
5970 (RELA)
05207 Chemical carcinogenesis - receptor activation
5970 (RELA)
05208 Chemical carcinogenesis - reactive oxygen species
5970 (RELA)
05203 Viral carcinogenesis
5970 (RELA)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5970 (RELA)
09162 Cancer: specific types
05212 Pancreatic cancer
5970 (RELA)
05221 Acute myeloid leukemia
5970 (RELA)
05220 Chronic myeloid leukemia
5970 (RELA)
05215 Prostate cancer
5970 (RELA)
05222 Small cell lung cancer
5970 (RELA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5970 (RELA)
05170 Human immunodeficiency virus 1 infection
5970 (RELA)
05161 Hepatitis B
5970 (RELA)
05160 Hepatitis C
5970 (RELA)
05171 Coronavirus disease - COVID-19
5970 (RELA)
05164 Influenza A
5970 (RELA)
05162 Measles
5970 (RELA)
05168 Herpes simplex virus 1 infection
5970 (RELA)
05163 Human cytomegalovirus infection
5970 (RELA)
05167 Kaposi sarcoma-associated herpesvirus infection
5970 (RELA)
05169 Epstein-Barr virus infection
5970 (RELA)
05165 Human papillomavirus infection
5970 (RELA)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5970 (RELA)
05130 Pathogenic Escherichia coli infection
5970 (RELA)
05132 Salmonella infection
5970 (RELA)
05131 Shigellosis
5970 (RELA)
05135 Yersinia infection
5970 (RELA)
05133 Pertussis
5970 (RELA)
05134 Legionellosis
5970 (RELA)
05152 Tuberculosis
5970 (RELA)
09174 Infectious disease: parasitic
05146 Amoebiasis
5970 (RELA)
05145 Toxoplasmosis
5970 (RELA)
05140 Leishmaniasis
5970 (RELA)
05142 Chagas disease
5970 (RELA)
09163 Immune disease
05321 Inflammatory bowel disease
5970 (RELA)
09164 Neurodegenerative disease
05010 Alzheimer disease
5970 (RELA)
05022 Pathways of neurodegeneration - multiple diseases
5970 (RELA)
09165 Substance dependence
05030 Cocaine addiction
5970 (RELA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5970 (RELA)
05418 Fluid shear stress and atherosclerosis
5970 (RELA)
05415 Diabetic cardiomyopathy
5970 (RELA)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
5970 (RELA)
04932 Non-alcoholic fatty liver disease
5970 (RELA)
04931 Insulin resistance
5970 (RELA)
04933 AGE-RAGE signaling pathway in diabetic complications
5970 (RELA)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
5970 (RELA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
5970 (RELA)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
RHR (Rel homology region) Rel/Ankyrin
5970 (RELA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RHD_DNA_bind
RHD_dimer
Motif
Other DBs
NCBI-GeneID:
5970
NCBI-ProteinID:
NP_068810
OMIM:
164014
HGNC:
9955
Ensembl:
ENSG00000173039
UniProt:
Q04206
Structure
PDB
LinkDB
All DBs
Position
11:complement(65653601..65663857)
Genome browser
AA seq
551 aa
AA seq
DB search
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
NT seq
1656 nt
NT seq
+upstream
nt +downstream
nt
atggacgaactgttccccctcatcttcccggcagagccagcccaggcctctggcccctat
gtggagatcattgagcagcccaagcagcggggcatgcgcttccgctacaagtgcgagggg
cgctccgcgggcagcatcccaggcgagaggagcacagataccaccaagacccaccccacc
atcaagatcaatggctacacaggaccagggacagtgcgcatctccctggtcaccaaggac
cctcctcaccggcctcacccccacgagcttgtaggaaaggactgccgggatggcttctat
gaggctgagctctgcccggaccgctgcatccacagtttccagaacctgggaatccagtgt
gtgaagaagcgggacctggagcaggctatcagtcagcgcatccagaccaacaacaacccc
ttccaagttcctatagaagagcagcgtggggactacgacctgaatgctgtgcggctctgc
ttccaggtgacagtgcgggacccatcaggcaggcccctccgcctgccgcctgtcctttct
catcccatctttgacaatcgtgcccccaacactgccgagctcaagatctgccgagtgaac
cgaaactctggcagctgcctcggtggggatgagatcttcctactgtgtgacaaggtgcag
aaagaggacattgaggtgtatttcacgggaccaggctgggaggcccgaggctccttttcg
caagctgatgtgcaccgacaagtggccattgtgttccggacccctccctacgcagacccc
agcctgcaggctcctgtgcgtgtctccatgcagctgcggcggccttccgaccgggagctc
agtgagcccatggaattccagtacctgccagatacagacgatcgtcaccggattgaggag
aaacgtaaaaggacatatgagaccttcaagagcatcatgaagaagagtcctttcagcgga
cccaccgacccccggcctccacctcgacgcattgctgtgccttcccgcagctcagcttct
gtccccaagccagcaccccagccctatccctttacgtcatccctgagcaccatcaactat
gatgagtttcccaccatggtgtttccttctgggcagatcagccaggcctcggccttggcc
ccggcccctccccaagtcctgccccaggctccagcccctgcccctgctccagccatggta
tcagctctggcccaggccccagcccctgtcccagtcctagccccaggccctcctcaggct
gtggccccacctgcccccaagcccacccaggctggggaaggaacgctgtcagaggccctg
ctgcagctgcagtttgatgatgaagacctgggggccttgcttggcaacagcacagaccca
gctgtgttcacagacctggcatccgtcgacaactccgagtttcagcagctgctgaaccag
ggcatacctgtggccccccacacaactgagcccatgctgatggagtaccctgaggctata
actcgcctagtgacaggggcccagaggccccccgacccagctcctgctccactgggggcc
ccggggctccccaatggcctcctttcaggagatgaagacttctcctccattgcggacatg
gacttctcagccctgctgagtcagatcagctcctaa
Homo sapiens (human): 332
Help
Entry
332 CDS
T01001
Symbol
BIRC5, API4, EPR-1
Name
(RefSeq) baculoviral IAP repeat containing 5
KO
K08731
baculoviral IAP repeat-containing protein 5
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04390
Hippo signaling pathway
hsa05161
Hepatitis B
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05210
Colorectal cancer
Network
nt06162
Hepatitis B virus (HBV)
nt06214
PI3K signaling (cancer)
nt06215
WNT signaling (cancer)
nt06230
Cell cycle (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06271
Endometrial cancer
nt06515
Regulation of kinetochore-microtubule interactions
Element
N00057
Mutation-inactivated APC to Wnt signaling pathway
N00058
Mutation-activated CTNNB1 to Wnt signaling pathway
N00533
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N01337
NNK/NNN to CHRNA7-E2F signaling pathway
N01339
NNK/NNN to PI3K signaling pathway
N01526
Organization of the outer kinetochore
Drug target
Gataparsen (
DG01431
):
D09909
D09910
Sepantronium bromide:
D10164
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04390 Hippo signaling pathway
332 (BIRC5)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
332 (BIRC5)
04215 Apoptosis - multiple species
332 (BIRC5)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
332 (BIRC5)
05207 Chemical carcinogenesis - receptor activation
332 (BIRC5)
09162 Cancer: specific types
05210 Colorectal cancer
332 (BIRC5)
09172 Infectious disease: viral
05161 Hepatitis B
332 (BIRC5)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
332 (BIRC5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
332 (BIRC5)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
332 (BIRC5)
Peptidases and inhibitors [BR:
hsa01002
]
Peptidase inhibitors
Family I32: IAP family
332 (BIRC5)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centromeric chromatin formation proteins
Kinetochore proteins
CPC (chromosomal passenger complex)
332 (BIRC5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
BIR
Motif
Other DBs
NCBI-GeneID:
332
NCBI-ProteinID:
NP_001159
OMIM:
603352
HGNC:
593
Ensembl:
ENSG00000089685
UniProt:
O15392
A0A0B4J1S3
Structure
PDB
LinkDB
All DBs
Position
17:78214253..78225635
Genome browser
AA seq
142 aa
AA seq
DB search
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAEKVRRAIEQLAAMD
NT seq
429 nt
NT seq
+upstream
nt +downstream
nt
atgggtgccccgacgttgccccctgcctggcagccctttctcaaggaccaccgcatctct
acattcaagaactggcccttcttggagggctgcgcctgcaccccggagcggatggccgag
gctggcttcatccactgccccactgagaacgagccagacttggcccagtgtttcttctgc
ttcaaggagctggaaggctgggagccagatgacgaccccatagaggaacataaaaagcat
tcgtccggttgcgctttcctttctgtcaagaagcagtttgaagaattaacccttggtgaa
tttttgaaactggacagagaaagagccaagaacaaaattgcaaaggaaaccaacaataag
aagaaagaatttgaggaaactgcggagaaagtgcgccgtgccatcgagcagctggctgcc
atggattga
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integrated database retrieval system