KEGG ORTHOLOGY: K05659

ORTHOLOGY: K05659

Entry

K05659                      KO

Symbol

ABCB4

Name

ATP-binding cassette, subfamily B (MDR/TAP), member 4 [EC:7.6.2.2]

Pathway

map02010

ABC transporters

map04976

Bile secretion

Disease

H00624

Progressive familial intrahepatic cholestasis

H01213

Gallbladder disease

H02193

Intrahepatic cholestasis of pregnancy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
Enzymes [BR:ko01000]
7. Translocases
  7.6  Catalysing the translocation of other compounds
   7.6.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.6.2.2  ABC-type xenobiotic transporter
     K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
Transporters [BR:ko02000]
ABC transporters, eukaryotic type
  ABCB (MDR/TAP) subfamily
   ABCB1, 4, 5 subgroups
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4

Other DBs

GO:

0008559

TC:

3.A.1.201

Genes

HSA:	5244(ABCB4)

PTR:	748364(ABCB4)

PPS:	100976274(ABCB4)

GGO:	101141298(ABCB4)

PON:

100455534

NLE:	100602308(ABCB4)

HMH:	116810860(ABCB4)

MCC:	706683(ABCB4)

MCF:	102115339(ABCB4)

MTHB:

126951269

MNI:	105475442(ABCB4)

CSAB:

103226609(ABCB4)

CATY:

105595522(ABCB4)

PANU:

101006038(ABCB4)

TGE:	112620647(ABCB4)

MLEU:

105550951(ABCB4)

RRO:	104668032(ABCB4)

RBB:

108515081

TFN:	117072398(ABCB4)

PTEH:

111552468(ABCB4)

CANG:

105525959(ABCB4)

CJC:	100398854(ABCB4)

SBQ:	101051647(ABCB4)

CIMI:

108309913(ABCB4)

CSYR:

103263646(ABCB4)

MMUR:

105879325(ABCB4)

LCAT:

123647731(ABCB4)

PCOQ:

105809669(ABCB4)

OGA:	100941619(ABCB4)

MMU:	18670(Abcb4)

MCAL:

110294486(Abcb4)

MPAH:

110316212

RNO:	24891(Abcb4)

MCOC:

116097475(Abcb4)

ANU:	117720593(Abcb4)

MUN:

110555239

CGE:	100682535(Abcb4)

MAUA:

101827092

PROB:

127214161(Abcb4)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103725175(Abcb4)

HGL:	101717251(Abcb4)

CCAN:

109689161

DORD:

105992956(Abcb4)

DSP:

122111906

PLOP:

125346969(Abcb4)

NCAR:

124991744

MMMA:

107156325(Abcb4)

OCU:

100354947

OPI:	101536241(ABCB4)

TUP:	102478068(ABCB4)

GVR:	103604812(ABCB4)

CFA:	482284(ABCB4)

CLUD:

112674995(ABCB4)

VVP:	112935084(ABCB4)

VLG:	121474668(ABCB4)

NPO:	129498288(ABCB4)

AML:	100475375(ABCB4)

UAH:	113259445(ABCB4)

UAR:	123789332(ABCB4)

ELK:

111155264

LLV:

125080472

MPUF:

101686685(ABCB4)

MNP:

132015976

MLK:	131829329(ABCB4)

NVS:	122904776(ABCB4)

ORO:	101368373(ABCB4)

EJU:	114220419(ABCB4)

ZCA:	113911239(ABCB4)

MLX:	118020707(ABCB4)

NSU:	110580161(ABCB4)

LWW:

102741359

FCA:	109497287(ABCB4)

PYU:	121028770(ABCB4)

PCOO:

112866669(ABCB4)

PBG:	122487837(ABCB4)

PVIV:

125155311(ABCB4)

LRUF:

124524791

PTG:	102972907(ABCB4)

PPAD:

109263643(ABCB4)

PUC:

125929866

AJU:

106987580

HHV:	120222235(ABCB4)

BTA:	100336913(ABCB4)

BOM:	102280988(ABCB4)

BIU:

109557315

BBUB:

102391160

CHX:	102171298(ABCB4)

OAS:

101122517

BTAX:

128046261(ABCB4)

ODA:

120878091

CCAD:

122438231

MBEZ:

129552321(ABCB4)

SSC:	100144586(ABCB4)

CFR:

102513941

CBAI:

105062361

CDK:	105087357(ABCB4)

VPC:	102537160(ABCB4)

BACU:

103002339(ABCB4)

BMUS:

118900924(ABCB4)

LVE:	103088229(ABCB4)

OOR:	101279182(ABCB4)

DLE:	111182170(ABCB4)

PCAD:

102983763(ABCB4)

PSIU:

116759679(ABCB4)

NASI:

112395342(ABCB4)

ECB:	100147513(ABCB4)

MYB:	102246156(ABCB4)

MYD:	102755637(ABCB4)

MMYO:

118666261(ABCB4)

MLF:	102429434(ABCB4)

PKL:	118714338(ABCB4)

EFUS:

129147028(ABCB4)

MNA:	107541721(ABCB4)

DRO:	112302075(ABCB4)

SHON:

119000975(ABCB4)

AJM:	119037193(ABCB4)

PDIC:

114507870(ABCB4)

PHAS:

123811391(ABCB4)

PPAM:

129063075(ABCB4)

HAI:	109371296(ABCB4)

RFQ:	117012091(ABCB4)

PALE:

102880063

PGIG:

120615075(ABCB4)

PVP:

105294804

RAY:	107512456(ABCB4)

MJV:

108409276

TOD:	119244682(ABCB4)

SARA:

101550735(ABCB4)

SETR:

126005159(ABCB4)

LAV:	100662269(ABCB4)

TMU:

101349036

ETF:	101638263(ABCB4)

DNM:	101424470(ABCB4)

MDO:	100462975(ABCB4)

GAS:

SHR:

AFZ:

PCW:

OAA:	100077786(ABCB4)

GGA:	420534(ABCB1LA)

PCOC:

116243230

MGP:	100548646(ABCB1)

CJO:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

CLV:

TALA:

GCL:

LDI:

MNB:

OHA:

DPUB:

AVIT:

BRHI:

AAM:

AROW:

NPD:

TGT:	104577100(ABCB4)

DNE:

112982321

SCAM:

104144102

ASN:

102387370

AMJ:	102558575(ABCB4)

CPOO:

109308449 109308457

GGN:	109291375 109291376(ABCB1)

CCAY:

125631396(ABCB1)

DCC:

119851057

TST:	117872178(ABCB1)

CABI:

116839971

MRV:	120399500(ABCB1)

ASAO:

132778877(ABCB1)

SUND:

121934120(ABCB1)

CTIG:

120302655

PGUT:

117655157(ABCB1)

APRI:

131197660(ABCB1)

PTEX:

113446443(ABCB1)

NSS:	113421121(ABCB1)

VKO:	123020652(ABCB1)

PRAF:

128423915(ABCB1)

HCG:	128330717(ABCB1)

STOW:

125440773(ABCB1)

EMC:

CCIN:

PPOT:

ACOO:

DVT:

HHAL:

106680715 106684013 106684014 106688466 112211270

HVI:

MQU:

FOC:

TPAL:

BROR:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

ABRU:

129960075 129965747 129965748

SDM:

GAE:

OED:

ATEN:

XEN:

TAD:	TRIADDRAFT_54424

» show all

Reference

PMID:20103563

Authors

Klaassen CD, Aleksunes LM

Title

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Journal

Pharmacol Rev 62:1-96 (2010)
DOI:10.1124/pr.109.002014

Reference

PMID:3405218

Authors

Gros P, Raymond M, Bell J, Housman D

Title

Cloning and characterization of a second member of the mouse mdr gene family.

Journal

Mol Cell Biol 8:2770-8 (1988)
DOI:10.1128/mcb.8.7.2770

Sequence

[mmu:18670]

LinkDB

DBGET integrated database retrieval system