KEGG ORTHOLOGY: K11407

ORTHOLOGY: K11407

Entry

K11407                      KO

Symbol

HDAC6

Name

histone deacetylase 6 [EC:3.5.1.98]

Pathway

map04613

Neutrophil extracellular trap formation

map05014

Amyotrophic lateral sclerosis

map05034

Alcoholism

map05203

Viral carcinogenesis

Disease

H02260

Chondrodysplasia Chassaing-Lacombe type

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K11407  HDAC6; histone deacetylase 6
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K11407  HDAC6; histone deacetylase 6
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K11407  HDAC6; histone deacetylase 6
  09165 Substance dependence
   05034 Alcoholism
    K11407  HDAC6; histone deacetylase 6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K11407  HDAC6; histone deacetylase 6
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K11407  HDAC6; histone deacetylase 6
   04131 Membrane trafficking
    K11407  HDAC6; histone deacetylase 6
   03036 Chromosome and associated proteins
    K11407  HDAC6; histone deacetylase 6
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     K11407  HDAC6; histone deacetylase 6
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K11407  HDAC6; histone deacetylase 6
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K11407  HDAC6; histone deacetylase 6
Membrane trafficking [BR:ko04131]
Autophagy
  Aggrephagy
   Other aggrephagy associated proteins
    K11407  HDAC6; histone deacetylase 6
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class II HDACs
     K11407  HDAC6; histone deacetylase 6

Other DBs

GO:

0004407

Genes

HSA:	10013(HDAC6)

PTR:	100610515(HDAC6)

PPS:	100979180(HDAC6)

GGO:	101148332(HDAC6)

PON:	100459509(HDAC6)

NLE:	100589125(HDAC6)

HMH:	116811664(HDAC6)

MCC:	711363(HDAC6)

MCF:	101926822(HDAC6)

MTHB:

126945539

MNI:

105493906

CSAB:

103231941(HDAC6)

CATY:

105573127(HDAC6)

PANU:

101009309(HDAC6)

TGE:	112613154 112616386(HDAC6)

MLEU:

105547721(HDAC6)

RRO:	104660656(HDAC6)

RBB:	108517465(HDAC6)

TFN:	117077325(HDAC6)

PTEH:

111535713(HDAC6)

CANG:

105515009(HDAC6)

CJC:	100414028(HDAC6)

SBQ:	101053695(HDAC6)

CIMI:

108300901(HDAC6)

CSYR:

103268713(HDAC6)

MMUR:

105856366(HDAC6)

LCAT:

123628370(HDAC6)

PCOQ:

105816839(HDAC6)

OGA:	100948764(HDAC6)

MMU:	15185(Hdac6)

MCAL:

110286792(Hdac6)

MPAH:

110313282(Hdac6)

RNO:	108348065(Hdac6)

MCOC:

116067979(Hdac6)

ANU:	117694531(Hdac6) 117694578

MUN:	110561985(Hdac6)

CGE:	100763688(Hdac6)

MAUA:

101837825(Hdac6)

PROB:

127218541(Hdac6)

PLEU:

114701304(Hdac6)

MORG:

121442580 121442644

MFOT:

126512866

AAMP:

119804859(Hdac6)

NGI:	103741648(Hdac6)

HGL:	101708442(Hdac6)

CPOC:

100717988(Hdac6)

CCAN:

109692146(Hdac6)

DORD:

105997816(Hdac6) 105997827

DSP:	122098772(Hdac6)

PLOP:

125343330(Hdac6)

NCAR:

124972407

MMMA:

107159831(Hdac6)

OCU:	100354982 103345620

OPI:	101517990(HDAC6)

TUP:	102487728(HDAC6)

GVR:	103589447(HDAC6)

CFA:	480907(HDAC6)

CLUD:

112673134(HDAC6)

VVP:	112907213(HDAC6)

VLG:	121482955(HDAC6)

NPO:	129518404(HDAC6)

AML:	100478725(HDAC6)

UMR:	103668837(HDAC6)

UAH:	113265929(HDAC6)

UAR:	123790885(HDAC6)

ELK:

111150520

LLV:

125091744

MPUF:

101675514(HDAC6)

MNP:	132007732(HDAC6)

MLK:	131820760(HDAC6)

NVS:	122896394(HDAC6)

ORO:	101372755(HDAC6)

EJU:	114216779(HDAC6)

ZCA:	113931350(HDAC6)

MLX:	118010082(HDAC6)

LWW:

102744644

FCA:	101084086(HDAC6)

PYU:	121026129(HDAC6)

PCOO:

112870931(HDAC6)

PBG:	122476850(HDAC6)

PVIV:

125157128(HDAC6)

LRUF:

124509514

PTG:	102950287(HDAC6)

PPAD:

109248075(HDAC6)

PUC:

125931286

AJU:

106989010

HHV:	120221025(HDAC6)

BTA:	513602(HDAC6)

BOM:	102270629(HDAC6)

BIU:	109555290(HDAC6)

BBUB:

102397989(HDAC6)

BBIS:

104991762(HDAC6)

CHX:	102183307(HDAC6)

OAS:	101109245(HDAC6)

BTAX:

128069371(HDAC6)

ODA:	120882100(HDAC6)

CCAD:

122434490(HDAC6)

MBEZ:

129564329(HDAC6)

SSC:	100621798(HDAC6)

CFR:	102507599(HDAC6)

CBAI:

105079395(HDAC6)

CDK:	105103305(HDAC6)

VPC:	102534539(HDAC6)

BACU:

103007075(HDAC6)

BMUS:

118888847(HDAC6)

LVE:	103074668(HDAC6)

OOR:	101279254(HDAC6)

DLE:	111169522(HDAC6)

PCAD:

102977311(HDAC6)

PSIU:

116747492(HDAC6)

NASI:

112416013(HDAC6)

ECB:	100062208(HDAC6)

EAI:	106826974(HDAC6)

MYB:	102261327(HDAC6)

MYD:	102764898(HDAC6)

MMYO:

118654215(HDAC6)

MLF:	102426310(HDAC6)

PKL:	118731748(HDAC6)

EFUS:

103301287(HDAC6)

MNA:	107541374(HDAC6)

DRO:	112322477(HDAC6)

SHON:

118998322(HDAC6)

AJM:	119059773(HDAC6)

PDIC:

114504629(HDAC6)

PHAS:

123832758(HDAC6)

MMF:	118635893(HDAC6)

PPAM:

129065216(HDAC6)

HAI:	109374787(HDAC6)

RFQ:	117026183(HDAC6)

PALE:

102887872(HDAC6)

PGIG:

120587086(HDAC6)

PVP:	105310009(HDAC6)

RAY:	107515022(HDAC6)

MJV:	108404036(HDAC6)

TOD:	119246173(HDAC6)

SARA:

101543916(HDAC6)

LAV:	100677211(HDAC6)

TMU:

101347918

ETF:	101637889(HDAC6)

DNM:

101417909

MDO:	100018936(HDAC6)

GAS:	123253924(HDAC6)

SHR:	100930397(HDAC6)

AFZ:

127542451

OAA:	100090183(HDAC6)

OMA:	130266102(HDAC6)

CMY:	102933682(HDAC6)

CCAY:

125628269(HDAC6)

DCC:	119847506(HDAC6)

CPIC:

101932281(HDAC6)

CABI:

116823950(HDAC6)

MRV:	120388511(HDAC6)

ACS:	100560628(hdac6)

ASAO:

132767815(HDAC6)

PVT:	110090616(HDAC6)

SUND:

121921312(HDAC6)

PBI:	103061412(HDAC6)

PMUR:

107286558(HDAC6)

CTIG:

120299540(HDAC6)

PGUT:

117675445(HDAC6)

APRI:

131191473(HDAC6)

PTEX:

113443287(HDAC6)

NSS:	113417758(HDAC6)

VKO:	123030118(HDAC6)

PMUA:

114588179(HDAC6)

PRAF:

128405473(HDAC6)

ZVI:	118097857(HDAC6)

HCG:	128344157(HDAC6)

STOW:

125429340(HDAC6)

EMC:	129346177(HDAC6)

XLA:	380178(hdac6.L)

XTR:	100379853(hdac6)

NPR:	108788253(HDAC6)

RTEM:

120914088(HDAC6)

BBUF:

121009459(HDAC6)

BGAR:

122919862(HDAC6)

MUO:	115463434(HDAC6)

GSH:	117349987(HDAC6)

DRE:	565482(hdac6)

SRX:	107727426 107743106

SANH:

107674364 107701824

SGH:	107552211 107584872

CCAR:

109055290

CAUA:

113080119 113081328 113107032

CGIB:

127963520 128018969

PTET:

122350987(hdac6)

LROH:

127170165(hdac6)

OMC:	131545252(hdac6)

PPRM:

120474946(hdac6)

RKG:	130099535(hdac6)

MAMB:

125279926(hdac6)

CIDE:

127517056

MASI:

127415013

TROS:

130568550(hdac6)

TDW:	130407274(hdac6)

MANU:

129414482(hdac6)

IPU:

108265870

IFU:	128608190(hdac6)

PHYP:

113535334(hdac6)

SMEO:

124399650(hdac6)

TFD:	113645698(hdac6)

TVC:	132853459(hdac6)

TRN:	134318481(hdac6)

AMEX:

103045033(hdac6)

CMAO:

118813880(hdac6)

EEE:	113575860(hdac6)

CHAR:

105899069(hdac6)

TRU:	101079879(hdac6)

TFS:	130530288(hdac6)

TNG:	GSTEN00001631G001

LCO:	104939299(hdac6)

TBEN:

117478535(hdac6)

PGEO:

117449156(hdac6)

EMAC:

134867313(hdac6)

ELY:	117258305(hdac6)

EFO:	125891568(hdac6)

SLUC:

116045497(hdac6)

PFLV:

114559246(hdac6)

PPUG:

119223205(hdac6)

AFB:	129099750(hdac6)

CLUM:

117733028(hdac6)

PSWI:

130203047(hdac6)

MSAM:

119905517(hdac6)

SCHU:

122883078(hdac6)

CUD:	121517519(hdac6)

ALAT:

119023064(hdac6)

MZE:	101478640(hdac6)

ONL:	100705804(hdac6)

OAU:	116335457(hdac6)

OLA:	101163380(hdac6)

OML:	112158901(hdac6)

CSAI:

133456962(hdac6)

XMA:	102236214(hdac6)

XCO:	114141131(hdac6)

XHE:	116722788(hdac6)

PRET:

103460243(hdac6)

PFOR:

103130750(hdac6)

PLAI:

106940063(hdac6)

PMEI:

106910849(hdac6)

GAF:	122841265(hdac6)

PPRL:

129352934(hdac6) 129354452

CVG:	107099804(hdac6)

CTUL:

119792008(hdac6)

GMU:	124868455(hdac6)

NFU:	107391463(hdac6)

AOCE:

111585596(hdac6)

MCEP:

125008491(hdac6)

CSEM:

103384397(hdac6)

POV:	109645851(hdac6)

SSEN:

122776869(hdac6)

HHIP:

117765227(hdac6)

HSP:	118111194(hdac6)

PPLT:

128441801(hdac6)

SMAU:

118316447(hdac6)

LCF:

108890566

SDU:	111235420(hdac6)

SLAL:

111654966(hdac6)

XGL:	120803633(hdac6)

HCQ:	109510379(hdac6)

SSCV:

125987837

SBIA:

133511345(hdac6)

PEE:	133407305(hdac6)

PTAO:

133485256(hdac6)

BPEC:

110154455(hdac6)

BSPL:

114858611(hdac6)

SJO:	128357828(hdac6)

SASA:

106572925(hdac6)

STRU:

115165283(hdac6)

OTW:	112237498(hdac6)

OMY:	110532843(hdac6)

OGO:	124032401(hdac6)

ONE:

115117051

OKI:

109884314

OKE:	118377351(hdac6)

SNH:

120059565

CCLU:

121587380(hdac6)

ELS:	105028329(hdac6)

SFM:	108934846(hdac6)

PKI:	111856134(hdac6)

AANG:

118207866(hdac6)

LOC:	102682413(hdac6)

PSPA:

121305482(hdac6)

ARUT:

117401801(hdac6)

PSEX:

120543229(hdac6)

LCM:	102361123(HDAC6)

PMRN:

116949292(HDAC6)

LRJ:	133342697(HDAC6)

BFO:

BBEL:

SCLV:

SPU:

AJC:

DME:	Dmel_CG6170(HDAC6)

DER:

6550717

DSE:

6620364

DSI:	Dsimw501_GD17207(Dsim_HDAC6)

DYA:	Dyak_GE17180

DAN:

DSR:

DPO:

DPE:

DMN:	108158734 117187119

DWI:

6641442

DGR:

6569456

DMO:	Dmoj_GI15174

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101900790 131800432

SCAC:

106087653

LCQ:

111679691

LSQ:

119599641

GFS:	119633044 119636042

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ012311

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

SOY:

AGRG:

CSET:

AGB:

LDC:

DVV:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

DPL:	KGM_215725

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PGW:

LGLY:

CCRN:

API:

ACOO:

DVT:	126899929 126904368

BTAB:

109044245

DCI:	103513419 103516239

CLEC:

106670388

HHAL:

106677478

NLU:	111046102 120349123

HVI:

124363302

MQU:	128988629 128988998

PHU:	Phum_PHUM538580

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_194595(HDA6)

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

MNZ:	135204972 135205071

EAF:

111712264

LSM:	121114797 121121333

TCF:

PPOI:

DSV:

RSAN:

RMP:

DFR:

ABRU:

UDV:	129220977 129233886

LPOL:

106457086

PMEO:

129586521 129599368

CEL:	CELE_F41H10.6(hda-6)

CBR:	CBG_19959(Cbr-hdac-6)

CRQ:	GCK72_013543

SMM:	Smp_138780

HMG:

100214986

TAD:	TRIADDRAFT_56890

ATH:	AT5G61070(HDA18)

EGT:

105973287

OSA:

4342472

DOSA:

Os07t0164100-01(Os07g0164100)

OBR:

OGL:

BDI:

ATS:

TDC:	119299409 119307570

TAES:

123102365 123119551 780627

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

OLU:	OSTLU_87707(HDA3505)

SCE:	YNL021W(HDA1)

SEUB:

DI49_4716

SPAO:

SPAR_N02850

AGO:	AGOS_ADL216C

ERC:

Ecym_3324

KLA:	KLLA0_E08383g

KMX:	KLMA_80132(HDA1)

LTH:	KLTH0G10340g

VPO:	Kpol_1039p32

ZRO:	ZYRO0A01870g

CGR:	CAGL0J03454g

NCS:	NCAS_0G03800(NCAS0G03800)

NDI:	NDAI_0G00650(NDAI0G00650)

TPF:	TPHA_0C03390(TPHA0C03390)

TBL:	TBLA_0B06950(TBLA0B06950)

TGB:	HG536_0A02320

TDL:	TDEL_0G02160(TDEL0G02160)

KAF:	KAFR_0H03320(KAFR0H03320)

KNG:	KNAG_0H02010(KNAG0H02010)

ZMK:	HG535_0D02040

PPA:	PAS_chr2-1_0302

DHA:	DEHA2C16918g

PIC:	PICST_71431

PGU:	PGUG_03879

SPAA:

SPAPADRAFT_70543

LEL:	PVL30_000060(HDA1)

CAL:	CAALFM_CR02050CA(HDA1)

CTP:	CTRG_00883

COT:	CORT_0A00760

CDU:	CD36_26960(HDA1)

CTEN:

CANTEDRAFT_118275

YLI:	YALI0E24893g

CLU:	CLUG_04316

CLUS:

A9F13_04g01947

CAUR:

CJI96_0003347

SLB:	AWJ20_1220(HDA1)

PKZ:	C5L36_0C04160

BNN:	FOA43_004128

BBRX:

BRETT_002822

OPA:	HPODL_04853

SLUD:

SCDLUD_002755

NCR:	NCU01525(hda-1)

NTE:	NEUTE1DRAFT147039(NEUTE1DRAFT_147039)

PAN:	PODANSg6332

PBEL:

QC761_305080(HDA1)

PPSD:

QC762_305080(HDA1)

PPSP:

QC763_305080(HDA1)

PPSA:

QC764_305080(HDA1)

TTT:	THITE_75273

MTM:	MYCTH_96869

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_4098

SSCK:

SPSK_00230

FGR:	FGSG_04324

FPU:	FPSE_01499

FPOA:

FPOAC1_006787

FVN:	FVRRES_07410

FVR:	FVEG_11339

FOX:	FOXG_13914

NHE:	NECHADRAFT_106321(HDA2102)

FFC:	NCS54_01058500

FKR:	NCS57_01052300

FMU:	J7337_011793

TRE:	TRIREDRAFT_80797

TRR:	M419DRAFT_26130

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_04922

PTKZ:

JDV02_002655(HDA1)

VDA:	VDAG_00890

CFJ:	CFIO01_10701

CLUP:

CLUP02_00730

CHIG:

CH63R_12688

SAPO:

SAPIO_CDS2815

ELA:	UCREL1_7399

PFY:	PFICI_08988

SSL:	SS1G_07799

BFU:	BCIN_15g02130(Bchda1)

MBE:

MBM_05498

PSCO:

LY89DRAFT_676386

GLZ:	GLAREA_03011

ANI:	ANIA_08042

AFM:	AFUA_5G01980

ACT:	ACLA_003280

NFI:	NFIA_040140

AOR:	AO090003001321

AFV:	AFLA_000356

ALUC:

AKAW2_70150S(HDA1)

ACHE:

ACHE_51081A(HDA1)

APUU:

APUU_41507S(HDA1)

PCS:	N7525_008002

PDP:	PDIP_47880

POU:	POX_a00048

TMF:	EYB26_005171

TRG:	TRUGW13939_02638

CIM:	CIMG_06405

CPW:	CPC735_029070

PBL:	PAAG_08467

PBN:	PADG_02410

BGH:	BDBG_07960

PTE:

PTT_13889

BZE:	COCCADRAFT_82967

BSC:	COCSADRAFT_41143

BOR:	COCMIDRAFT_85978

AALT:

CC77DRAFT_1074936

ARAB:

EKO05_0008747

ZTR:	MYCGRDRAFT_37223(HDA2404)

PFJ:	MYCFIDRAFT_107291

FFU:	CLAFUR5_03119

CBET:

CB0940_03051

BCOM:

BAUCODRAFT_69749

TML:	GSTUM_00009427001

SPO:	SPBC800.03(clr3)

SOM:	SOMG_02175(clr3)

CNE:

CNC00780

CNB:

CNBC6490

CNG:	CNAG_01563

CGI:	CGB_C1310C

CDEU:

CNBG_3873

TMS:	TREMEDRAFT_34982

TASA:

A1Q1_00926

CCAC:

CcaHIS019_0507360(HDA1)

PCO:	PHACADRAFT_196818

SHS:	STEHIDRAFT_87305

HIR:	HETIRDRAFT_324562

PSQ:	PUNSTDRAFT_62947

FME:	FOMMEDRAFT_18146

GTR:	GLOTRDRAFT_74145

RSX:	RhiXN_06793

LBC:	LACBIDRAFT_316459(HDA16207)

CCI:	CC1G_14135

ABV:	AGABI2DRAFT118070(AGABI2DRAFT_118070)

PCUB:

JR316_0006039

MRR:	Moror_6321

E1B28_000535 E1B28_005491

SCM:	SCHCO_02691268(SCHCODRAFT_02691268)

CPUT:

CONPUDRAFT_53193

UMA:	UMAG_02102

PFP:	PFL1_03625

SGRA:

EX895_004958

MGL:

MGL_0270

MSYM:

MSY001_2743

PGR:	PGTG_15512

PTRC:

PtA15_8A138

PSTR:

Pst134EA_015368

MLR:	MELLADRAFT_90044

BEQ:	BEWA_052010

BBIG:

BBBOND_0301850

TET:	TTHERM_01014700

PTM:	GSPATT00017296001 GSPATT00019411001

PTI:	PHATRDRAFT_35869 PHATRDRAFT_45906

TPS:	THAPSDRAFT_15819

NGR:	NAEGRDRAFT_53477 NAEGRDRAFT_76158

» show all

Reference

PMID:17846173

Authors

Olzmann JA, Li L, Chudaev MV, Chen J, Perez FA, Palmiter RD, Chin LS

Title

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.

Journal

J Cell Biol 178:1025-38 (2007)
DOI:10.1083/jcb.200611128

Sequence

[hsa:10013]

Reference

PMID:10220385

Authors

Grozinger CM, Hassig CA, Schreiber SL

Title

Three proteins define a class of human histone deacetylases related to yeast Hda1p.

Journal

Proc Natl Acad Sci U S A 96:4868-73 (1999)
DOI:10.1073/pnas.96.9.4868

Sequence

[hsa:10013]

LinkDB

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