KEGG ORTHOLOGY: K13368

ORTHOLOGY: K13368

Entry

K13368                      KO

Symbol

HSD17B2

Name

17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Reaction

R01836

testosterone:NAD+ 17-oxidoreductase

R02352

estradiol-17beta:NAD+ 17-oxidoreductase

R02353

estradiol-17beta:NADP+ 17-oxidoreductase

R04681

estriol:NAD+ 17-oxidoreductase

R04682

estriol:NADP+ 17-oxidoreductase

R08945

11beta,17beta-dihydroxy-4-androsten-3-one:NAD+ 17-oxidoreductase

R08980

11beta,17beta-dihydroxy-4-androsten-3-one:NADP+ 17-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K13368  HSD17B2; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K13368  HSD17B2; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13368  HSD17B2; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     K13368  HSD17B2; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Other DBs

GO:	0004303 0047035

Genes

HSA:	3294(HSD17B2)

PTR:	454269(HSD17B2)

PPS:	100983435(HSD17B2)

GGO:	101131453(HSD17B2)

PON:	100456547(HSD17B2)

NLE:	100588757(HSD17B2)

HMH:	116470773(HSD17B2)

MCC:	714282(HSD17B2)

MCF:	102119721(HSD17B2)

MTHB:

126943976

MNI:	105491202(HSD17B2)

CSAB:

103233373(HSD17B2)

CATY:

105598042(HSD17B2)

PANU:

101005026(HSD17B2)

TGE:	112614126(HSD17B2)

MLEU:

105546785(HSD17B2)

RRO:	104671622(HSD17B2)

RBB:	108521311(HSD17B2)

TFN:	117088115(HSD17B2)

PTEH:

111552544(HSD17B2)

CANG:

105511945(HSD17B2)

CJC:	100390710(HSD17B2)

SBQ:	101030366(HSD17B2)

CIMI:

108313464(HSD17B2)

CSYR:

103267385(HSD17B2)

MMUR:

105859478(HSD17B2)

LCAT:

123625046(HSD17B2)

PCOQ:

105813484(HSD17B2)

OGA:	100948519(HSD17B2)

MMU:	15486(Hsd17b2)

MCAL:

110299663(Hsd17b2)

MPAH:

110337701(Hsd17b2)

RNO:	79243(Hsd17b2)

MCOC:

116070254(Hsd17b2)

ANU:	117723193(Hsd17b2)

MUN:	110550260(Hsd17b2)

CGE:	100751897(Hsd17b2)

MAUA:

101841187(Hsd17b2)

PROB:

127234513(Hsd17b2)

PLEU:

114697459(Hsd17b2)

MORG:

121447250(Hsd17b2)

MFOT:

126502938

AAMP:

119801690(Hsd17b2)

NGI:	103748738(Hsd17b2)

HGL:	101719685(Hsd17b2)

CPOC:

100731231(Hsd17b2)

CCAN:

109680174

DORD:

105983081(Hsd17b2)

DSP:	122101103(Hsd17b2)

PLOP:

125357865(Hsd17b2)

NCAR:

124967024

MMMA:

107150866(Hsd17b2)

OCU:

100358604

TUP:	102481564(HSD17B2)

GVR:	103591524(HSD17B2)

CFA:	489690(HSD17B2)

CLUD:

112646725(HSD17B2)

VVP:	112912332(HSD17B2)

VLG:	121499310(HSD17B2)

NPO:	129497933(HSD17B2)

AML:	100484508(HSD17B2)

UMR:	103662132(HSD17B2)

UAH:	113252538(HSD17B2)

UAR:	123791352(HSD17B2)

ELK:

111152983

LLV:

125089092

MPUF:

101694208(HSD17B2)

MNP:	132005179(HSD17B2)

MLK:	131817958(HSD17B2)

NVS:	122911193(HSD17B2)

ORO:	101379076(HSD17B2)

EJU:	114203848(HSD17B2)

ZCA:	113936101(HSD17B2)

MLX:	118023526(HSD17B2)

NSU:	110591764(HSD17B2)

LWW:	102731014(HSD17B2)

FCA:	101085592(HSD17B2)

PYU:	121009854(HSD17B2)

PBG:	122494522(HSD17B2)

PVIV:

125153010(HSD17B2)

LRUF:

124510729

PTG:	102958819(HSD17B2)

PPAD:

109245636(HSD17B2)

PUC:

125916314

AJU:

106984011

HHV:	120225544(HSD17B2)

BTA:	515710(HSD17B2)

BOM:	102278674(HSD17B2)

BIU:	109572993(HSD17B2)

BBUB:

102406091(HSD17B2)

BBIS:

104996522(HSD17B2)

CHX:	102182621(HSD17B2)

OAS:	100913161(HSD17B2)

BTAX:

128063826(HSD17B2)

ODA:	120873244(HSD17B2)

CCAD:

122421656(HSD17B2)

MBEZ:

129547228(HSD17B2)

SSC:	100312973(HSD17B2)

CFR:	102514993(HSD17B2)

CBAI:

105078954(HSD17B2)

CDK:	105089442(HSD17B2)

VPC:	102541386(HSD17B2)

BACU:

103014202(HSD17B2)

BMUS:

118885591(HSD17B2)

LVE:	103070446(HSD17B2)

OOR:	101284697(HSD17B2)

DLE:	111179344(HSD17B2)

PSIU:

116744208(HSD17B2)

NASI:

112393444(HSD17B2)

ECB:	100146214(HSD17B2)

EPZ:	103558215(HSD17B2)

EAI:	106832532(HSD17B2)

MYB:	102260774(HSD17B2)

MYD:	102751454(HSD17B2)

MMYO:

118674766(HSD17B2)

MLF:	102419373(HSD17B2)

PKL:	118720592(HSD17B2)

EFUS:

103284405(HSD17B2)

MNA:	107525681(HSD17B2)

DRO:	112300652(HSD17B2)

SHON:

118983035(HSD17B2)

AJM:	119047101(HSD17B2)

PDIC:

114488332(HSD17B2)

PHAS:

123805995(HSD17B2)

MMF:	118639044(HSD17B2)

PPAM:

129075044(HSD17B2)

HAI:	109378375(HSD17B2)

RFQ:	117034315(HSD17B2)

PALE:

102882881(HSD17B2)

PGIG:

120622969(HSD17B2)

PVP:	105289833(HSD17B2)

RAY:	107521360(HSD17B2)

MJV:	108400471(HSD17B2)

TOD:	119249123(HSD17B2)

SARA:

101553564(HSD17B2)

SETR:

126028463(HSD17B2)

LAV:	100673988(HSD17B2)

TMU:

101341742

ETF:	101643607(HSD17B2)

DNM:	101427521(HSD17B2)

MDO:	100031815(HSD17B2)

GAS:	123237041(HSD17B2)

SHR:	100921563(HSD17B2)

AFZ:

127548675

PCW:	110212686(HSD17B2)

OAA:	100076931(HSD17B2)

GGA:	415807(HSD17B2)

PCOC:

116243844(HSD17B2)

MGP:	100549838(HSD17B2)

CJO:	107319415(HSD17B2)

TPAI:

128082058(HSD17B2)

LMUT:

125699046(HSD17B2)

NMEL:

110404501(HSD17B2)

APLA:

101792379(HSD17B2)

ACYG:

106044875(HSD17B2)

CATA:

118246468(HSD17B2)

AFUL:

116494039(HSD17B2)

TGU:	100228039(HSD17B2)

LSR:	110476239(HSD17B2)

SCAN:

103816732(HSD17B2)

PMOA:

120508045(HSD17B2)

OTC:	121334039(HSD17B2)

PRUF:

121348933(HSD17B2)

GFR:	102039377(HSD17B2)

FAB:	101810951(HSD17B2)

OMA:	130257940(HSD17B2)

PHI:	102103079(HSD17B2)

PMAJ:

107209789(HSD17B2)

CCAE:

111934744(HSD17B2)

CCW:	104691825(HSD17B2)

CBRC:

103620107(HSD17B2)

ETL:	114066564(HSD17B2)

ZAB:	102065285(HSD17B2)

ACHL:

103804388(HSD17B2)

SVG:	106852111(HSD17B2)

MMEA:

130577294(HSD17B2)

HRT:	120757739(HSD17B2)

FPG:	101915382(HSD17B2)

FCH:	102048922(HSD17B2)

CLV:	102095570(HSD17B2)

EGZ:	104133743(HSD17B2)

NNI:	104014591(HSD17B2)

PCRI:

104035479(HSD17B2)

PLET:

104620781(HSD17B2)

EHS:

104508678

PCAO:

104052762(HSD17B2)

ACUN:

113484357(HSD17B2)

TALA:

104357344(HSD17B2)

PADL:

103923867(HSD17B2)

AFOR:

103897306(HSD17B2)

ACHC:

115346618(HSD17B2)

HALD:

104318019(HSD17B2)

HLE:	104839382(HSD17B2)

AGEN:

126040701

GCL:

127021144

CCRI:

104164321(HSD17B2)

CSTI:

104559017(HSD17B2)

CMAC:

104480014

MUI:	104536601(HSD17B2)

BREG:

104639884(HSD17B2)

FGA:	104080739(HSD17B2)

GSTE:

104261743(HSD17B2)

LDI:	104344058(HSD17B2)

MNB:	103777206(HSD17B2)

OHA:	104339199(HSD17B2)

NNT:

104406080

SHAB:

115601234(HSD17B2)

DPUB:

104300852(HSD17B2)

PGUU:

104468180(HSD17B2)

ACAR:

104529221(HSD17B2)

CPEA:

104396360(HSD17B2)

AVIT:

104276875(HSD17B2)

CVF:	104291178(HSD17B2)

RTD:	128909655(HSD17B2)

CUCA:

104059402(HSD17B2)

TEO:	104372565(HSD17B2)

BRHI:

104494747(HSD17B2)

AAM:	106483270(HSD17B2)

AROW:

112963132(HSD17B2)

NPD:	112949904(HSD17B2)

TGT:	104567310(HSD17B2)

DNE:	112978869(HSD17B2)

SCAM:

104149336(HSD17B2)

ASN:	102375872(HSD17B2)

AMJ:	102574309(HSD17B2)

CPOO:

109310653(HSD17B2)

GGN:	109289465(HSD17B2)

PSS:	102453984(HSD17B2)

CMY:	102941631(HSD17B2)

CCAY:

125620723(HSD17B2)

DCC:	119840996(HSD17B2)

CPIC:

101941193(HSD17B2)

TST:	117886839(HSD17B2)

CABI:

116816710(HSD17B2)

MRV:	120384420(HSD17B2)

ASAO:

132783051(HSD17B2)

PVT:	110090097(HSD17B2)

SUND:

121914651(HSD17B2)

PBI:	103058540(HSD17B2)

PMUR:

107287717(HSD17B2)

CTIG:

120312099(HSD17B2)

PGUT:

117670961(HSD17B2)

APRI:

131184233(HSD17B2)

PTEX:

113444995(HSD17B2)

NSS:	113424570(HSD17B2)

VKO:	123022312(HSD17B2)

PMUA:

114602206(HSD17B2)

PRAF:

128419440(HSD17B2)

ZVI:	118087060(HSD17B2)

HCG:	128334597(HSD17B2)

GJA:	107109831(HSD17B2)

EMC:	129343822(HSD17B2)

XLA:	108714085(hsd17b2.L)

XTR:	100497002(hsd17b2)

NPR:	108786564(HSD17B2)

RTEM:

120917949(HSD17B2)

BBUF:

120980090(HSD17B2)

MUO:	115469904(HSD17B2)

GSH:	117359166(HSD17B2)

DRE:	449537(hsd17b2)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122330811(hsd17b2)

LROH:

127156571(hsd17b2)

OMC:	131534314(hsd17b2)

PPRM:

120468188(hsd17b2)

RKG:	130080378(hsd17b2)

MAMB:

125247415(hsd17b2)

CIDE:

127507010

MASI:

127437468

TROS:

130550814(hsd17b2)

TDW:	130413901(hsd17b2)

MANU:

129434373(hsd17b2)

IPU:	108275401(hsd17b2)

IFU:	128617825(hsd17b2)

PHYP:

113529589

SMEO:

124392856(hsd17b2)

TFD:	113659887(hsd17b2)

TVC:	132857549(hsd17b2)

AMEX:

103032973(hsd17b2)

CMAO:

118811626(hsd17b2)

EEE:

113573186

TRU:

101071919

TFS:	130535658(hsd17b2)

LCO:	104938964(hsd17b2)

CGOB:

115005645

ELY:	117262723(hsd17b2)

EFO:	125887122(hsd17b2)

SLUC:

116060807(hsd17b2)

PFLV:

114560137(hsd17b2)

AFB:	129108857(hsd17b2)

MSAM:

119894425(hsd17b2)

SCHU:

122875199(hsd17b2)

ALAT:

119023816(hsd17b2)

AOCE:

111585754

CSEM:

103379612(hsd17b2)

SSEN:

122775401(hsd17b2)

HHIP:

117762652(hsd17b2) 117763120

HSP:	118110216(hsd17b2)

SMAU:

118314758(hsd17b2)

LCF:	108885234(hsd17b2)

SDU:

111233733

SLAL:

111647408

BPEC:

110162637(hsd17b2)

MALB:

109969153(hsd17b2)

BSPL:

114857018(hsd17b2)

SJO:	128359046(hsd17b2)

SASA:

106561531(hsd17b2)

STRU:

115197518(hsd17b2)

OTW:	112218829(hsd17b2)

OMY:	110499264(hsd17b2)

OGO:	124033783(hsd17b2)

ONE:	115133991(hsd17b2)

OKI:	109866803(hsd17b2)

OKE:	118395927(hsd17b2)

SALP:

111962699(hsd17b2)

SNH:	120066711(hsd17b2)

CCLU:

121532165(hsd17b2)

ELS:	105018101(hsd17b2)

LOC:	102692720(hsd17b2)

PSPA:

121325469 121325854

ARUT:

117424683 117425386

PSEX:

120535558(hsd17b2)

LCM:	102360275(HSD17B2)

CMK:

103191276

RTP:	109928139(hsd17b2)

CPLA:

122558269(hsd17b2)

HOC:	132823892(hsd17b2)

LERI:

129705386(hsd17b2)

LRJ:

BFO:

BBEL:

SPU:

LPIC:

APLC:

110977970 110988430 110988439

SKO:	100368354 100374321

NVL:

RMP:

TUT:

DFR:

PTEP:

107436613 107442495 107442496 107450562

ABRU:

UDV:

SDM:

LPOL:

PVUL:

PCAN:

GAE:

HRF:

CRG:	105320727 105342689

CVN:

111113370

CANU:

128178694 128191713

OED:	125681672 125683552

MYI:	110444395 110447833 110457855

PMAX:

MMER:

RPHI:

DPOL:

OBI:	106872799 106879333 106879334

OSN:	115212282 115212360 115213937

LAK:	106154383 106157985

» show all

Reference

PMID:8099587

Authors

Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S

Title

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.

Journal

J Biol Chem 268:12964-9 (1993)

Sequence

[hsa:3294]

Reference

PMID:19022235

Authors

Smuc T, Rizner TL

Title

Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.

Journal

Chem Biol Interact 178:228-33 (2009)
DOI:10.1016/j.cbi.2008.10.038

Reference

PMID:19737616

Authors

Plante J, Simard M, Rantakari P, Cote M, Provost PR, Poutanen M, Tremblay Y

Title

Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant.

Journal

J Steroid Biochem Mol Biol 117:139-45 (2009)
DOI:10.1016/j.jsbmb.2009.08.006

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