KEGG ORTHOLOGY: K10683

ORTHOLOGY: K10683

Entry

K10683                      KO

Symbol

BARD1

Name

BRCA1-associated RING domain protein 1

Pathway

map03440

Homologous recombination

Disease

H00031

Breast cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K10683  BARD1; BRCA1-associated RING domain protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K10683  BARD1; BRCA1-associated RING domain protein 1
   04121 Ubiquitin system
    K10683  BARD1; BRCA1-associated RING domain protein 1
   03036 Chromosome and associated proteins
    K10683  BARD1; BRCA1-associated RING domain protein 1
   03400 DNA repair and recombination proteins
    K10683  BARD1; BRCA1-associated RING domain protein 1
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA processing factors
   3' end processing
    Negative regulators of mRNA 3' end processing
     K10683  BARD1; BRCA1-associated RING domain protein 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   BRCC complex
    K10683  BARD1; BRCA1-associated RING domain protein 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K10683  BARD1; BRCA1-associated RING domain protein 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     K10683  BARD1; BRCA1-associated RING domain protein 1

Genes

HSA:	580(BARD1)

PTR:	470638(BARD1)

PPS:	100970977(BARD1)

GGO:	101135495(BARD1)

PON:	100447274(BARD1)

NLE:	100600973(BARD1)

HMH:	116810342(BARD1)

MCC:	694301(BARD1)

MCF:	101926157(BARD1)

MTHB:

126932028

MNI:	105481158(BARD1)

CSAB:

103217790(BARD1)

CATY:

105580151(BARD1)

PANU:

101002976(BARD1)

TGE:	112636066(BARD1)

MLEU:

105530367(BARD1)

RRO:	104669236(BARD1)

RBB:	108517972(BARD1)

TFN:	117094569(BARD1)

PTEH:

111548131(BARD1)

CANG:

105504760(BARD1)

CJC:	100405252(BARD1)

SBQ:	101047338(BARD1)

CIMI:

108308926(BARD1)

CSYR:

103250616(BARD1)

MMUR:

105867039(BARD1)

LCAT:

123643507(BARD1)

PCOQ:

105816137(BARD1)

MMU:	12021(Bard1)

MCAL:

110297033(Bard1)

MPAH:

110322177(Bard1)

RNO:	64557(Bard1)

MCOC:

116088542(Bard1)

ANU:	117706030(Bard1)

MUN:	110560534(Bard1)

CGE:	100750589(Bard1)

MAUA:

101829247(Bard1)

PROB:

127226401(Bard1)

PLEU:

114693607(Bard1)

MORG:

121433534(Bard1)

MFOT:

126508838

AAMP:

119821250(Bard1)

NGI:	103727802(Bard1)

HGL:	101722439(Bard1)

CPOC:

100731860(Bard1)

CCAN:

109674918(Bard1)

DORD:

105986476(Bard1)

DSP:	122107572(Bard1)

PLOP:

125349911(Bard1)

NCAR:

124981244

MMMA:

107138394(Bard1)

OCU:

100340914

OPI:	101533858(BARD1)

TUP:	102471796(BARD1)

GVR:	103607907(BARD1)

CFA:	102156002 610190(BARD1)

CLUD:

112656344(BARD1) 112657850

VVP:	112922456(BARD1)

VLG:	121480562(BARD1)

NPO:	129522973(BARD1)

AML:	100471907(BARD1)

UMR:	103662899(BARD1)

UAH:	113250496(BARD1)

UAR:	123798275(BARD1)

ELK:

111141165

LLV:

125095879

MPUF:

101670782(BARD1)

MNP:	132013518(BARD1)

MLK:	131827489(BARD1)

NVS:	122902275(BARD1)

ORO:	101363524(BARD1)

EJU:	114216019(BARD1)

ZCA:	113920995(BARD1)

MLX:	118012076(BARD1)

NSU:	110592015(BARD1)

LWW:	102731101(BARD1)

FCA:	101080728(BARD1)

PYU:	121031025(BARD1)

PCOO:

112866876(BARD1)

PBG:	122481733(BARD1)

PVIV:

125173088(BARD1)

LRUF:

124516100

PTG:	102969374(BARD1)

PPAD:

109265111(BARD1)

PUC:

125911226

AJU:

106977056

HHV:	120232465(BARD1)

BTA:	530961(BARD1)

BOM:	102279141(BARD1)

BIU:	109570424(BARD1)

BBUB:

102399416(BARD1)

BBIS:

105003736(BARD1)

CHX:	102173794(BARD1)

OAS:	101108373(BARD1)

BTAX:

128043553(BARD1)

ODA:	120854522(BARD1) 120862287 120879253

CCAD:

122426526(BARD1)

MBEZ:

129538265(BARD1)

SSC:	100511662(BARD1)

CFR:	102517877(BARD1)

CBAI:

105072934(BARD1)

CDK:	105099625(BARD1)

VPC:	102529589(BARD1)

BACU:

103007209(BARD1)

BMUS:

118897689(BARD1)

LVE:	103085060(BARD1)

OOR:	101277136(BARD1)

DLE:	111171801(BARD1)

PCAD:

102978596(BARD1)

PSIU:

116757141(BARD1)

NASI:

112411858(BARD1)

ECB:	100053962(BARD1)

EPZ:	103562503(BARD1)

EAI:	106832718(BARD1)

MYB:	102247141(BARD1)

MYD:	102765107(BARD1)

MMYO:

118661756(BARD1)

MLF:	102417021(BARD1)

PKL:	118709613(BARD1)

EFUS:

103289338(BARD1)

MNA:	107524810(BARD1)

DRO:	112307966(BARD1)

SHON:

118984283(BARD1)

AJM:	119062564(BARD1)

PDIC:

114494290(BARD1)

PHAS:

123829205(BARD1)

MMF:	118625738(BARD1)

PPAM:

129080658(BARD1)

HAI:	109376801(BARD1)

RFQ:	117025468(BARD1)

PALE:

102893717(BARD1)

PGIG:

120587615(BARD1)

PVP:	105291089(BARD1)

RAY:	107513399(BARD1)

MJV:	108396016(BARD1)

TOD:	119255190(BARD1)

SARA:

101549244(BARD1)

SETR:

126001107(BARD1)

LAV:	100655896(BARD1)

TMU:

101360405

ETF:	101654702(BARD1)

DNM:	101431738(BARD1)

MDO:	100014337(BARD1)

GAS:	123240124(BARD1)

SHR:	100929064(BARD1)

AFZ:

127553145

PCW:	110219473(BARD1)

OAA:	100090768(BARD1)

GGA:	424010(BARD1)

PCOC:

116236061(BARD1)

MGP:	100538376(BARD1)

CJO:	107316478(BARD1)

TPAI:

128076849(BARD1)

LMUT:

125697040(BARD1)

NMEL:

110400211(BARD1)

APLA:

101800768(BARD1)

ACYG:

106034572(BARD1)

CATA:

118243095(BARD1)

AFUL:

116490764(BARD1)

TGU:	100229796(BARD1)

LSR:	110474093(BARD1)

SCAN:

103814754(BARD1)

PMOA:

120511555(BARD1)

OTC:	121339733(BARD1)

PRUF:

121349605(BARD1)

GFR:	102040004(BARD1)

FAB:	101808348(BARD1)

OMA:	130255786(BARD1)

PHI:	102113140(BARD1)

PMAJ:

107207528(BARD1)

CCAE:

111931696(BARD1)

CCW:	104694585(BARD1)

CBRC:

103624344(BARD1)

ETL:	114060663(BARD1)

ZAB:	102065343(BARD1)

ZLE:	135450596(BARD1)

ACHL:

103804614(BARD1)

SVG:	106856545(BARD1)

MMEA:

130588884(BARD1)

HRT:	120754901(BARD1)

FPG:	101910960(BARD1)

FCH:	102046319(BARD1)

CLV:	102091012(BARD1)

EGZ:	104124163(BARD1)

NNI:	104010125(BARD1)

PCRI:

104029236(BARD1)

PLET:

104621644(BARD1)

EHS:	104506317(BARD1)

ACUN:

113482449(BARD1)

TALA:

104358681(BARD1)

PADL:

103921665(BARD1)

AFOR:

103903853(BARD1)

ACHC:

115343278(BARD1)

HALD:

104314492

HLE:	104841532(BARD1)

AGEN:

126042952

GCL:

127018451

CCRI:

104168736(BARD1)

CSTI:

104560619

CMAC:

104484508(BARD1)

MUI:

BREG:

FGA:

GSTE:

LDI:	104349350(BARD1)

MNB:	103769326(BARD1)

OHA:	104327805(BARD1)

NNT:	104402121(BARD1)

SHAB:

115608066

DPUB:

104300553(BARD1)

PGUU:

104458099

ACAR:

104527125

CPEA:

104388134(BARD1)

AVIT:

104279708(BARD1)

CVF:	104288741(BARD1)

RTD:	128913075(BARD1)

CUCA:

104067402(BARD1)

TEO:

104377857

BRHI:

104497611

AAM:	106492327(BARD1)

AROW:

112976572(BARD1)

NPD:	112956001(BARD1)

TGT:	104572180(BARD1)

DNE:	112995617(BARD1)

SCAM:

104153034(BARD1)

ASN:	102385658(BARD1)

AMJ:	102570525(BARD1)

CPOO:

109323016(BARD1)

GGN:	109301973(BARD1)

PSS:	102462924(BARD1)

CMY:	102939754(BARD1)

CCAY:

125644657(BARD1)

DCC:	119863673(BARD1)

CPIC:

101933488(BARD1)

TST:	117885178(BARD1)

CABI:

116839412(BARD1)

MRV:	120375029(BARD1)

ACS:	100563125(bard1)

ASAO:

132778427(BARD1)

PVT:	110081899(BARD1)

SUND:

121918956(BARD1)

PBI:

103065778

PMUR:

107296717(BARD1)

CTIG:

120313410

TSR:

106552234

PGUT:

117675141(BARD1)

APRI:

131199844(BARD1)

PTEX:

113441017(BARD1)

NSS:	113415658(BARD1)

VKO:	123024408(BARD1)

PMUA:

114583291(BARD1)

PRAF:

128401426(BARD1)

ZVI:	118096783(BARD1)

HCG:	128341200(BARD1)

XLA:	398242(bard1.L)

XTR:	100498289(bard1)

NPR:	108797578(BARD1)

RTEM:

120943872(BARD1)

BBUF:

121008553(BARD1)

BGAR:

122944967(BARD1)

MUO:	115474804(BARD1)

GSH:	117361532(BARD1)

DRE:	100147913(bard1)

SRX:

107741928

SANH:

107660605

SGH:	107574367 107602130

CAUA:

113053806 113108371

CGIB:

127965600

PTET:

122351380(bard1)

LROH:

127170537(bard1)

OMC:	131546465(bard1)

RKG:	130072592(bard1)

MAMB:

125270589(bard1)

CIDE:

127519097

MASI:

127446762 127448491

TROS:

130555593(bard1)

TDW:	130427108(bard1)

MANU:

129452239(bard1)

IPU:

108267028

IFU:	128608484(bard1)

PHYP:

113547445(bard1)

SMEO:

124383269(bard1)

TFD:

113655910

TVC:	132850485(bard1)

TRN:	134324142(bard1)

AMEX:

103032898(bard1)

CMAO:

118805048(bard1)

EEE:	113581334(bard1)

CHAR:

105907913(bard1)

TRU:	101068357(bard1)

TFS:	130524128(bard1)

TNG:	GSTEN00030481G001

LCO:	104928915(bard1)

TBEN:

117485589(bard1)

CGOB:

115026308(bard1)

PGEO:

117466748(bard1)

GACU:

117538377(bard1)

EMAC:

134866865(bard1)

ELY:	117250180(bard1)

EFO:	125899685(bard1)

PLEP:

121949233(bard1)

SLUC:

116050093(bard1)

ECRA:

117953010(bard1)

ESP:	116697681(bard1)

PFLV:

114563856(bard1)

GAT:	120833728(bard1)

PPUG:

119228920(bard1)

AFB:	129105060(bard1)

CLUM:

117750075(bard1)

PSWI:

130209189(bard1)

MSAM:

119903973(bard1)

SCHU:

122885741(bard1)

CUD:	121523058(bard1)

ALAT:

119026320(bard1)

MZE:

101476906

ONL:	100709333(bard1)

OAU:	116312893(bard1)

OLA:	101165605(bard1)

OML:	112155524(bard1)

CSAI:

133446038(bard1)

XMA:	102231240(bard1)

XCO:	114148948(bard1)

XHE:	116723662(bard1)

PRET:

103461621(bard1)

PFOR:

103129328

PLAI:

106962473

PMEI:

106911431

GAF:	122839364(bard1)

PPRL:

129360996(bard1)

CVG:	107088042(bard1)

CTUL:

119794881(bard1)

GMU:	124870946(bard1)

NFU:	107390149(bard1)

KMR:	108240396(bard1)

ALIM:

106527451(bard1)

NWH:	119419559(bard1)

AOCE:

111572887(bard1)

MCEP:

125017451(bard1)

CSEM:

103392231(bard1)

POV:

109631428

SSEN:

122763523(bard1)

HHIP:

117755166(bard1)

HSP:	118120491(bard1)

PPLT:

128455594(bard1)

SMAU:

118282768(bard1)

LCF:	108880436(bard1)

SDU:	111218592(bard1)

SLAL:

111671524

XGL:	120801192(bard1)

HCQ:

109531265

SSCV:

125973659

SBIA:

133511983(bard1)

PEE:	133410571(bard1)

PTAO:

133486982(bard1)

BPEC:

110156193(bard1)

MALB:

109964414(bard1)

BSPL:

114846871(bard1)

SJO:	128368366(bard1)

SASA:

106582297

STRU:

115155632

OTW:	112225573(bard1)

OMY:	110501789(bard1)

OGO:	124047459(bard1)

ONE:	115129751(bard1)

OKI:	109871367(bard1)

OKE:	118386328(bard1)

SALP:

111959807(bard1)

SNH:	120063759(bard1)

CCLU:

121554993(bard1)

ELS:

105016143

SFM:	108928924(bard1)

PKI:	111834592(bard1)

AANG:

118222425(bard1)

LOC:	102686362(bard1)

PSPA:

121322656(bard1)

ARUT:

117403681(bard1)

PSEX:

120530764(bard1)

LCM:	102364283(BARD1)

CMK:	103176560(bard1)

RTP:	109911421(bard1)

CPLA:

122551437(bard1)

HOC:	132817594(bard1)

LERI:

129698892(bard1)

PMRN:

116948736(BARD1)

LRJ:	133349627(BARD1)

BBEL:

109474683

CIN:

113474739

SCLV:

120333263

SPU:	115923889 588646

LPIC:

APLC:

SKO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

CCIN:

DPA:

SOY:	115876385 115884928

CSET:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM253180

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_102038

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

TCF:

DSV:

RMP:

VDE:

VJA:	111259831 111269982

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_K04C2.4(brd-1)

CBR:	CBG_18216(Cbr-brd-1)

CRQ:	GCK72_009961

LOA:	LOAG_02741

HRO:	HELRODRAFT_181375

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

LAK:

SMM:	Smp_137090

SHX:	MS3_00007823(BARD1_1)

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

ATH:	AT1G04020(BARD1) AT4G21070(BRCA1)

ALY:	110226490 9328256

CRB:	17878955 17898472

CSAT:

104718231 104722957 104731451 104738912 104754527 104761555

EUS:	EUTSA_v10006912mg EUTSA_v10024364mg

BRP:	103834209 103843674 103858702

BNA:	106360996 106369254 106389897 111212205

BOE:	106309671 106324492 106327949

RSZ:	108818763 108819082 108821245

THJ:	104801137 104812328

CPAP:

110807674 110819765

CIT:	102622461 102626843

CIC:	CICLE_v10014038mg CICLE_v10019112mg

PVY:	116135403 116137643

MINC:

123205286 123216120 123227406

TCC:	18607067 18613088

GRA:	105766153 105785292

GHI:	107920972 107925947 107937661 107942613

GAB:	108450599 108470792

HSYR:

120130567 120134172 120149496 120152982 120153166 120165459

DZI:	111305329 111308159

EGR:

104440745

GMX:	100306420 100784883 100789372 100804958

GSJ:	114374474 114386980 114399851 114406945

PVU:	PHAVU_001G163300g PHAVU_006G167200g

VRA:	106757946 106776217

VAR:	108323219 108340973

VUN:	114187205 114187250

VUM:	124835008 124836102

CCAJ:

109791206 109804564 109816401

APRC:

113852553 113861323

MTR:	11444771 25486045

TPRA:

123891265 123898037

CAM:	101498370 101504294

PSAT:

127079908 127126007

VVO:	131635312 131638822

LJA:	Lj0g3v0294399.1(Lj0g3v0294399.1) Lj1g3v4515780.1(Lj1g3v4515780.1) Lj6g3v1946520.1(Lj6g3v1946520.1)

ADU:	107468195 107491729

AIP:	107623632 107647828

AHF:	112695171 112714349 112758756 112782637

LANG:

109329998 109333577 109345255 109357162

PCIN:

129284783 129287213

QSA:	O6P43_006866 O6P43_010474

FVE:	101306126 101306987

RCN:	112173942 112202170

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103408982 103409196 103435036 103445590 114825176

MSYL:

126585601 126585838 126622085 126624441

PXB:	103928739 103952402 103958840 103966068

ZJU:	107405888 107425804

MNT:	21389392 21398988 21402696

CSAV:

115713887

CSV:	101212120 101222995

CMO:	103484329 103489848

BHJ:	120072726 120077624

MCHA:

111015824 111023482

CMAX:

111466809 111478687 111496720

CMOS:

111433303 111433536 111463879

CPEP:

111781192 111803452 111811558

RCU:	8266494 8286057

JCU:	105634038 105644497

HBR:	110651162 110657594

MESC:

110604583 110628392 110630408

POP:	7470812 7474513

PEU:	105125619 105141262

PALZ:

118056220 118056826

JRE:	108995999 109011087

CILL:

122277755 122305375

CAVE:

132165998 132171250

QSU:	112005203 112007387 112041012

QLO:	115962168 115992642

TWL:	119990757 120013863

VVI:	100253255 100256563

VRI:	117917940 117922959

SLY:	101256694 101256776 101264126

SPEN:

107005400 107018841 107022026 107028944 107029828

SOT:	102579131 102585833 102589099

SSTN:

125842243 125870301 125874857

SDUL:

129882766 129889055 129898664

CANN:

107838819 107863815 107873646

LBB:	132605718 132610669 132611460

NTA:	107812739 107819652 107820519 107821036 107822351

NSY:	104230488 104233611 104236241

NTO:	104095287 104100008 104117807

NAU:	109214883 109229352 109240085

INI:	109161537 109165815

ITR:	116017426 116032058

SIND:

105163449 105175767

OEU:	111369754 111386948 111396953 111405785

EGT:	105948751 105951922

SSPL:

121756492 121759732 121760006 121763621

SMIL:

130985147 131014270

SHIS:

125213634

APAN:

127247670 127258986

HAN:	110896139 110903917 110903919 110936854

ECAD:

122590625 122605131 122605709

LSV:	111880851 111891930 111891932

CCAV:

112503747 112520170

DCR:	108199916 108214626 108220926 108222481

CSIN:

114289285 114297100

RVL:	131312914 131313255 131321041

AEW:	130770179 130787323 130791379

BVG:	104899222 104901168

SOE:	110787069 110791021

CQI:	110689728 110699843 110727996 110728499

ATRI:

130813696 130824131 130827554

MOF:	131154808 131168474

NNU:	104602810 104610819

MING:

122071454 122085091 122087390

TSS:	122641376 122650764 122653951

PSOM:

113284113 113285057 113288422 113296795 113298340 113303164 113316581 113356300

OSA:	107276010 4336384 4339293

DOSA:

Os04t0512400-01(Os04g0512400) Os05t0486600-01(Os05g0486600) Os05t0512000-01(Os05g0512000)

OBR:	102701266 102704508 102705916

OGL:	127771364 127772521 127774672

BDI:	100835205 100842545 100842826

ATS:	109748902 109763934 109765467 109779560

TDC:	119284286 119286446 119348726 119348946 119350604 119355882 119359074 119365023 119367428

TAES:

123040853 123046135 123048868 123054018 123060331 123062367 123092179 123094424 123139632 123182393 123184872 123189904

TUA:	125521885 125524224 125524234 125527934 125530898

LPER:

127318661 127327244 127335572 127340671 127345891

LRD:	124648743 124648744 124649943 124660119 124661986 124662286 124664595 124671586 124678714

SBI:	8056469 8064471 8067490 8077022

ZMA:	100273997 100281664 103630583

SITA:

101758628 101767419 101773588

SVS:	117848506 117850126 117863266

PVIR:

120642400 120664967 120665117 120682209 120698321

PHAI:

112883844 112885722 112901111

PDA:	103703717 103716250

EGU:	105044204 105046724 105058864

MUS:	103989451 103993160 103994536

ZOF:	121968612 122032842 122035223 122054166

DCT:	110091968 110106692 110110039

PEQ:	110021115 110027718

AOF:	109836394 109848972 109850440

MSIN:

131243392 131245804

NCOL:

116254089 116257328 116265468

ATR:	18427207 18447293

SMO:	SELMODRAFT_414577

OLU:	OSTLU_24500

OTA:	OT_ostta05g00310

MBR:	MONBRDRAFT_25825

SRE:	PTSG_06892

» show all

Reference

PMID:15905410

Authors

Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL

Title

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

Journal

Genes Dev 19:1227-37 (2005)
DOI:10.1101/gad.1309505

Sequence

[hsa:580]

Reference

PMID:10477523

Authors

Kleiman FE, Manley JL

Title

Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

Journal

Science 285:1576-9 (1999)
DOI:10.1126/science.285.5433.1576

Sequence

[hsa:580]

LinkDB

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