KEGG    Network variation - Human T-cell leukemia virus 1 (HTLV-1)
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ENTRYnt06160
NameHuman T-cell leukemia virus 1 (HTLV-1)
CategoryDisease view; Viral infection
Pathwayhsa05166 Human T-cell leukemia virus 1 infection
GenomeT40003
DiseaseH00009 Adult T-cell leukemia
Display drug-target relation   disease type
PI3K signaling
N00390    EGFEGFRPI3KPIP3AKTIKKNFKBIANFKB
N00501      TAXPI3K
N00220        PTENPIP3AKT
N00502    TAXDLG1PTEN
 
TGFB signaling
N00063    TGFB(TGFBR2+TGFBR1)(SMAD2,SMAD3)=SMAD4
N00507      TAX(SMAD2,SMAD3)
 
JAK-STAT signaling
N00053    CytokineReceptorJAKSTATPIM1
N00491    P12IL2RB/GJAK1/3STAT5IL2
 
Calcium signaling
N00487    IGH(LYN,SYK)(BTK,BLNK)PLCG2IP3Ca2+CALM=CNNFAT
N00490          P12=(CALR,CANX)Ca2+
 
TNF signaling
N00446    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK4/7JNKAP1
N00503            TAX(MAPK8,MAPK9,MAPK1..JUNMMP7
N00151    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00504        TAXIKKNFKBIANFKB
N00505    CD40LGCD40(TRAF2+TRAF3)NIKIKKA(NFKB2+RELB)
N00506        TAX=IKBKGIKKA(NFKB2+RELB)
 
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00492        P12(MHCI+B2M)
 
Cell cycle
N00069          CDKN2A(CCND+CDK4/6)RB1E2F
N00494        TAXCDKN2A
N00090      (MYC+MAX)ZBTB17CDKN2B(CCND+CDK4/6)RB1E2F
N00495        TAXCDKN2B
N00499    (ATM,ATR)CHEK1TP53CDKN1A(CDK1+CCNB)
N00500    TAXCHEK1
N00493      MAD1L1(MAD2L1/2+BUB1B+BU..(ANAPC+CDC20)PTTGESPL1
N00222    TAXMAD1L1
N00221        TAX(ANAPC+CDC20)PTTGESPL1
 
Transcription
N00489    P30II(MYC+TRRAP+KAT5)CCND2
N00497      TAXTP53CDKN1A(CDK2+CCNE)RB1E2F
N00498        TAXCDKN1A(CDK2+CCNE)RB1E2F
N00508    TAXNFYBMHCII
N00509    TAXSRF(FOS,FOSL1,EGR1,EG..
N00510    TAXCREB3CCND1
N00511    TAXE47(POLB,LCK,BAX,CDKN..
N00512    TAXMYCTERT