KEGG   PATHWAY: mni05415
Entry
mni05415                    Pathway                                
Name
Diabetic cardiomyopathy - Macaca nemestrina (pig-tailed macaque)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mni05415  Diabetic cardiomyopathy
mni05415

Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105494864  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
105473329  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
105465201  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
105483985  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
105486221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5 [KO:K04515] [EC:2.7.11.17]
105466008  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105466870  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105494213  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105496973  TNNI3; troponin I, cardiac muscle [KO:K12044]
105474624  RYR2; ryanodine receptor 2 [KO:K04962]
105465501  PLN; cardiac phospholamban [KO:K05852]
105482864  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105493427  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
105472072  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105474275  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
105499156  AGT; angiotensinogen [KO:K09821]
105484787  REN; renin [KO:K01380] [EC:3.4.23.15]
105477881  CMA1; chymase [KO:K01329] [EC:3.4.21.39]
105485029  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105497586  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
105463247  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105466359  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105488833  cytochrome b-245 light chain [KO:K08009]
105484568  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105464509  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
105497946  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105464493  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105470040  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105486337  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
105469585  RELA; transcription factor p65 isoform X1 [KO:K04735]
105474512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105474514  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105489757  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105489758  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105486663  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105479668  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105484084  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
105494081  MMP2; 72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
105496466  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105475526  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105472370  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
105468239  COL3A1; collagen alpha-1(III) chain [KO:K19720]
105495300  TGFB1; transforming growth factor beta-1 [KO:K13375]
105493507  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105495762  TGFB3; transforming growth factor beta-3 [KO:K13377]
105475387  CD36; platelet glycoprotein 4 [KO:K06259]
105489798  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
105489740  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
105475540  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
105478241  PDK3; pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
105472365  PDK2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
105469029  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105480568  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
105464006  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
105479729  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105469672  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105493733  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105469796  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105496712  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105495080  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
105469786  INS; insulin isoform X1 [KO:K04526]
105487005  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105473988  IRS1; insulin receptor substrate 1 [KO:K16172]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105480917  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105473151  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105470323  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105478667  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105492101  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105481744  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
105487553  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
105499943  MPC1L; LOW QUALITY PROTEIN: mitochondrial pyruvate carrier 1-like protein [KO:K22138]
105492997  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
105464213  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105478195  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105482923  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
105469694  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105478880  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X3 [KO:K03943] [EC:7.1.1.2]
105472574  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105468400  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105467025  NDUFA2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105497018  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X3 [KO:K03947]
105475593  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105474110  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112426545  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112427778  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105475029  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105477409  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
105464351  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105483089  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105487165  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105484157  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
105473801  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
105489133  acyl carrier protein, mitochondrial-like [KO:K03955]
105485022  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105478989  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105484859  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105483684  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105497621  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105467540  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105471277  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
105468110  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112426670  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
105470317  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105489967  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
105485641  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105497061  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105478395  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105468474  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105471449  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like [KO:K03965]
105485828  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105463793  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105483680  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
105468281  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105498205  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105471693  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105499367  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105494775  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105494941  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105463264  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105486180  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105469699  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105493267  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105468808  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105468985  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
105483145  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105498215  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105480281  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
105493055  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
105493610  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105487652  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
105493947  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
105488482  cytochrome c1, heme protein, mitochondrial [KO:K00413]
105480413  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105484999  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
105487134  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
105494962  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
105476105  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
105467163  cytochrome b-c1 complex subunit 8 [KO:K00418]
105487255  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
105486029  cytochrome b-c1 complex subunit 10 [KO:K00420]
105476209  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
105496160  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
105496797  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
105490971  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105473724  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
105490054  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105472894  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105482967  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105494743  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105473956  cytochrome c oxidase subunit 6B1 [KO:K02267]
105488177  cytochrome c oxidase subunit 6B2 [KO:K02267]
105476076  cytochrome c oxidase subunit 6C [KO:K02268]
112427459  cytochrome c oxidase subunit 6C-like [KO:K02268]
105464914  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
105479441  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105495477  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
105464285  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
105487680  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105471304  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
105478123  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112423181  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112423470  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112423489  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
105475022  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112426783  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112426926  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112427042  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
105488184  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
105467520  uncharacterized protein LOC105467520 isoform X1 [KO:K02273]
105469497  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105499588  ATP5F1A; LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial [KO:K02132]
105474375  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105494347  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105486269  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105470572  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105463398  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
105479212  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105474261  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105483201  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105472333  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105469147  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105472691  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105472806  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105467147  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105465993  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105476522  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105486103  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105478053  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105466570  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105468552  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105465954  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
105497021  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105474900  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105484185  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X2 [KO:K00134] [EC:1.2.1.12]
105478612  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
105467964  G6PD; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105481963  GSR; LOW QUALITY PROTEIN: glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
105477209  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105470963  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105489370  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105488126  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105469511  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105481530  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105481533  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105492354  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105483045  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
105483150  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
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Related
pathway
mni00010  Glycolysis / Gluconeogenesis
mni00020  Citrate cycle (TCA cycle)
mni00190  Oxidative phosphorylation
mni00520  Amino sugar and nucleotide sugar metabolism
mni03320  PPAR signaling pathway
mni04071  Sphingolipid signaling pathway
mni04150  mTOR signaling pathway
mni04210  Apoptosis
mni04260  Cardiac muscle contraction
mni04350  TGF-beta signaling pathway
mni04614  Renin-angiotensin system
mni04910  Insulin signaling pathway
mni04930  Type II diabetes mellitus
mni04931  Insulin resistance
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04940  Type I diabetes mellitus
KO pathway
ko05415   
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