KEGG   PATHWAY: csab05415
Entry
csab05415                   Pathway                                
Name
Diabetic cardiomyopathy - Chlorocebus sabaeus (green monkey)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
csab05415  Diabetic cardiomyopathy
csab05415

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103224987  SLC2A1; solute carrier family 2 member 1 [KO:K07299]
103242286  SLC2A4; solute carrier family 2 member 4 [KO:K07191]
103245205  GFPT2; glutamine-fructose-6-phosphate transaminase 2 [KO:K00820] [EC:2.6.1.16]
103220112  GFPT1; glutamine--fructose-6-phosphate transaminase 1 [KO:K00820] [EC:2.6.1.16]
103236144  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
103215984  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
103226136  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
103244792  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
103235292  TNNI3; troponin I3, cardiac type [KO:K12044]
103230821  RYR2; ryanodine receptor 2 [KO:K04962]
103240486  PLN; phospholamban [KO:K05852]
103230269  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
103242172  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
103239106  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
103238395  SP1; Sp1 transcription factor [KO:K04684]
103230737  AGT; angiotensinogen [KO:K09821]
103230256  REN; renin [KO:K01380] [EC:3.4.23.15]
103228741  CMA1; chymase 1 [KO:K01329] [EC:3.4.21.39]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103221709  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
103247465  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103246614  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
103233451  cytochrome b-245 light chain [KO:K08009]
103230452  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
103223257  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103223272  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103241511  AGTR1; angiotensin II receptor type 1 [KO:K04166]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103221595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103221596  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103223551  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103223553  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103233007  MMP2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24]
103245064  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
103242943  COL1A1; collagen type I alpha 1 chain [KO:K06236]
103226536  COL1A2; collagen type I alpha 2 chain [KO:K06236]
103217501  COL3A1; collagen type III alpha 1 chain [KO:K19720]
103234729  TGFB1; transforming growth factor beta 1 [KO:K13375]
103230082  TGFB2; transforming growth factor beta 2 [KO:K13376]
103229367  TGFB3; transforming growth factor beta 3 [KO:K13377]
103226648  CD36; CD36 molecule [KO:K06259]
103223491  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
103223575  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
103226523  PDK4; pyruvate dehydrogenase kinase 4 [KO:K00898] [EC:2.7.11.2]
103242950  PDK2; pyruvate dehydrogenase kinase 2 [KO:K00898] [EC:2.7.11.2]
103231727  PDK3; pyruvate dehydrogenase kinase 3 [KO:K00898] [EC:2.7.11.2]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103227755  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
103239776  PTPA; protein phosphatase 2 phosphatase activator [KO:K17605]
103218909  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
103220572  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
103239526  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
103236841  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
103225772  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
103224794  CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
103239029  INS; insulin [KO:K04526]
103234346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103216211  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103235009  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
103218736  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
103214869  TBC1D4; TBC1 domain family member 4 [KO:K17902]
103231815  MPC1L; mitochondrial pyruvate carrier 1-like [KO:K22138]
103240904  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
103230647  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
103231682  PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
103235992  PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
103227812  PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
4097488  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4097489  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4097495  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4097497  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4097496  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4097498  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4097499  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103216555  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
103222752  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
103219478  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103247345  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
103244665  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
103244309  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103235239  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
103226480  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
103244129  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [KO:K03948]
103238561  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
103226813  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
103219870  uncharacterized LOC103219870 [KO:K03949]
103223414  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
103225256  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
103233836  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
103218895  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
103218424  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
103218204  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
103229745  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
103233757  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
103238888  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
103234228  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
103229567  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
103227023  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
103217629  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
103228104  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
103228205  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
103221202  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
103219306  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
103234046  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
103216390  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
103237406  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
103226429  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
103231882  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
103217702  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
103223688  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
103236018  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
103221350  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
103228810  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103236524  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
103214941  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
103233605  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
103215835  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
103236278  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
103248104  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
103215231  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
103215235  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
103225507  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
103223678  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
103225005  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
103216985  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
103240581  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
103248461  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
103234417  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4097500  CYTB; cytochrome b [KO:K00412]
103237609  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103227597  UQCRC1; ubiquinol-cytochrome c reductase core protein I [KO:K00414]
103229564  UQCR2; ubiquinol-cytochrome c reductase core protein II [KO:K00415]
103224893  UQCRH; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
103218927  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
103237165  cytochrome b-c1 complex subunit 7 [KO:K00417]
103244527  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII [KO:K00418]
103223148  UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
103233614  cytochrome b-c1 complex subunit 10 [KO:K00420]
4097494  COX3; cytochrome c oxidase subunit III [KO:K02262]
4097490  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4097491  COX2; cytochrome c oxidase subunit II [KO:K02261]
103233412  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
103248003  COX4I2; cytochrome c oxidase subunit 4I2 [KO:K02263]
103245320  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103241089  COX5B; cytochrome c oxidase subunit 5B [KO:K02265]
103231423  COX6A2; cytochrome c oxidase subunit 6A2 [KO:K02266]
103239250  COX6A1; cytochrome c oxidase subunit 6A1 [KO:K02266]
103242353  uncharacterized protein LOC103242353 [KO:K02267]
103235309  cytochrome c oxidase subunit 6B2 [KO:K02267]
103237200  cytochrome c oxidase subunit 6C [KO:K02268]
103243885  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103220405  COX7A2L; cytochrome c oxidase subunit 7A2 like [KO:K02270]
103246147  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
103232235  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103231597  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
103229590  COX8C; cytochrome c oxidase subunit 8C [KO:K02273]
103222477  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103238538  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
103237855  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
103233597  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
103243426  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
4097493  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103224226  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
103243629  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
103233760  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
103214808  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
103217364  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
103238407  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
103236222  ATP synthase subunit d, mitochondrial [KO:K02138]
103243059  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
103216644  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
103217773  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
4097492  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103244541  VDAC1; voltage dependent anion channel 1 [KO:K05862]
103215964  VDAC2; voltage dependent anion channel 2 [KO:K15040]
103215691  VDAC3; voltage dependent anion channel 3 [KO:K15041]
103236621  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
103236238  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
103247519  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
103247334  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
103220507  ADP/ATP translocase 2-like [KO:K05863]
103215933  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
103235232  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103227233  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
103218453  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103229992  PARP1; poly(ADP-ribose) polymerase 1 [KO:K24070] [EC:2.4.2.30]
103232833  G6PD; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103215584  GSR; glutathione-disulfide reductase [KO:K00383] [EC:1.8.1.7]
103219139  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
103241808  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
103222457  SMAD2; SMAD family member 2 [KO:K04500]
103245436  SMAD3; SMAD family member 3 [KO:K23605]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103243232  angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
103243233  angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
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Related
pathway
csab00010  Glycolysis / Gluconeogenesis
csab00020  Citrate cycle (TCA cycle)
csab00190  Oxidative phosphorylation
csab00520  Amino sugar and nucleotide sugar metabolism
csab03320  PPAR signaling pathway
csab04071  Sphingolipid signaling pathway
csab04150  mTOR signaling pathway
csab04210  Apoptosis
csab04260  Cardiac muscle contraction
csab04350  TGF-beta signaling pathway
csab04614  Renin-angiotensin system
csab04910  Insulin signaling pathway
csab04930  Type II diabetes mellitus
csab04931  Insulin resistance
csab04933  AGE-RAGE signaling pathway in diabetic complications
csab04940  Type I diabetes mellitus
KO pathway
ko05415   
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