KEGG ORTHOLOGY: K02330

ORTHOLOGY: K02330

Entry

K02330                      KO

Symbol

POLB

Name

DNA polymerase beta [EC:2.7.7.7 4.2.99.-]

Pathway

map03410

Base excision repair

map05166

Human T-cell leukemia virus 1 infection

map05203

Viral carcinogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    K02330  POLB; DNA polymerase beta
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K02330  POLB; DNA polymerase beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02330  POLB; DNA polymerase beta
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K02330  POLB; DNA polymerase beta
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     K02330  POLB; DNA polymerase beta
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Short Patch-BER factors
     K02330  POLB; DNA polymerase beta
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     K02330  POLB; DNA polymerase beta
DNA polymerases [br01612.html]
DNA polymerases in prokaryotes, eukaryotes and viruses
  K02330

Other DBs

GO:

0003887

Genes

HSA:	5423(POLB)

PTR:	737210(POLB)

PPS:	100990190(POLB)

GGO:	101144130(POLB)

PON:	100441812(POLB)

NLE:	100588738(POLB)

HMH:	116461830(POLB)

MCC:	704801(POLB)

MCF:	102115303(POLB)

MTHB:

126960765

MNI:	105476526(POLB)

CSAB:

103215689(POLB)

CATY:

105595758(POLB)

PANU:

101018348(POLB)

TGE:	112630463(POLB)

MLEU:

105554915

RRO:	104666045(POLB)

RBB:	108540714(POLB)

TFN:	117095663(POLB)

PTEH:

111527699(POLB)

CANG:

105525124(POLB)

CJC:	100393825(POLB)

SBQ:	101046175(POLB)

CIMI:

108316187(POLB)

CSYR:

103257265(POLB)

MMUR:

105878145(POLB)

LCAT:

123626608(POLB)

PCOQ:

105819664(POLB)

OGA:	100945851(POLB)

MMU:	18970(Polb)

MCAL:

110300157(Polb)

MPAH:

110336444(Polb)

RNO:	29240(Polb)

MCOC:

116069015(Polb)

ANU:	117721999(Polb)

MUN:	110556619(Polb)

CGE:	100774965(Polb)

MAUA:

101834160(Polb)

PROB:

127220321(Polb)

PLEU:

114705742(Polb)

MORG:

121462242(Polb)

MFOT:

126504412

AAMP:

119811855(Polb)

NGI:	103726620(Polb)

HGL:	101710722(Polb)

CPOC:

100731356(Polb)

CCAN:

109696397(Polb)

DORD:

105991849(Polb)

DSP:	122107640(Polb)

PLOP:

125339359(Polb) 125363317

NCAR:

124983891

MMMA:

107159645(Polb)

OCU:

100348691

OPI:	101516772(POLB)

TUP:	102502435(POLB)

GVR:	103589265(POLB)

CFA:	494001(POLB)

CLUD:

112656224(POLB)

VVP:	112916158(POLB)

VLG:	121490081(POLB)

NPO:	129516045(POLB)

AML:	100471432(POLB)

UMR:	103677058(POLB)

UAH:	113245572(POLB)

UAR:	123780308(POLB)

ELK:

111144449

LLV:

125092798

MPUF:

101687228(POLB)

MNP:	132006385(POLB)

MLK:	131820449(POLB)

NVS:	122889855(POLB)

ORO:	101375051(POLB)

EJU:	114224843(POLB)

ZCA:	113925660(POLB)

MLX:	118009920(POLB)

NSU:	110573112(POLB)

LWW:	102751059(POLB)

FCA:	101099797(POLB)

PYU:	121012769(POLB)

PCOO:

112858042(POLB)

PBG:	122472992(POLB)

PVIV:

125164273(POLB)

LRUF:

124520494

PTG:	102963455(POLB)

PPAD:

109262263(POLB)

PUC:

125923309

AJU:

106990013

HHV:	120234026(POLB)

BTA:	614688(POLB)

BOM:	102281166(POLB)

BIU:	109553520(POLB)

BBUB:

102399213(POLB)

BBIS:

104993224(POLB)

CHX:	102177689(POLB)

OAS:	101122327(POLB)

BTAX:

128068217(POLB)

ODA:	120865851(POLB)

CCAD:

122432634(POLB)

MBEZ:

129549431(POLB)

SSC:	100526021(POLB)

CFR:	102508539(POLB)

CBAI:

105071235(POLB)

CDK:	105086432(POLB)

VPC:	102528573(POLB)

BACU:

103013074(POLB)

BMUS:

118887918(POLB)

LVE:	103088370(POLB)

OOR:	101286165(POLB)

DLE:	111173554(POLB)

PCAD:

102976221(POLB) 102983345

PSIU:

116746849(POLB)

NASI:

112413118(POLB)

ECB:	100050102(POLB)

EPZ:	103540388(POLB)

EAI:	106828958(POLB)

MYB:	102254615(POLB)

MYD:	102773539(POLB)

MMYO:

118650233(POLB)

MLF:	102443223(POLB)

PKL:	118728484(POLB)

EFUS:

103288181(POLB)

MNA:	107523911(POLB)

DRO:	112321484(POLB)

SHON:

118993209(POLB)

AJM:	119047139(POLB)

PDIC:

114508909(POLB)

PHAS:

123807739(POLB)

MMF:	118622846(POLB)

PPAM:

129064789(POLB)

HAI:	109386265(POLB)

RFQ:	117021735(POLB)

PALE:

102893018(POLB)

PGIG:

120595666(POLB)

PVP:	105300524(POLB)

RAY:	107501354(POLB)

MJV:	108399798(POLB)

TOD:	119257854(POLB)

SARA:

101540208(POLB)

SETR:

126006489(POLB) 126006741

LAV:	100657074(POLB)

TMU:

101351696

ETF:	101657073 101657318(POLB)

DNM:	101412249(POLB)

MDO:	100030148(POLB)

GAS:	123236978(POLB)

SHR:	100929187(POLB)

AFZ:

127548273

PCW:	110196424(POLB)

OAA:	100078894(POLB)

GGA:	426794(POLB)

PCOC:

116234506(POLB)

MGP:	100549334(POLB)

CJO:	107323743(POLB)

TPAI:

128071874(POLB)

LMUT:

125685343(POLB)

NMEL:

110387128(POLB)

APLA:

101792343(POLB)

ACYG:

106044369(POLB)

CATA:

118256063(POLB)

TGU:	100221830(POLB) 116807235

LSR:	110473411(POLB)

SCAN:

103822677(POLB)

PMOA:

120505708(POLB)

OTC:	121346779(POLB)

PRUF:

121359409(POLB)

GFR:	102035476(POLB)

FAB:	101818872(POLB)

OMA:	130261959(POLB)

PHI:	102100382(POLB)

PMAJ:

107213915(POLB)

CCAE:

111938869(POLB)

CCW:	104694917(POLB)

CBRC:

103615491(POLB)

ETL:	114066444(POLB)

ZAB:	102073960(POLB)

ZLE:	135456966(POLB)

ACHL:

103797715(POLB)

SVG:	106862059(POLB)

MMEA:

130584485(POLB)

HRT:	120764069(POLB)

FPG:	101922234(POLB)

FCH:	102058720(POLB)

CLV:	102087419(POLB)

EGZ:	104135297(POLB)

NNI:	104017588(POLB)

PCRI:

104031018(POLB)

PLET:

104618238(POLB)

EHS:	104512716(POLB)

PCAO:

104039845(POLB)

ACUN:

113488091(POLB)

TALA:

104363898(POLB)

PADL:

103920553(POLB)

AFOR:

103901098(POLB)

ACHC:

115350504(POLB)

HALD:

104310864(POLB)

HLE:	104828790(POLB)

AGEN:

126051574

GCL:

127025237

CCRI:

104157901(POLB)

CSTI:

104549567(POLB)

CMAC:

104473790(POLB)

MUI:	104548495(POLB)

BREG:

104629882(POLB)

FGA:	104070068(POLB)

GSTE:

104250639(POLB)

LDI:	104352795(POLB)

MNB:	103775045(POLB)

OHA:	104333226(POLB)

NNT:	104399517(POLB)

SHAB:

115618531(POLB)

DPUB:

104301260(POLB)

PGUU:

104464057(POLB)

ACAR:

104531190(POLB)

CPEA:

104384892(POLB)

AVIT:

104267484(POLB)

CVF:	104285156(POLB)

RTD:	128919571(POLB)

TEO:	104377193(POLB)

BRHI:

104500943(POLB)

AAM:	106487777(POLB)

AROW:

112974189(POLB)

NPD:	112953872(POLB)

TGT:	104568895(POLB)

DNE:	112990466(POLB)

SCAM:

104148774(POLB)

ASN:	102377806(POLB)

AMJ:	102561879(POLB)

CPOO:

109317386(POLB)

PSS:	102449407(POLB)

CMY:	102931250(POLB)

CCAY:

125626300(POLB)

DCC:	119848742(POLB)

CPIC:

101946448(POLB)

TST:	117873056(POLB)

CABI:

116819038(POLB)

MRV:	120397040(POLB)

ACS:	100552750(polb)

ASAO:

132782330(POLB)

PVT:	110072081(POLB)

SUND:

121915607 121933179

PBI:	103066680(POLB)

PMUR:

107283271(POLB)

CTIG:

120299417(POLB)

TSR:	106556881(POLB)

PGUT:

117673369(POLB)

APRI:

131203629(POLB)

PTEX:

113445818(POLB)

NSS:	113423362(POLB)

VKO:	123016753(POLB)

PMUA:

114602662(POLB)

PRAF:

128420043(POLB)

ZVI:	118086700(POLB)

HCG:	128333518(POLB)

GJA:	107120337(POLB)

STOW:

125442064(POLB)

EMC:	129342645(POLB)

XLA:	397973(polb.S)

XTR:	448741(polb)

NPR:	108791449(POLB)

RTEM:

120933166(POLB)

BBUF:

120986315(POLB)

MUO:	115469434(POLB)

GSH:	117362672(POLB)

DRE:	554204(polb)

SRX:	107722860 107754421(polb)

SANH:

107670984 107699674

SGH:	107559597(polb) 107560038

CCAR:

109095155 109095156

CAUA:

113052780 113106966

CGIB:

127962955 128019054

PTET:

122350414(polb)

LROH:

127170242(polb)

OMC:	131545295(polb)

PPRM:

120489011(polb)

MAMB:

125280160(polb)

CIDE:

127517687

MASI:

127415140 127424479

TROS:

130568021(polb)

TDW:	130440138(polb)

MANU:

129413993(polb)

IPU:

108265244

IFU:	128607715(polb)

PHYP:

113533573(polb)

SMEO:

124400382(polb)

TFD:	113656144(polb)

TVC:	132853633(polb)

TRN:	134318103(polb)

AMEX:

103039401(polb)

CMAO:

118813510(polb)

EEE:	113590680(polb)

CHAR:

105898462(polb)

TRU:	101062869(polb)

TFS:	130526098(polb)

TNG:	GSTEN00029575G001

LCO:	104921658(polb)

NCC:	104950379 104956689(polb)

TBEN:

117473113(polb)

CGOB:

115013994(polb)

PGEO:

117452684(polb)

GACU:

117560525(polb)

EMAC:

134874082(polb)

ELY:	117253213(polb)

EFO:	125890624(polb)

PLEP:

121944286(polb)

SLUC:

116054228(polb)

ECRA:

117945499(polb)

ESP:	116689743(polb)

PFLV:

114555636(polb)

GAT:	120831085(polb)

PPUG:

119225538(polb)

AFB:	129101254(polb)

CLUM:

117736633(polb)

PSWI:

130197000(polb)

MSAM:

119891195(polb)

SCHU:

122875694(polb)

CUD:	121510528(polb)

ALAT:

119019042(polb)

MZE:	101474836(polb)

ONL:	100698602(polb)

OAU:	116311013(polb)

OLA:	101171171(polb)

OML:	112148076(polb)

CSAI:

133450693(polb)

XMA:	102224288(polb)

XCO:	114155080(polb)

XHE:	116730285(polb)

PRET:

103470029(polb)

PFOR:

103145831(polb)

PLAI:

106956811(polb)

PMEI:

106921747(polb)

GAF:	122826512(polb)

PPRL:

129366264(polb)

CVG:	107089643(polb)

CTUL:

119778141(polb)

GMU:	124877229(polb)

NFU:	107394256(polb)

KMR:	108233710(polb)

ALIM:

106519926(polb)

NWH:	119413236(polb)

AOCE:

111577272(polb)

MCEP:

125011708(polB)

CSEM:

103397767 103399031

POV:	109637055(polb)

SSEN:

122770180(polb)

HHIP:

117767719(polb)

HSP:	118115433(polb)

PPLT:

128437988(polb)

SMAU:

118313447(polb)

LCF:

108881626

SDU:	111236500(polb)

SLAL:

111665989(polb)

XGL:	120805089(polb)

HCQ:	109526786(polb)

SSCV:

125994146

SBIA:

133499844(polb)

PEE:	133399973(polb)

PTAO:

133475139(polb)

BPEC:

110153402(polb)

MALB:

109956493(polb)

BSPL:

114861866(polb)

SJO:	128364533(polb)

SASA:

106580473 106585055(polb)

STRU:

115164355(polb)

OTW:

112248603

OMY:

110525813

OGO:

124034208

ONE:	115111719(polb)

OKI:	109881352(polb)

OKE:	118393340(polb)

SALP:

111974593(polb)

SNH:	120032871(polb)

CCLU:

121573262 121584977(polb)

ELS:	105014301(polb)

SFM:	108920118(polb)

PKI:	111854376(polb)

AANG:

118212265 118237583(polb)

LOC:	102698669(polb)

PSPA:

121302391 121303203

ARUT:

117397685(polb)

PSEX:

120538745(polb)

LCM:	102356930(POLB)

CMK:	103191220(polb)

RTP:	109927978(polb)

CPLA:

122543169(polb)

HOC:	132836871(polb)

LERI:

129713384(polb)

PMRN:

116946577(POLB)

LRJ:	133346402(POLB)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

CFO:

FEX:

LHU:

PGC:

OBO:	105274688 105275157

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

DAM:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:	111414498 111414803

DPL:	KGM_208467

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

OFU:

ATRA:

PXY:

PGW:

LGLY:

API:

DNX:

AGS:

RMD:

ACOO:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111043444 111051738

HVI:	124353086 124372526

PHU:	Phum_PHUM131800

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

DFR:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_184959

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:	110451511 110466324

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_50243

AQU:

100639771

OLU:	OSTLU_34689

CNE:

CNA04063

CNB:

CNBA3870

CNG:	CNAG_00419 CNAG_02160

TMS:	TREMEDRAFT_25387

SHS:	STEHIDRAFT_66344

HIR:	HETIRDRAFT_444950

PSQ:	PUNSTDRAFT_141226

FME:	FOMMEDRAFT_162427

GTR:	GLOTRDRAFT_139007 GLOTRDRAFT_41174

LBC:	LACBIDRAFT_309120 LACBIDRAFT_319109

CCI:	CC1G_00661

MPR:	MPER_08770 MPER_12749

MRR:	Moror_13798

E1B28_012121

CPUT:

CONPUDRAFT_132911

SLA:	SERLADRAFT_393026

UMA:	UMAG_01262

MBR:	MONBRDRAFT_33482

SRE:	PTSG_03490

DDI:	DDB_G0284713(polB) DDB_G0284739(gxcFF)

DPP:	DICPUDRAFT_152605 DICPUDRAFT_33968

DFA:	DFA_04253(gxcFF)

ACAN:

ACA1_244870

SPAR:

SPRG_19502

EHX:	EMIHUDRAFT_125483 EMIHUDRAFT_201154

TBR:	Tb927.5.2780 Tb927.5.2790

TBG:	TbgDal_V3920 TbgDal_V3950

TCR:	503955.20 507063.100 507063.90

LMA:	LMJF_08_0890 LMJF_08_0900

LIF:	LINJ_08_0830 LINJ_08_0840

LDO:	LDBPK_080830 LDBPK_080840

LMI:	LMXM_08_0890 LMXM_08_0900

LBZ:	LBRM_08_0710 LBRM_08_0720

LPAN:

LPMP_080750 LPMP_080760

» show all

Reference

PMID:11805079

Authors

DeMott MS, Beyret E, Wong D, Bales BC, Hwang JT, Greenberg MM, Demple B

Title

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.

Journal

J Biol Chem 277:7637-40 (2002)
DOI:10.1074/jbc.C100577200

Sequence

[hsa:5423]

Reference

PMID:3182828

Authors

Widen SG, Kedar P, Wilson SH

Title

Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter.

Journal

J Biol Chem 263:16992-8 (1988)

Sequence

[hsa:5423]

LinkDB

DBGET integrated database retrieval system